Results 41 to 50 of about 1,957,077 (351)

Inhibition of Sirt2 Alleviates Fibroblasts Activation and Pulmonary Fibrosis via Smad2/3 Pathway

Frontiers in Pharmacology, 2021
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with unknown cause and limited treatment options. Its mechanism needs to be further explored. Sirtuin2 (Sirt2), a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, has been proved to be ...
Hui Gong, Chenyi Zheng, Xing Lyu, Lini Dong, Shengyu Tan, Xiangyu Zhang   +5 more
doaj   +1 more source

Substrate stiffness modulates cardiac fibroblast activation, senescence and proinflammatory secretory phenotype - Supplemental Data

, 2023
Supplemental data for manuscript: Substrate stiffness modulates cardiac fibroblast activation, senescence and proinflammatory secretory ...
Timothy McKinsey (12010199)
core   +1 more source

Isolation of Fibroblast-Activation Protein-Specific Cancer-Associated Fibroblasts [PDF]

BioMed Research International, 2017
The current study is to develop a gentle and efficient method for purification of fibroblast-activation protein positive (FAP+) cancer-associated fibroblasts (CAFs) from tumor tissues. Fresh tissues were isolated from BALB/c-Nude mice bearing human liver cancer cell line (HepG2), fully minced and separated into three parts, and digested with trypsin ...
Yingying Huang, Sufang Zhou, Yong Huang, Duo Zheng, Qiqi Mao, Jian He, Yiwei Wang, Dabing Xue, Xiaoling Lu, Nuo Yang, Yongxiang Zhao   +10 more
openaire   +2 more sources

MD Trajectories for "In-Silico analysis of Fibroblast Activation Protein (FAP) ligand selectivity" Manuscript

, 2023
<p>Supplementary Information for the "In-Silico analysis of Fibroblast Activation Protein (FAP) ligand selectivity" Manuscript</p ...
Ciancetta, Antonella
core   +1 more source

Paracrine signaling of ferroptotic airway epithelium in crystalline silica-induced pulmonary fibrosis augments local fibroblast activation through glycolysis reprogramming

Ecotoxicology and Environmental Safety
Chronic exposure to crystalline silica (CS) contributes to pulmonary fibrosis. Airway epithelium dysfunction and fibroblast activation have both been recognized as pivotal players, alongside disturbances in ferroptosis and glycolysis reprogramming ...
Qianmin Li, Yi Ling, Yu Ma, Tao Zhang, Youjing Yang, Shasha Tao   +5 more
doaj   +1 more source

TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation

, 2020
The supplemental data for manuscript titled 'TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation'
Aravamudhan, Aja, Haak, Andrew J., Jones, Dakota L., Choi, Kyoung M., Caporarello, Nunzia, Tschumperlin, Daniel J., Tan, Qi, Meridew,Jeffrey A., Ligresti, Giovanni   +8 more
core   +1 more source

Correction: Hypoxia Preconditioned Mesenchymal Stem Cells Prevent Cardiac Fibroblast Activation and Collagen Production via Leptin. [PDF]

, 2015
Correction: Hypoxia Preconditioned Mesenchymal Stem Cells Prevent Cardiac Fibroblast Activation and Collagen Production via ...
Zhi Jiang, Ling Zhang, Rongrong Wu (613911), Panpan Chen, Hong Yu (6528), Yinchuan Xu, Xinyang Hu, Zhaocai Zhang, Han Chen (228557), Yinchuan Xu (495165), Wei Zhu, Xinyang Hu (495166), Han Chen, Huiqiang Chen, Zhi Jiang (269212), Hong Yu, Rongrong Wu, Jian'an Wang, Panpan Chen (307628), Wei Zhu (23646), Zhaocai Zhang (495169), Ling Zhang (18071), Huiqiang Chen (495170), Jian'an Wang (613912)   +23 more
core   +1 more source

A transcriptional switch governs fibroblast activation in heart disease

, 2021
In diseased organs, stress-activated signalling cascades alter chromatin, thereby triggering maladaptive cell state transitions. Fibroblast activation is a common stress response in tissues that worsens lung, liver, kidney and heart disease, yet its
Duan, Qiming, Sadagopan, Nandhini, Joshua G. Travers, Przytycki, Pawel F, Ye, Lin, Silva, Ana Catarina, Lin Ye, Alexanian, Michael, Jain, Rajan, Rosenfeld, Michael G, Clara Youngna Lee, Li, Li, Pawel F. Przytycki, Ricardo Linares-Saldana, Gonzalez-Teran, Barbara, Timothy A. McKinsey, Sanjeev S. Ranade, Ana Catarina Silva, Pelonero, Angelo, Deepak Srivastava, Gaia Andreoletti, Nandhini Sadagopan, Angelo Pelonero, Casey A. Gifford, Lee, Clara Youngna, Padmanabhan, Arun, Travers, Joshua G, Arun Padmanabhan, Katherine S. Pollard, Linares-Saldana, Ricardo, Saptarsi M. Haldar, Michael G. Rosenfeld, Ranade, Sanjeev S, Andreoletti, Gaia, Gifford, Casey A, Srivastava, Deepak, Qiming Duan, Li Li, Rudi Micheletti, Barbara Gonzalez-Teran, Yu Huang, Huang, Yu, Haldar, Saptarsi M, Micheletti, Rudi, McKinsey, Timothy A, Felix, Franco, Franco Felix, Michael Alexanian, Rajan Jain, Pollard, Katherine S   +49 more
core   +1 more source

Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1

Redox Biology
Cardiac fibrosis remains an unresolved clinical issue in patients with heart diseases. CircRNAs have emerged as potential targets for treatment of heart diseases.
Yan Chen, Zhewei Zhang, Yue Cheng, Xiaofeng Chen, Junteng Zhou, Zisong Wei, Han Yao, Shuwen Zhang, Qihang Kong, Hao Tang, Wenchao Wu, Zhichao Zhou, Xiaoqiang Tang, Xiaojing Liu   +13 more
doaj   +1 more source

Nε-Carboxymethyl-Lysine Modification of Extracellular Matrix Proteins Augments Fibroblast Activation

, 2023
The extracellular matrix (ECM) is a dynamic complex protein network that provides structural integrity and plays an active role in shaping fibroblast behavior both in health and disease.
Patrick Hester, Geereddy Bhanuprakash Reddy, Adithi Yepuri, Harshavardhana H. Ediga, Satish K. Madala   +4 more
core   +1 more source