Results 31 to 40 of about 4,897,809 (228)

Fibroblast Activation Protein (FAP)-Mediated Cleavage of Type III Collagen Reveals Serum Biomarker Potential in Non-Small Cell Lung Cancer and Spondyloarthritis. [PDF]

Biomedicines
Pedersen RS, Thorlacius-Ussing J, Raimondo MG, Langholm LL, Schett G, Ramming A, Karsdal M, Willumsen N.   +7 more
europepmc   +2 more sources

Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP). [PDF]

Sci Rep, 2017
AbstractFibroblast Activation Protein (FAP) is a membrane-bound serine protease whose expression is often elevated in activated fibroblasts associated with tissue remodeling in various common diseases such as cancer, arthritis and fibrosis. Like the closely related dipeptidyl peptidase DPPIV, the extracellular domain of FAP can be released into ...
Bainbridge TW, Dunshee DR, Kljavin NM, Skelton NJ, Sonoda J, Ernst JA.   +5 more
europepmc   +4 more sources

Enhancing fibroblast activation protein (FAP)-targeted radionuclide therapy with albumin binding, and beyond. [PDF]

Eur J Nucl Med Mol Imaging, 2022
Younis MH, Malih S, Lan X, Rasaee MJ, Cai W.   +4 more
europepmc   +3 more sources

Oncogenesis, Microenvironment Modulation and Clinical Potentiality of FAP in Glioblastoma: Lessons Learned from Other Solid Tumors

Cells, 2021
Currently, glioblastoma (GBM) is the most common malignant tumor of the central nervous system in adults. Fibroblast activation protein (FAP) is a member of the dipeptidyl peptidase family, which has catalytic activity and is engaged in protein ...
Yixin Shi, Ziren Kong, Penghao Liu, Guozhu Hou, Jiaming Wu, Wenbin Ma, Xin Cheng, Yu Wang   +7 more
doaj   +1 more source

Fibroblast Activation Protein (FAP): A Crucial Modulator of the Microenvironment in Metastatic Melanoma Case. [PDF]

Indian J Nucl Med
A 55-year-old male with advanced malignant melanoma received surgery, radiotherapy, and chemotherapy. Despite these treatments, [18F]FDG PET/CT showed significant disease progression. Targeted imaging with gallium-68 radiotracers for CXCR4, SSTR 2 , and FAP identified biomarkers for ...
Divband G, Hedayati R, Amini H, Hassanzadeh L.   +3 more
europepmc   +3 more sources

Computer-aided design, synthesis, and biological evaluation of [4.3.0] bicyclic prolyl oligopeptidase and fibroblast activation protein-α dual inhibitors [PDF]

, 2021
We have previously described several different chemical series of bicyclic prolyl oligopeptidase (POP) inhibitors as probes for neurodegenerative diseases that demonstrated nanomolar activity in vitro and submicromolar activity in cellulo.
Nicolas, Moitessier, Maud, Pousse, Anthony, Mittermaier, Damien, Hedou, Jessica, Plescia, Caroline, Dufresne, Anne, Labarre   +6 more
core   +2 more sources

Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and FibrosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Fibroblast activation protein (FAP) is expressed on activated fibroblast. Its role in fibrosis and desmoplasia is controversial, and data on pharmacological FAP inhibition are lacking.
Ai-Ting Yang, Yong-Ook Kim, Xu-Zhen Yan, Hiroyuki Abe, Misbah Aslam, Kyoung-Sook Park, Xin-Yan Zhao, Ji-Dong Jia, Thomas Klein, Hong You, Detlef Schuppan   +10 more
doaj   +1 more source

Spatial profiling of cancer-associated fibroblasts of sporadic early onset colon cancer microenvironment

npj Precision Oncology, 2023
The incidence of sporadic early-onset colon cancer (EOCC) has increased worldwide. The molecular mechanisms in the tumor and the tumor microenvironment (TME) in EOCC are not fully understood.
Satoru Furuhashi, Matias A. Bustos, Shodai Mizuno, Suyeon Ryu, Yalda Naeini, Anton J. Bilchik, Dave S. B. Hoon   +6 more
doaj   +1 more source

Fibroblast Activation Protein-α (FAP) Identifies Stromal Invasion in Colorectal Neoplasia

American Journal of Surgical Pathology, 2023
The increasing detection of colorectal adenomas and early adenocarcinomas (ADCs) in the context of nationwide screening programs has led to a significant increase in the incidence of inconclusive diagnoses in which histopathologic analysis of endoscopic biopsies does not allow pathologists to provide a reliable diagnosis of stromal invasion.
Alexandre Tarín-Nieto, Jon D. Solano-Iturri, Inés Arrieta-Aguirre, Asier Valdivia, María C. Etxezarraga, Alberto Loizate, José I. López, Gorka Larrinaga   +7 more
openaire   +2 more sources

MD Trajectories for "In-Silico analysis of Fibroblast Activation Protein (FAP) ligand selectivity" Manuscript

, 2023
<p>Supplementary Information for the "In-Silico analysis of Fibroblast Activation Protein (FAP) ligand selectivity" Manuscript</p ...
Ciancetta, Antonella
core   +1 more source