Results 41 to 50 of about 4,897,809 (228)

TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells

Journal of Translational Medicine, 2023
Background Bladder cancer is one of the most common malignant tumors of the urinary system and is associated with a poor prognosis once invasion and distant metastases occur.
Qinrong Ping, Chunhui Wang, Xin Cheng, Yiming Zhong, Ruping Yan, Meng Yang, Yunqiang Shi, Xiangmeng Li, Xiao Li, Wenwen Huang, Liqiong Wang, Xiaofang Bi, Libing Hu, Yang Yang, Yingbao Wang, Rui Gong, Jun Tan, Rui Li, Hui Li, Jian Li, Wenju Wang, Ruhong Li   +21 more
doaj   +1 more source

FAP promotes metastasis and chemoresistance via regulating YAP1 and macrophages in mucinous colorectal adenocarcinoma

iScience, 2023
Summary: Mucinous colorectal adenocarcinoma (MC) is less likely to respond to chemotherapy and is associated with poorer prognosis compared with non-MC (NMC).
Dengbo Ji, Jinying Jia, Xinxin Cui, Zhaowei Li, Aiwen Wu   +4 more
doaj   +1 more source

An efficacious opportunity for diagnosis and treatment of cancers: Radiolabeled fibroblast activation protein (FAP) inhibitors. [PDF]

Bioimpacts
Despite the revolutionized diagnostic effect of fluorine-18 -fludeoxyglucose ([18F]-FDG) as a positron emission tomography (PET) radiotracer in oncological divisions, lack of specificity and sensitivity in discovery of some tumor subtypes was inevitable.
Vahidfar N, Aghanejad A.
europepmc   +4 more sources

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
O\u27Brien, Pamela, O'Brien, Pamela, O'Connor, Brendan, O\u27Connor, Brendan   +3 more
core   +2 more sources

Therapeutic Applications of Fibroblast Activation Protein (FAP)-Binding Radiopharmaceuticals: Review of Opportunities and Challenges. [PDF]

Cancers (Basel)
Fibroblast activation protein (FAP)-binding radiopharmaceuticals have emerged as promising candidates for both diagnostic and therapeutic applications in oncology due to their selective targeting of cancer-associated fibroblasts (CAFs). This review evaluates the current literature on the therapeutic use of FAP-targeted radiopharmaceuticals in human ...
Maes J, Pôlet B, Kleynhans J, Van Herpe F, Goffin K, Dekervel J, Nafteux P, Topal B, Cleeren F, Deroose CM.   +9 more
europepmc   +5 more sources

SNMMI Procedure Standard/EANM Practice Guideline for Fibroblast Activation Protein (FAP) PET. [PDF]

J Nucl Med
sponsorship: NCI NIH HHS|P30 CA015083, NCI NIH HHS|R01 CA256969, NCI NIH HHS|R01 ...
Hope TA, Calais J, Goenka AH, Haberkorn U, Konijnenberg M, McConathy J, Oprea-Lager DE, Trimnal L, Zan E, Herrmann K, Deroose CM.   +10 more
europepmc   +7 more sources

Cord Blood-Derived Fibroblast Activation Protein-Targeted Chimeric Antigen Receptor Natural Killer Cells Persist in Vivo. [PDF]

Cancer Sci
We generated cord blood‐derived FAP‐targeted CAR NK cells and evaluated their activity against cancer‐associated fibroblasts. These cells showed antigen‐specific cytotoxicity in vitro and robust persistence in a pleural dissemination model, although in vivo anti‐CAF efficacy was limited, supporting further development of stromal‐targeted cellular ...
Hiroshima T, Kimura T, Maekawa M, Noguchi M, Matsui T, Ikeda S, Suga M, Nagata H, Kimura K, Fukui E, Kanou T, Ose N, Morii E, Shintani Y, Hosen N.   +14 more
europepmc   +2 more sources

The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactions

Journal of Advanced Research, 2020
Cancer-associated fibroblasts (CAF) are a cellular compartment of the tumor microenvironment (TME) with critical roles in tumor development. Fibroblast activation protein-α (FAP) is one of the proteins expressed by CAF and its immunohistochemical ...
Peio Errarte, Gorka Larrinaga, José I. López   +2 more
doaj   +1 more source

Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-κB pathway to promote metastasis

Cell Death and Disease, 2021
Fibroblast activation protein alpha (FAP) is a marker of cancer-associated fibroblast, which is also expressed in cancer epithelial cells. However, the role of FAP in colorectal cancer (CRC) cells remains to be elucidated.
Ziming Yuan, Hanqing Hu, Yihao Zhu, Weiyuan Zhang, Qingxiao Fang, Tianyu Qiao, Tianyi Ma, Meng Wang, Rui Huang, Qingchao Tang, Feng Gao, Chaoxia Zou, Xu Gao, Guiyu Wang, Xishan Wang   +14 more
doaj   +1 more source

Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model [PDF]

BMB Reports, 2013
Fibroblast activation protein (FAP) is a specific serine proteaseexpressed in tumor stroma proven to be a stimulatory factor inthe progression of some cancers.
Fan Cai, Zhiyong Li, Chunting Wang, Shuang Xian, Guangchao Xu, Feng Peng, Yuquan Wei, You Lu   +7 more
doaj   +1 more source