Results 41 to 50 of about 5,298,587 (157)

sj-pdf-1-ajs-10.1177_03635465231208843 – Supplemental material for Fibroblast Activation Protein–Targeted PET/CT with Al18F-NODA-FAPI-04 for In Vivo Imaging of Tendon Healing in Rat Achilles Tendon Injury Models

, 2023
Supplemental material, sj-pdf-1-ajs-10.1177_03635465231208843 for Fibroblast Activation Protein–Targeted PET/CT with Al18F-NODA-FAPI-04 for In Vivo Imaging of Tendon Healing in Rat Achilles Tendon Injury Models by Zhenfeng Liu, Haiying Zhou, Pengfei Li ...
Zhenfeng Liu (431113), Xinhui Su (1341387), Yanzhao Dong (13948111), Tian Tu (5899157), Hui Lu (12370), Sohaib Hasan Abdullah Ezzi (14261924), Pengfei Li (290581), Vishnu Goutham Kota (5216144), Mengjie Dong (6396161), Ahmad Alhaskawi (14261918), Yuqiao Huang (11421561), Zewei Wang (2120281), Haiying Zhou (1315533), Mohamed Hasan Abdulla Hasan Abdulla (17414288)   +13 more
core   +1 more source

Cardiovascular positron emission tomography imaging of fibroblast activation: A review of the current literature [PDF]

Fibrosis is one of the key healing responses to injury, especially within the heart where it helps to maintain structural integrity following acute insults such as myocardial infarction.
Gimelli, Alessia, Barton, Anna, Joshi, Shruti, Newby, David E., Craig, Neil, Slart, Riemer H J A, Dweck, Marc R, Anagnostopoulos, Constantinos, Newby, David, Lubberink, Mark, Lubberink, Mark,, Hyafil, Fabien, Gheysens, Olivier, Saraste, Antti, Gaemperli, Oliver, Buechel, Ronny R, Buechel, Ronny R., Dweck, Marc R., Glaudemans, Andor W.J.M., Glaudemans, Andor W J M, Glaudemans, Andor W J M; id_orcid, Newby, David E, Loganath, Krithika, Bucerius, Jan, Erba, Paola Anna, Buechel, Ronny, Habib, Gilbert, Slart, Riemer H.J.A., Dweck, Marc   +28 more
core   +2 more sources

The Glioma Model micro-PET Imaging and Biodistribution of 68Ga Labeled Fibroblast Activation Protein Inhibitor

Journal of Isotopes, 2022
To investigate the biodistribution and micro-PET imaging of 68Ga labeled fibroblast activation protein inhibitor (68Ga-FAPI-04) in normal mice and glioma nude mice, 68Ga-FAPI-04 was synthesized using DOTA-modified fibroblast activation protein inhibitor ...
XIANG Yili;ZHONG Xuan;FU Jingjing;WU Wenyu;SHAO Guoqiang;WANG Feng;ZHANG Jun
doaj  

Click‐to‐Release Reactivity of Quaternary Anilinium Tetrazines Enables Cascade Assembly of Multifunctional Biomolecular Scaffolds

Angewandte Chemie International Edition, EarlyView.
Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Usefulness of FAPα assessment in bronchoalveolar lavage as a marker of fibrogenesis: results of a preclinical study and first report in patients with idiopathic pulmonary fibrosis.

, 2023
Fibroblast activation protein-α (FAPα) is a marker of activated fibroblasts that can be selectively targeted by an inhibitor (FAPI) and visualised by PET/CT imaging. We evaluated whether the measurement of FAPα in bronchoalveolar lavage fluids (BALF) and
Cardozo, Alessandra Kupper, Allard, Justine, Garabet, Ani, Van Heymbeek, Christophe, Pingitore, Julien, Doumont, Gilles, Lacroix, Simon, Passon, Nicolas, Goldman, Serge, Salmon, Isabelle, De Maeseneire, Coraline, Collin, Amandine, Huaux, François, Van Simaeys, Gaëtan, Bondue, Benjamin, Decaestecker, Christine, Lavis, Philomène, Cardozo, Alessandra K   +17 more
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using (68)Ga-FAPI-04

, 2021
Our previous study has demonstrated the feasibility of noninvasive imaging of fibroblast activation protein (FAP)-expression after myocardial infarction (MI) in MI-territory in a rat model with (68)Ga-FAPI-04-PET.
Notohamiprodjo, Susan, Laugwitz, Karl-Ludwig, Varasteh, Zohreh, Makowski, Marcus, Schwaiger, Markus, Weber, Wolfgang, Ibrahim, Tareq, Makowski, Marcus R., Kupatt, Christian, Nekolla, Stephan G., Weber, Wolfgang A., Robu, Stephanie, Villagran Asiares, Alberto, Susan Notohamiprodjo, Marcus R. Makowski, Zohreh Varasteh, Stephan G. Nekolla, Wolfgang A. Weber, Stephanie Robu, Karl-Ludwig Laugwitz, Markus Schwaiger, Christian Kupatt, Tareq Ibrahim, Alberto Villagran Asiares   +23 more
core   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT Findings of Abdominal Leiomyosarcoma

, 2021
A 56-year-old woman presented with abdominal pain and vomiting. Her abdominal CT revealed an retroperitoneal mass in the left upper quadrant of the abdomen.
Gundes, Ebubekir, Guzel, Yunus, Can, Canan, Sogutcu, Nilgun, Gundogan, Cihan   +4 more
core   +1 more source