Results 31 to 40 of about 1,957,077 (351)

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
O\u27Brien, Pamela, O'Brien, Pamela, O'Connor, Brendan, O\u27Connor, Brendan   +3 more
core   +2 more sources

Regulation of Cardiac Fibroblast GLS1 Expression by Scleraxis

Cells, 2022
Fibrosis is an energy-intensive process requiring the activation of fibroblasts to myofibroblasts, resulting in the increased synthesis of extracellular matrix proteins.
Sikta Chattopadhyaya, Raghu S. Nagalingam, D. Allison Ledingham, Teri L. Moffatt, Danah S. Al-Hattab, Pavit Narhan, Matthew T. Stecy, Kimberley A. O’Hara, Michael P. Czubryt   +8 more
doaj   +1 more source

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Guimond, S, Bouloux, PM, Turnbull, Jeremy, Turnbull, J, Hu, Youli, Kim, SH, Kim, Soo-Hyun, Schofield, Jonathan, Winyard, P, Winyard, Paul, Vannelli, GB, Bouloux, Pierre-Marc, Gonzalez-Martinez, D, Hu, YL, Schofield, J, Vannelli, Gabriella Barbara, González-Martínez, David, Guimond, Scott   +17 more
core   +1 more source

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder [PDF]

, 2011
The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a ‘driver’ of UCC, we targeted the expression of mutated
Taketo, M.M., Leung, H.Y., Hing Y. Leung, Wu, X.-R., Iwata, T., Mona Foth, Morris, C.-A., Owen J. Sansom, Lukram Babloo Singh, Tomoko Iwata, Imran Ahmad, Carol-Ann Morris, Makoto Mark Taketo, Singh, L.B., Foth, M., Sansom, O.J., Xue-Ru Wu, Ahmad, I.   +17 more
core   +1 more source

Cardiomyocyte intercellular signalling increases oxidative stress and reprograms the global‐ and phospho‐proteome of cardiac fibroblasts

Journal of Extracellular Biology, 2023
Pathological reprogramming of cardiomyocyte and fibroblast proteome landscapes drive the initiation and progression of cardiac fibrosis. Although the secretome of dysfunctional cardiomyocytes is emerging as an important driver of pathological fibroblast ...
Bethany Claridge, Alin Rai, Jarmon G. Lees, Haoyun Fang, Shiang Y. Lim, David W. Greening   +5 more
doaj   +1 more source

Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin

Frontiers in Immunology, 2023
Inflammation is known to play a critical role in all stages of tumorigenesis; however, less is known about how it predisposes the tissue microenvironment preceding tumor formation.
Morgan Anderson-Crannage, Morgan Anderson-Crannage, Alex M. Ascensión, Olga Ibanez-Solé, Hongwen Zhu, Edo Schaefer, Darcy Ottomanelli, Bruno Hochberg, Jian Pan, Wen Luo, Meijuan Tian, Yaya Chu, Mitchell S. Cairo, Mitchell S. Cairo, Mitchell S. Cairo, Mitchell S. Cairo, Ander Izeta, Ander Izeta, Yanling Liao   +18 more
doaj   +1 more source

Functional dissection of the "Drosophila melanogaster" fibroblast growth factor signalling pathway in branching morphogenesis of the developing tracheal system [PDF]

, 2004
Fibroblast Growth Factor (FGF) signalling is involved in numerous developmental processes ranging from cell determination to mitogenesis, and cell survival to cell migration.
Dossenbach, Caroline
core   +1 more source

Electrospun Scaffold Micro-Architecture Induces an Activated Transcriptional Phenotype within Tendon Fibroblasts

Frontiers in Bioengineering and Biotechnology, 2022
Biomaterial augmentation of surgically repaired rotator cuff tendon tears aims to improve the high failure rates (∼40%) of traditional repairs. Biomaterials that can alter cellular phenotypes through the provision of microscale topographical cues are now
Mathew J. Baldwin, Jolet Y. Mimpen, Adam P. Cribbs, Edward Stace, Martin Philpott, Stephanie G. Dakin, Andrew J. Carr, Sarah JB. Snelling   +7 more
doaj   +1 more source

Shear Stress Induces the Release of an Endothelial Elastase: Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release [PDF]

, 2011
Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes.
Hennig, Theres, Christina Mogensen, Gloe, Torsten, Kirsch, Julian, Julian Kirsch, Torsten Gloe, Ulrich Pohl, Pohl, Ulrich, Theres Hennig, Mogensen, Christina   +9 more
core   +1 more source

The effect of tranilast on fibroblast activation protein α (FAP-α) expression in normal and keloid fibroblasts in vitro [PDF]

, 2017
Introduction . Tranilast (N-(3’,4’-demethoxycinnamoyl)-anthranilic acid) is an anti-allergic drug. Its mechanism of action is based on the inhibition of antigen-induced release of chemical mediators from mast cells and basophils.
Paweł P. Antończak, Magdalena Jurzak, Agnieszka Garncarczyk, Magdalena Hartman-Petrycka, Katarzyna Adamczyk   +4 more
core   +1 more source