Results 21 to 30 of about 4,897,809 (228)

Genetic ablation of fibroblast activation protein alpha attenuates left ventricular dilation after myocardial infarction.

PLoS ONE, 2021
IntroductionRegulating excessive activation of fibroblasts may be a promising target to optimize extracellular matrix deposition and myocardial stiffness.
Daniel B Hoffmann, Daniela Fraccarollo, Paolo Galuppo, Stefan Frantz, Johann Bauersachs, Jochen Tillmanns   +5 more
doaj   +2 more sources

Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice [PDF]

Journal of Biological Chemistry, 2016
Idiopathic pulmonary fibrosis is a disease characterized by progressive, unrelenting lung scarring, with death from respiratory failure within 2–4 years unless lung transplantation is performed. New effective therapies are clearly needed. Fibroblast activation protein (FAP) is a cell surface-associated serine protease up-regulated in the lungs of ...
Fan, Ming-Hui, Zhu, Qiang, Li, Hui-Hua, Ra, Hyun-Jeong, Majumdar, Sonali, Gulick, Dexter L., Jerome, Jacob A., Madsen, Daniel H., Christofidou-Solomidou, Melpo, Speicher, David W., Bachovchin, William W., Feghali-Bostwick, Carol, Puré, Ellen   +12 more
openaire   +4 more sources

Fibroblast Activation Protein (FAP) targeting homodimeric FAP inhibitor radiotheranostics: a step to improve tumor uptake and retention time. [PDF]

Am J Nucl Med Mol Imaging, 2021
Several radiopharmaceuticals targeting fibroblast activation protein (FAP) based on the highly potent FAP inhibitor UAMC1110 are currently under investigation. Pre-clinical as well as clinical research exhibited the potential of these imaging agents.
Moon ES, Ballal S, Yadav MP, Bal C, Van Rymenant Y, Stephan S, Bracke A, Van der Veken P, De Meester I, Roesch F.   +9 more
europepmc   +5 more sources

Rational Design and Pharmacomodulation of Protein-Binding Theranostic Radioligands for Targeting the Fibroblast Activation Protein

, 2022
The fibroblast activation protein (FAP), overexpressed on cancer-associated fibroblasts (CAFs), has become a valuable target for tumor diagnosis and therapy. However, most FAP-based radioligands show insufficient tumor uptake and retention. In this study,
Lingxin Meng (1647838), Zhide Guo (1424674), Zuoquan Zhao (1728325), Tingting Wang (123983), Liang Zhao (94728), Pu Yuan (12791495), Xianzhong Zhang (1424671), Qin Lin (406035), Haojun Chen (3727810), Rongqiang Zhuang (1923625), Xiaoyuan Chen (322516), Jianyang Fang (11301298)   +11 more
core   +8 more sources

Understanding the Cancer-Associated Fibroblast (CAF) and Its Biomarker Fibroblast Activation Protein (FAP), and Aspects in Human Liver Cancer

Frontiers in Bioscience-Landmark
Tumours contain many fibroblasts, endothelial cells, and leukocytes that are emerging as therapeutic targets complementary to targeting genetically unstable cancer cells.
Yiqun Amy Qu, JiaLi C. Huang, Ziqi V. Wang, Angela L. Ferguson, Jasmine Minh Hang Nguyen, MingChang Zhang, Katharine A. Osborne, Badwi B. Boumelhem, Geoffrey W. McCaughan, Ken Liu, Mark D. Gorrell   +10 more
doaj   +3 more sources

Clinical results of fibroblast activation protein (FAP) specific PET for non-malignant indications: systematic review. [PDF]

EJNMMI Res, 2021
Windisch P, Zwahlen DR, Giesel FL, Scholz E, Lugenbiel P, Debus J, Haberkorn U, Adeberg S.   +7 more
europepmc   +2 more sources

Specific inhibition of fibroblast activation protein (FAP)-alpha prevents tumor progression in vitro

Advances in Medical Sciences, 2015
Solid tumors modulate their environment to keep non-malignant stromal cells in a tumor-promoting state. The main cells in the stroma of epithelial derived tumors are cancer associated fibroblasts (CAF) that are critical to tumorigenesis and angiogenesis.
Teichgräber, Volker, Monasterio, Carmen, Chaitanya, Krishna, Boger, Regina, Gordon, Katrin, Dieterle, Thomas, Jäger, Dirk, Bauer, Stefan   +7 more
openaire   +5 more sources

Could Fibroblast Activation Protein (FAP)-Specific Radioligands Be Considered as Pan-Tumor Agents? [PDF]

Contrast Media Mol Imaging, 2022
Background. Cancer‐associated fibroblasts (CAFs) can strongly modulate the response to therapy of malignant tumor cells, facilitating their continuous proliferation and invading behaviors. In this context, several efforts were made in identifying the fibroblast activation protein (FAP) as a CAF recognizer and in designing FAP‐specific PET radiotracers (
Roustaei H, Kiamanesh Z, Askari E, Sadeghi R, Aryana K, Treglia G.   +5 more
europepmc   +4 more sources

Fibroblast heterogeneity in non-small cell lung cancer and optical imaging targeting fibroblast activation protein [PDF]

, 2023
Cancer associated fibroblasts (CAFs) are one of the predominant cell types of non-small cell lung cancer (NSCLC) tumour stroma. This thesis will investigate fibroblast heterogeneity in NSCLC; defining their phenotype by expression of CAF markers ...
Mathieson, Layla
core   +1 more source

RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α. [PDF]

, 2020
Cytokine-primed neutrophils can undergo a nonapoptotic type of cell death using components of the necroptotic pathway, including receptor-interacting protein kinase-3 (RIPK3), mixed lineage kinase-like (MLKL) and NADPH oxidase. In this report, we provide
Perozzo, Remo, Hosseini, Aref, Simon, Hans-Uwe, Kuchen, Stefan, Gessier, Francois, Amirshahrokhi, Keyvan, Loetscher, Pius, Yousefi, Shida, Lötscher, Pius, Stojkov, Darko, Wang, Xiaoliang, Kuchen S, Yousefi S, Simon HU, Gessier F, Amirshahrokhi K, Perozzo R, Lötscher P, Wang X, Hosseini A, Stojkov D   +20 more
core   +2 more sources