Results 1 to 10 of about 5,298,587 (157)

Fibroblast Activation Protein Inhibitor (FAPI)-Based Theranostics [PDF]

Pharmaceuticals
Fibroblast activation protein (FAP) is a serine protease selectively expressed in cancer-associated fibroblasts (CAFs), fibrotic tissues, and areas of active tissue remodeling, making it an attractive target for diagnostic imaging across a spectrum of ...
William Serumula, Venesen Pillay, Bawinile Hadebe, Mariza Vorster   +3 more
doaj   +5 more sources

Fibroblast Activation Protein Inhibitor (FAPI) PET: A Scoping Review of Emerging Oncologic and Fibroinflammatory Applications [PDF]

Diagnostics
This scoping review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines.
Emmanouil Panagiotidis, Filippos Koinis, Jules Zhang-Yin, George Angelidis, Varvara Valotassiou, Ioannis Tsougos, Athanasios Kotsakis, Panagiotis Georgoulias   +7 more
doaj   +4 more sources

The Superiority of Fibroblast Activation Protein Inhibitor (FAPI) PET/CT Versus FDG PET/CT in the Diagnosis of Various Malignancies. [PDF]

Cancers (Basel), 2023
Cancer represents a major cause of death worldwide and is characterized by the uncontrolled proliferation of abnormal cells that escape immune regulation.
Dong Y, Zhou H, Alhaskawi A, Wang Z, Lai J, Yao C, Liu Z, Hasan Abdullah Ezzi S, Goutham Kota V, Hasan Abdulla Hasan Abdulla M, Lu H.   +10 more
europepmc   +3 more sources

Gallium-68 fibroblast activation protein inhibitor positron emission tomography in cardiovascular disease [PDF]

Frontiers in Nuclear Medicine, 2023
Gallium-68 fibroblast activation protein inhibitor [(68Ga)Ga-FAPI] is a new radiopharmaceutical positioning itself as the preferred agent in patients with malignant tumours, competing with 2-Deoxy-2-[18F]fluoro-d-glucose [2-(18F)FDG] using positron ...
Dineo Mpanya, Mike Sathekge, Mike Sathekge, Eric Klug, Eric Klug, Jenna Damelin, Stuart More, Bawinile Hadebe, Bawinile Hadebe, Mariza Vorster, Mariza Vorster, Nqoba Tsabedze   +11 more
doaj   +2 more sources

Fibroblast activation protein inhibitor (FAPI) PET for diagnostics and advanced targeted radiotherapy in head and neck cancers. [PDF]

Eur J Nucl Med Mol Imaging, 2020
PURPOSE Cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein (FAP) have been associated with the aggressive nature of head and neck cancers (HNCs).
Syed M, Flechsig P, Liermann J, Windisch P, Staudinger F, Akbaba S, Koerber SA, Freudlsperger C, Plinkert PK, Debus J, Giesel F, Haberkorn U, Adeberg S.   +12 more
europepmc   +3 more sources

Fibroblast activation protein inhibitor (FAPI) PET imaging in pulmonary fibrosis: pathophysiology, clinical utility, and emerging theranostic applications [PDF]

Respiratory Research
Pulmonary fibrosis arises from a dysregulated wound-healing response in which activated fibroblasts drive excessive extracellular matrix deposition and irreversible lung architectural distortion.
Ali Al-waqeerah, Huanyu He, Ahmed Bashah, Eslam Ghaleb, Nan Wang, Lili Gao   +5 more
doaj   +2 more sources

[68Ga]Ga-FAPI-46 PET enables non-invasive monitoring of hepatic fibrosis progression during TGF-β inhibition [PDF]

Scientific Reports
Hepatic fibrosis, a precursor to cirrhosis and hepatocellular carcinoma, affects millions worldwide but lacks effective therapies and depends on invasive liver biopsies for diagnosis, which hinder early intervention and monitoring.
Yeeun Kim, Myeongguk Jeong, Go-Eun Choi, Hyeokjin Kwon, Hyun Jin Yoon, Young-Jin Jeong, Ji Yong Park, Do-Young Kang, Sungmin Jun   +8 more
doaj   +2 more sources

Fibroblast Activation Protein Inhibitor (FAPI)-Based Theranostics-Where We Are at and Where We Are Heading: A Systematic Review. [PDF]

Int J Mol Sci, 2023
Sidrak MMA, De Feo MS, Corica F, Gorica J, Conte M, Filippi L, Schillaci O, De Vincentis G, Frantellizzi V.   +8 more
europepmc   +2 more sources

Prognostic value of cardiac fibroblast activation heterogeneity assessed by FAPI PET radiomics in hypertrophic cardiomyopathy: a proof-of-concept study [PDF]

Open Heart
Background Hypertrophic cardiomyopathy (HCM) is associated with an increased risk of sudden cardiac death (SCD), and myocardial fibrosis plays a central role in the pathophysiology process.
Li Wang, Jun Zhao, Qingxia Wu, Jie Ding, haoyu Song, Yilu Wang, Minfu Yang   +6 more
doaj   +2 more sources

Preclinical evaluation of homodimeric FAPI target modules for UniCAR-mediated targeting of FAP-expressing tumor and stromal cells [PDF]

OncoImmunology
Due to its overexpression in the tumor microenvironment of most solid malignancies, fibroblast activation protein (FAP) has emerged as an ideal target for (immuno)theranostic applications.
Hugo Boutier, Simona Mattiussi, Liliana R. Loureiro, Nicole Berndt, Antonia Stammberger, Nathalia Jones-Cifuentes, Lydia Hoffmann, Emile Verhulst, Marc Schmitz, Ingrid De Meester, Umberto M. Battisti, Claudia Arndt, Anja Feldmann, Frank Roesch, Matthias M. Herth, Michael Bachmann   +15 more
doaj   +2 more sources