Results 71 to 80 of about 1,957,077 (351)

Calcium ions released from alginate hydrogel promote wound healing by enhancing fibroblast activity

Frontiers in Bioengineering and Biotechnology
Hydrogels are widely used as wound dressings owing to their biocompatibility, high water content, and ability to mimic extracellular matrix functions. Alginate (ALG) is a natural polysaccharide that forms ionically crosslinked hydrogels in the presence ...
Lei Zhang, Lei Zhang, Lei Zhang, Ying Luo, Shubo Liu, Shubo Liu, Huiting Deng, Yingtang Gao, Yingtang Gao, Yingtang Gao   +9 more
doaj   +1 more source

Advancements in theranostic applications: exploring the role of fibroblast activation protein inhibition tracers in enhancing thyroid health assessment

EJNMMI Research, 2023
Background The diagnostic accuracy of [18F]-fluorodeoxyglucose ([18F]-FDG) positron emission tomography imaging in accurately identifying thyroid lesions is limited, primarily due to the physiological uptake of normal head and neck tissues and ...
Yuhua Wang, Ye Liu, Huixia Geng, Wanchun Zhang   +3 more
doaj   +1 more source

Analysis of Drosophila Fibroblast Growth Factor Functional Domains [PDF]

, 2011
The exciting Fibroblast Growth Factor (FGF) field lies at the crossroads of cell signaling, development, evolution, trafficking, physiology and human disease.
Tulin, Sarah Lynn
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Emerging Epigenetic Therapies for the Treatment of Cardiac Fibrosis

Biomedicines
Fibrosis is a pathological process characterized by excessive extracellular matrix (ECM) deposition, leading to tissue stiffening and organ dysfunction.
Nerea Garitano, Laura Pilar Aguado-Alvaro, Beatriz Pelacho   +2 more
doaj   +1 more source

Fibroblast activation protein activated antifibrotic peptide delivery attenuates fibrosis in mouse models of liver fibrosis

Nature Communications, 2022
Activated hepatic stellate cells contribute towards the pathogenesis of liver fibrosis, and overexpress fibroblast activation protein. Here the authors report a targeted peptide-delivery system in which fibroblast activation protein liberates the ...
Jaiwoo Lee, Junho Byun, Gayong Shim, Yu-Kyoung Oh   +3 more
doaj   +1 more source

The Effects of Berberine and Nitroxl (HNO) on the Glucose Uptake in L929 Fibroblast Cells [PDF]

, 2012
Berberine, which has a long history of use in Chinese medicine, has recently been shown to have efficacy in the treatment of diabetes. While the hypoglycemic effect of berberine has been clearly documented in animal and cell line models, such as 3T3-L1 ...
Chenge, Jude Terver-Jeremiah
core  

The role of promoter hypermethylation in fibroblast activation and fibrogenesis

, 2013
The aberrant methylation of CpG island promoters of selected genes is the prominent epigenetic mechanism by which gene transcription can be effectively silenced.
Zeisberg, Elisabeth M., Elisabeth M Zeisberg, Michael Zeisberg, Zeisberg, Michael   +3 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Krüppel-Like Factor 4 Is a Regulator of Proinflammatory Signaling in Fibroblast-Like Synoviocytes through Increased IL-6 Expression

Mediators of Inflammation, 2016
Human fibroblast-like synoviocytes play a vital role in joint synovial inflammation in rheumatoid arthritis (RA). Proinflammatory cytokines induce fibroblast-like synoviocyte activation and dysfunction.
Xinjing Luo, Jie Chen, Jianwei Ruan, Yongfeng Chen, Xuanrong Mo, Jiangwen Xie, Guoju Lv   +6 more
doaj   +1 more source