Results 21 to 30 of about 1,957,077 (351)

Proteomic Insights into Cardiac Fibrosis: From Pathophysiological Mechanisms to Therapeutic Opportunities

Molecules, 2022
Cardiac fibrosis is a common pathophysiologic process in nearly all forms of heart disease which refers to excessive deposition of extracellular matrix proteins by cardiac fibroblasts.
Ruiqiang Qi, E. Lin, Juan Song, Yan Wang, Ling Lin   +4 more
doaj   +1 more source

Activation and suppression of fibroblast function [PDF]

Eye, 1994
The fibroblast is the central player in the wound repair and scarring processes that occur in the anterior segment of the eye. Glaucoma filtration surgery is the ultimate example of the importance of the wound healing process, as this process is the major determinant of the success of this procedure. We highlight the role of the fibroblast, and discuss
P T, Khaw, N L, Occleston, G, Schultz, I, Grierson, M B, Sherwood, G, Larkin   +5 more
openaire   +2 more sources

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation [PDF]

, 2009
Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania, Dominguez, V., Tania Maffucci, Gianluca Sala, Raimondi C, Dominguez V, Dominguez Veronica, Abu-Hayyeh S, Zachary I, Falasca Marco, Raimondi Claudio, Sala, Gianluca, Claudio Raimondi, Maffucci Tania, Abu-Hayyeh, Shadi, Falasca, Marco, Zachary, Ian, Raimondi, C, Sala, G, Abu-Hayyeh, S, Veronica Dominguez, Zachary, I., Falasca M, Maffucci T, Maffucci, T, Ian Zachary, Dominguez, Veronica, Sala G, Falasca, M, Sala Gianluca, Shadi Abu-Hayyeh, Marco Falasca, Maffucci, T., Sala, G., Abu-Hayyeh Shadi, Raimondi, C., Dominguez, V, Zachary, I, Raimondi, Claudio, Zachary Ian, Abu-Hayyeh, S.   +40 more
core   +1 more source

Reduced Fibroblast Activation on Electrospun Polycaprolactone Scaffolds [PDF]

, 2023
In vivo, quiescent fibroblasts reside in three-dimensional connective tissues and are activated in response to tissue injury before proliferating rapidly and becoming migratory and contractile myofibroblasts.
Woodley, J.P., Joe P. Woodley, Lambert, D.W., Daniel W. Lambert, Ilida Ortega Asencio, Asencio, I.O., Lambert, Daniel W., Asencio, Ilida Ortega, Woodley, Joe P.   +8 more
core   +1 more source

Matrix Gla Protein is a novel regulator of TGFβ-dependent fibroblast activation and kidney fibrosis. [PDF]

Mol Biomed
Kidney fibrosis is the pathologic hallmark of chronic kidney disease (CKD) and is driven by fibroblast-to-myofibroblast transformation (FMT), excessive extracellular matrix accumulation, and persistent activation of transforming growth factor-β (TGFβ ...
Barrera-Chimal J, López-Ramírez J, Henley N, Gao P, Ma Y, Desjardins-Lecavalier N, Costantino S, Royal V, Agten SM, Borrás T, Pichette V, Yuen DA, Schurgers LJ, Gerarduzzi C.   +13 more
europepmc   +2 more sources

Molecular networks in FGF signaling: Flotillin-1 and Cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2 [PDF]

, 2012
Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Traub Stephanie, Tomasovic, Ana, Stephanie Traub, Ana Tomasovic, Ana Tomasovic (189773), Ritva Tikkanen (189783), Tikkanen Ritva, Tikkanen, Ritva, Traub, Stephanie, Tomasovic Ana, Ritva Tikkanen, Stephanie Traub (189777)   +11 more
core   +2 more sources

Effects of bone morphogenetic protein 4 on TGF-β1-induced cell proliferation, apoptosis, activation and differentiation in mouse lung fibroblasts via ERK/p38 MAPK signaling pathway [PDF]

PeerJ, 2022
Fibroblasts, in particular myofibroblasts, are the critical effector cells in idiopathic pulmonary fibrosis (IPF), a deadly lung disease characterized by abnormal lung remodeling and the formation of “fibroblastic foci”.
Zhou Cai, Hua Guo, Jing Qian, Wei Liu, Yuanyuan Li, Liang Yuan, You Zhou, Ran Lin, Xiaohui Xie, Qiong Yang, Guoying Wu, Qiongqiong Li, Li Zhao, Fei Liu, Jian Wang, Wenju Lu   +15 more
doaj   +2 more sources

An Active Electrical Response in Fibroblasts [PDF]

The Journal of General Physiology, 1972
L cells have a resting potential of about -16 mv (internal negative) at 37°C in Dulbecco's modified Eagle's medium containing 10% fetal calf serum and a potassium concentration of 5.4 mM. Membrane resistivity is about 20,000 Ωcm2 when the surface filopodia described by others are taken into account. Mechanical and electrical stimuli can evoke an active
P G, Nelson, J, Peacock, J, Minna
openaire   +2 more sources

Fibroblast Activation Protein Expression in Sarcomas [PDF]

Sarcoma, 2023
Objectives. Fibroblast activation protein alpha (FAP) is highly expressed by cancer-associated fibroblasts in multiple epithelial cancers. The aim of this study was to characterize FAP expression in sarcomas to explore its potential utility as a diagnostic and therapeutic target and prognostic biomarker in sarcomas. Methods.
Jacquelyn N. Crane, Danielle S. Graham, Christine E. Mona, Scott D. Nelson, Alireza Samiei, David W. Dawson, Sarah M. Dry, Marwan G. Masri, Joseph G. Crompton, Matthias R. Benz, Johannes Czernin, Fritz C. Eilber, Thomas G. Graeber, Jeremie Calais, Noah C. Federman   +14 more
openaire   +3 more sources

The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking [PDF]

, 2009
Neural cell adhesion molecule (NCAM) associates with fibroblast growth factor (FGF) receptor-1 (FGFR1). However, the biological significance of this interaction remains largely elusive.
Vladimir Berezin, Gerhard Christofori, Christofori, Gerhard, Francavilla, Chiara; id_orcid, Paola Cattaneo, Cattaneo, Paola, Ugo Cavallaro, Cavallaro, Ugo, de Marco, Ario, Francavilla, Chiara, Ami, Diletta, Berezin, Vladimir, Ario de Marco, Chiara Francavilla, Bock, Elisabeth, Elisabeth Bock, Diletta Ami, Ami Diletta, Christofori Gerhard, De Marco A., Cattaneo Paola, Berezin Vladimir, Cavallaro Ugo, Ami D., De Marco Ario, Christofori G., Bock E., Francavilla C., Cattaneo P., Cavallaro U., Bock Elisabeth, Francavilla Chiara, Berezin V.   +32 more
core   +1 more source