Results 51 to 60 of about 1,957,077 (351)

Yoda1 Inhibits TGFβ-Induced Cardiac Fibroblast Activation via a BRD4-Dependent Pathway

Cells
Fibrosis represents a pivotal pathological process in numerous diseases, characterized by excessive deposition of extracellular matrix (ECM) that disrupts normal tissue architecture and function.
Perwez Alam, Sara M. Stiens, Hunter J. Bowles, Hieu Bui, Douglas K. Bowles   +4 more
doaj   +1 more source

S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis

Frontiers in Immunology, 2018
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease, characterized by damage of lung epithelial cells, excessive deposition of extracellular matrix in the lung interstitium, and enhanced activation and proliferation of ...
Wei Zhang, Wei Zhang, Wei Zhang, Shinji Ohno, Shinji Ohno, Shinji Ohno, Beatrix Steer, Beatrix Steer, Beatrix Steer, Stephan Klee, Stephan Klee, Stephan Klee, Claudia A. Staab-Weijnitz, Claudia A. Staab-Weijnitz, Darcy Wagner, Darcy Wagner, Darcy Wagner, Mareike Lehmann, Mareike Lehmann, Mareike Lehmann, Tobias Stoeger, Melanie Königshoff, Melanie Königshoff, Melanie Königshoff, Melanie Königshoff, Heiko Adler, Heiko Adler, Heiko Adler   +27 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cardiac fibroblast deletion of PTBP1 modulates the profibrotic response by alternative splicing

Nature Communications
Dynamic cardiac fibroblast phenotypes drive pathological remodeling and fibrosis, yet post-transcriptional mechanisms controlling fibroblast activation remain poorly defined.
Shea N. Ricketts, Gregory M. Farber, Sunil K. Verma, Yanhan Dong, Yifang Xie, Paige R. Takasugi, Shufen Chen, Luping Du, Haofei Wang, Wei Hui, Celine Keles, Sergey Tsoy, Grace Fuller, Michael Wang, Gabrielle M. Gentile, Jimena Giudice, Muge N. Kuyumcu-Martinez, Jiandong Liu, Li Qian   +18 more
doaj   +1 more source

PI3K/AKT-associated fibroblast activation by native

Journal of Genetic Engineering and Biotechnology
Spidroins, the main structural protein constituents of spider silk, show excellent mechanical strength, durability and biocompatibility; therefore, they are potentially useful biomaterials for medical uses.
Sri Raagavee Sivakumar, Kamarajan Rajagopalan, Rajendran Venkatesh, Jackson Durairaj Selvan Christyraj, P. Susheela, Shobana Sampath, Douglas Law, Gholamreza Abdi   +7 more
doaj   +1 more source

Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardiac fibrosis via regulating fatty acid metabolism

Redox Biology, 2023
Cardiac fibrosis is characterized by the excessive deposition of extracellular matrix in the myocardium with cardiac fibroblast activation, leading to chronic cardiac remodeling and dysfunction.
Geer Tian, Junteng Zhou, Yue Quan, Qihang Kong, Junli Li, Yanguo Xin, Wenchao Wu, Xiaoqiang Tang, Xiaojing Liu   +8 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α. [PDF]

, 2020
Cytokine-primed neutrophils can undergo a nonapoptotic type of cell death using components of the necroptotic pathway, including receptor-interacting protein kinase-3 (RIPK3), mixed lineage kinase-like (MLKL) and NADPH oxidase. In this report, we provide
Perozzo, Remo, Hosseini, Aref, Simon, Hans-Uwe, Kuchen, Stefan, Gessier, Francois, Amirshahrokhi, Keyvan, Loetscher, Pius, Yousefi, Shida, Lötscher, Pius, Stojkov, Darko, Wang, Xiaoliang, Kuchen S, Yousefi S, Simon HU, Gessier F, Amirshahrokhi K, Perozzo R, Lötscher P, Wang X, Hosseini A, Stojkov D   +20 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source