Results 1 to 10 of about 4,897,809 (228)

Targeting fibroblast activation protein-α to treat renal fibrosis

Cellular & Molecular Biology Letters
Background Renal fibrosis is the common outcome of chronic renal disease. Currently, there are no effective therapies. Fibroblast activation and extracellular matrix accumulation are key processes driving renal fibrosis.
Li Gong, Xinyu Lu, Na Ma, Tao Lu, Yuhong Gong, Liwei Hao, Weikang Xu, Qianbing Zhang, Xiaolan Chen, Qinglin Mo, Jiexing Tan, Henrique de Paula Lemos, Alexander Speechley, Wenwei Tu, Jianpiao Cai, Lei Huang, Wei Zhu, Sha Wu   +17 more
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Unveiling the Tumor Microenvironment Through Fibroblast Activation Protein Targeting in Diagnostic Nuclear Medicine: A Didactic Review on Biological Rationales and Key Imaging Agents

Biology
The tumor microenvironment (TME) is a dynamic and complex medium that plays a central role in cancer progression, metastasis, and treatment resistance. Among the key elements of the TME, cancer-associated fibroblasts (CAFs) are particularly important for
Juliette Fouillet, Jade Torchio, Léa Rubira, Cyril Fersing   +3 more
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Fibroblast activation protein inhibitor (FAPI) PET imaging in pulmonary fibrosis: pathophysiology, clinical utility, and emerging theranostic applications

Respiratory Research
Pulmonary fibrosis arises from a dysregulated wound-healing response in which activated fibroblasts drive excessive extracellular matrix deposition and irreversible lung architectural distortion.
Ali Al-waqeerah, Huanyu He, Ahmed Bashah, Eslam Ghaleb, Nan Wang, Lili Gao   +5 more
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Recent clinical advances in fibroblast activation protein targeted radioligand therapy for solid tumors

Frontiers in Nuclear Medicine
Fibroblast activation protein (FAP) is a type II transmembrane serine protease predominantly expressed by cancer-associated fibroblasts (CAFs) in more than 90% of epithelial malignancies.
Xiaolong Wu, Yu Wang, Yingchun Li, Wenli Hu   +3 more
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FAP-Targeted Nanoparticle-based Imaging in Cancer: A Systematic Review [PDF]

Journal of Biomedical Physics and Engineering
Background: Fibroblast Activation Protein (FAP)-targeted nanoparticles (NPs) are designed to accumulate in cancerous stroma. These NPs hold promise for imaging applications in cancer therapy.Objective: This systematic review aimed to comprehensively ...
Samaneh Abbasi, Sara Khademi, Alireza Montazerabadi, Amirhossein Sahebkar   +3 more
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Role of Fibroblast Activation Protein Alpha in Fibroblast-like Synoviocytes of Rheumatoid Arthritis

Iranian Journal of Allergy, Asthma and Immunology, 2021
Fibroblast-like synoviocytes (FLSs) have been introduced in recent years as a key player in the pathogenesis of rheumatoid arthritis (RA), but the exact mechanisms of their transformation and intracellular pathways have not yet been determined.
Mohammad Javad Mousavi, Elham Farhadi, Mohammad Vodjgani, Jafar Karami, Mohammad Naghi Tahmasebi, Arash Sharafat Vaziri, Marzieh Asgari, Nima Rezaei, Shayan Mostafaei, Ahmadreza Jamshidi, Mahdi Mahmoudi   +10 more
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Fibroblast Activation Protein-α as a Target in the Bench-to-Bedside Diagnosis and Treatment of Tumors: A Narrative Review

Frontiers in Oncology, 2021
Fibroblast activation protein-α (FAP) is a type II integral serine protease that is specifically expressed by activated fibroblasts. Cancer-associated fibroblasts (CAFs) in the tumor stroma have an abundant and stable expression of FAP, which plays an ...
Lei Xin, Jinfang Gao, Ziliang Zheng, Yiyou Chen, Shuxin Lv, Zhikai Zhao, Chunhai Yu, Xiaotang Yang, Ruiping Zhang   +8 more
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circNOX4 activates an inflammatory fibroblast niche to promote tumor growth and metastasis in NSCLC via FAP/IL-6 axis

Molecular Cancer
Background Cancer-associated fibroblasts (CAFs) orchestrate a supportive niche that fuels cancer metastatic development in non-small cell lung cancer (NSCLC).
Yan Zhao, Yunlong Jia, Jiali Wang, Xiaolin Chen, Jingya Han, Shuman Zhen, Shuxian Yin, Wei Lv, Fan Yu, Jiaqi Wang, Fan Xu, Xinming Zhao, Lihua Liu   +12 more
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Expression of fibroblast-activation protein in keloid tissue and its clinical significance

Pifu-xingbing zhenliaoxue zazhi, 2020
Objective: To investigate the expression of fibroblast-activation protein(FAP) in keloid tissue and its role in the development of keloid. Methods: Immunochemical staining was used to evaluate the expression of FAP in 30 cases of keloid tissue (case ...
Yu-xiong ZOU, Ming-chun CHEN, Li-da XU
doaj   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science
Background: Thoracic aortic dissection (TAD) is a lethal vascular emergency lacking targeted therapies. Fibroblast activation protein (FAP), a protease implicated in tissue remodeling, exhibits unknown roles in TAD pathogenesis.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
doaj   +1 more source