Results 81 to 90 of about 1,957,077 (351)

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Nature Communications, 2020
Fibroblast hyper-activation and proliferation is a major feature in arthritis, yet scarcely addressed for anti-arthritic therapies. Here, the authors show that activation of the MC1 receptor induces fibroblast senescence associated with a reparative ...
Trinidad Montero-Melendez, Ai Nagano, Claude Chelala, Andrew Filer, Christopher D. Buckley, Mauro Perretti   +5 more
doaj   +1 more source

Inducible Activation of RelB in Fibroblasts

Journal of Biological Chemistry, 1996
RelB, a member of NF-kappaB/Rel family of transcriptional regulators, is an immediate-early gene product that mediates constitutive lymphoid-specific kappaB-directed gene expression. Data presented here show that RelB also functions as a mitogen-inducible DNA binding activity in fibroblasts.
openaire   +2 more sources

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Fibroblast activation and inflammation in frozen shoulder [PDF]

PLOS ONE, 2019
Frozen shoulder is a common, fibro-proliferative disease characterised by the insidious onset of pain and progressively restricted range of shoulder movement. Despite the prevalence of this disease, there is limited understanding of the molecular mechanisms underpinning the pathogenesis of this debilitating disease.
Akbar, Moeed, McLean, Michael, Garcia-Melchor, Emma, Crowe, Lindsay A.N., McMillan, Paul, Fazzi, Umberto G., Martin, David, Arthur, Angus, Reilly, James H., McInnes, Iain B., Millar, Neal L.   +10 more
openaire   +3 more sources

Fibroblast Activation Protein Inhibitor-PET Imaging in Colorectal Cancer

, 2023
Fibroblast activation protein inhibitor (FAPI)-PET imaging holds great promise for improving the clinical management of colorectal cancer. High fibroblast activation protein expression is particularly observed in lymph node metastases, in the aggressive ...
Lam, Marnix, Kranenburg, Onno, Strating, Esther, van de Loo, Anne, Elias, Sjoerd, Researchgr. Nucleaire Geneeskunde, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Cancer, Epi Kanker Team C, Lab Translational Oncology, Cancer   +10 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis

EMBO Molecular Medicine, 2020
Fibroblast activation including proliferation, survival, and ECM production is central to initiation and maintenance of fibrotic lesions in idiopathic pulmonary fibrosis (IPF). However, druggable molecules that target fibroblast activation remain limited.
Rajesh K Kasam, Sudhir Ghandikota, Divyalakshmi Soundararajan, Geereddy B Reddy, Steven K Huang, Anil G Jegga, Satish K Madala   +6 more
doaj   +1 more source

Mechanisms of Fibroblast Activation in the Remodeling Myocardium [PDF]

Current Pathobiology Reports, 2017
Activated fibroblasts are critically implicated in repair and remodeling of the injured heart. This manuscript discusses recent progress in the cell biology of fibroblasts in the infarcted and remodeling myocardium, highlighting advances in understanding the origin, function and mechanisms of activation of these cells.Following myocardial injury ...
Arti V, Shinde, Nikolaos G, Frangogiannis   +1 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Tissue Reaction to Monofilament Grafts of Different Weights Used for Abdominal Wall Reinforcement

Biomedicines
Background/Objectives: Hernia and pelvic organ prolapse often involve defects necessitating reinforcement with synthetic materials. Polypropylene meshes of varying weights are commonly used in abdominal wall repair; however, their impact on tissue ...
Milan Potić, Ivan Ignjatović, Dragoslav Bašić, Ljubomir Dinić, Bojan Vučković, Nebojša Jovanović, Slavica Stojnev   +6 more
doaj   +1 more source