Results 11 to 20 of about 5,296,642 (245)

Radiosynthesis and First Preclinical Evaluation of the Novel 11C-Labeled FAP Inhibitor 11C-FAPI: A Comparative Study of 11C-FAPIs and (68Ga) Ga-DOTA-FAPI-04 in a High–FAP-Expression Mouse Model

Frontiers in Chemistry, 2022
Purpose: 68Ga-labeled fibroblast activation protein inhibitors, such as [68Ga]Ga-DOTA-FAPI-04 and [68Ga]Ga-DOTA-FAPI-46, have been successfully applied in positron emission tomography imaging of various tumor types.
Cheng Wang, Zhoumi Hu, Fan Ding, Haitao Zhao, Fuqiang Du, Chun Lv, Lianghua Li, Gang Huang, Gang Huang, Jianjun Liu   +9 more
doaj   +1 more source

TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts

Respiratory Research, 2023
Background Lung fibroblast activation is associated with airway remodeling during asthma progression. Stearoyl-CoA desaturase 1 (SCD1) plays an important role in the response of fibroblasts to growth factors.
Zili Zhou, Shixiu Liang, Zicong Zhou, Jieyi Liu, Jinming Zhang, Xiaojing Meng, Fei Zou, Haijin Zhao, Changhui Yu, Shaoxi Cai   +9 more
doaj   +1 more source

Computer-aided design, synthesis, and biological evaluation of [4.3.0] bicyclic prolyl oligopeptidase and fibroblast activation protein-α dual inhibitors [PDF]

, 2021
We have previously described several different chemical series of bicyclic prolyl oligopeptidase (POP) inhibitors as probes for neurodegenerative diseases that demonstrated nanomolar activity in vitro and submicromolar activity in cellulo.
Nicolas, Moitessier, Maud, Pousse, Anthony, Mittermaier, Damien, Hedou, Jessica, Plescia, Caroline, Dufresne, Anne, Labarre   +6 more
core   +2 more sources

Cardiomyocyte intercellular signalling increases oxidative stress and reprograms the global‐ and phospho‐proteome of cardiac fibroblasts

Journal of Extracellular Biology, 2023
Pathological reprogramming of cardiomyocyte and fibroblast proteome landscapes drive the initiation and progression of cardiac fibrosis. Although the secretome of dysfunctional cardiomyocytes is emerging as an important driver of pathological fibroblast ...
Bethany Claridge, Alin Rai, Jarmon G. Lees, Haoyun Fang, Shiang Y. Lim, David W. Greening   +5 more
doaj   +1 more source

FAPI-04 PET/CT Using [18F]AlF Labeling Strategy: Automatic Synthesis, Quality Control, and In Vivo Assessment in Patient

Frontiers in Oncology, 2021
68Ga labeled FAPI is the current standard for FAPI-PET, but its batch activity is limited. [18F]AlF-NOTA-FAPI-04 is a promising alternative combining the advantages of a chelator-based radiolabeling method with the unique properties of fluorine-18.
Xiao Jiang, Xiao Jiang, Xiaoxiong Wang, Taipeng Shen, Yutang Yao, Meihua Chen, Zeng Li, Xiuli Li, Jiaqi Shen, Ying Kou, Shirong Chen, Xing Zhou, Zhifu Luo, Zhuzhong Cheng   +13 more
doaj   +1 more source

Fibroblast heterogeneity in non-small cell lung cancer and optical imaging targeting fibroblast activation protein [PDF]

, 2023
Cancer associated fibroblasts (CAFs) are one of the predominant cell types of non-small cell lung cancer (NSCLC) tumour stroma. This thesis will investigate fibroblast heterogeneity in NSCLC; defining their phenotype by expression of CAF markers ...
Mathieson, Layla
core   +1 more source

68Ga-FAPI-04 PET/MR is helpful in differential diagnosis of pancreatitis from pancreatic malignancy compared to 18F-FDG PET/CT: a case report

European Journal of Hybrid Imaging, 2021
Introduction 68Ga-fibroblast activation protein-specific enzyme inhibitor 04 (FAPI-04) is a radiolabelled molecular agent targeting the inhibitor of fibroblast activation protein (FAP), which is often present in tumor stroma and inflammatory tissue with ...
Yi Shou, Qiaoyi Xue, Jianmin Yuan, Jun Zhao   +3 more
doaj   +1 more source

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
O\u27Brien, Pamela, O'Brien, Pamela, O'Connor, Brendan, O\u27Connor, Brendan   +3 more
core   +2 more sources

Molecular networks in FGF signaling: Flotillin-1 and Cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2 [PDF]

, 2012
Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Traub Stephanie, Tomasovic, Ana, Stephanie Traub, Ana Tomasovic, Ana Tomasovic (189773), Ritva Tikkanen (189783), Tikkanen Ritva, Tikkanen, Ritva, Traub, Stephanie, Tomasovic Ana, Ritva Tikkanen, Stephanie Traub (189777)   +11 more
core   +2 more sources

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation [PDF]

, 2009
Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania, Dominguez, V., Tania Maffucci, Gianluca Sala, Raimondi C, Dominguez V, Dominguez Veronica, Abu-Hayyeh S, Zachary I, Falasca Marco, Raimondi Claudio, Sala, Gianluca, Claudio Raimondi, Maffucci Tania, Abu-Hayyeh, Shadi, Falasca, Marco, Zachary, Ian, Raimondi, C, Sala, G, Abu-Hayyeh, S, Veronica Dominguez, Zachary, I., Falasca M, Maffucci T, Maffucci, T, Ian Zachary, Dominguez, Veronica, Sala G, Falasca, M, Sala Gianluca, Shadi Abu-Hayyeh, Marco Falasca, Maffucci, T., Sala, G., Abu-Hayyeh Shadi, Raimondi, C., Dominguez, V, Zachary, I, Raimondi, Claudio, Zachary Ian, Abu-Hayyeh, S.   +40 more
core   +1 more source