Results 61 to 70 of about 5,298,587 (157)

Fibroblast Activation Protein Expression Differs Between Inflamed and Fibrostenotic Inflammatory Bowel Disease

JCC Plus, Volume 1, Issue 5, September 2026.
This study demonstrates that fibroblast activation protein expression is elevated in inflamed and fibrostenotic inflammatory bowel disease, with highest levels in fibrostenotic Crohn's disease. Cellular fibroblast activation protein predominates in inflamed tissues and localises to α‐SMA−PDPN−CD90+ stromal cells. ABSTRACT Background Intestinal fibrosis
Dalia A. Lartey, Bram W. van Os, Bo Jun Ke, Kelly van Wijnbergen, Gert de Hertogh, Luuk J. A. C. Hawinkels, Gianluca Matteoli, Jie Su, Christianne J. Buskens, Jarmilla D. W. van der Bilt, Geert R. A. M. D'Haens, Joep Grootjans, Manon E. Wildenberg, Marieke C. Barnhoorn, Mark Löwenberg   +14 more
wiley   +1 more source

Prognostic impact of discordant lesions on [18F]FDG and [68Ga]Ga-FAPI-04 PET/CT compared to histological FAP expression in neuroendocrine neoplasms

Frontiers in Nuclear Medicine
ObjectiveOn dual-tracer positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) and fibroblast activation protein inhibitor ([⁶⁸Ga]Ga-FAPI-04), discordant lesions (FDG+/FAPI-) in aggressive neuroendocrine
Tim Jedamzik, Aleksander Kosmala, Stefan Kircher, Marieke Heinrich, Wiebke Schlötelburg, Andreas K. Buck, Alexander Meining, Alexander Meining, Rudolf A. Werner, Rudolf A. Werner, Rudolf A. Werner, Alexander Weich, Alexander Weich, Kerstin Michalski   +13 more
doaj   +1 more source

Application of 68Ga‐ and 177Lu‐Labeled FAP Inhibitor in Evaluation and Treatment of Cardiac Fibrosis After Myocardial Infarction

MedComm
68Ga and 177Lu‐labeled fibroblast activation protein inhibitor (FAPI) have been introduced for the diagnosis and treatment of multiple malignant and non‐malignant diseases.
Yiheng Zhao, Xiangyu Su, Boyang Xiang, Shuchen Zhang, Xiang Zhou   +4 more
doaj   +1 more source

Imaging the Tumor Microenvironment Beyond Anatomy: Functional, Immune, Stromal, and Metabolic Signatures for Precision Oncology

iRADIOLOGY, Volume 4, Issue 4, Page 287-304, August 2026.
This article highlights the importance of imaging the tumor microenvironment (TME) beyond conventional anatomy‐based approaches to enable more precise oncology. It focuses on capturing key biological dimensions of tumors—vascular function and hypoxia, immune response, stromal remodeling, and metabolic activity—using advanced imaging techniques.
Karthikeyan Elumalai, Gayathri Krishnakumar   +1 more
wiley   +1 more source

A case with68ga-fapi positive and18f-fdg negative breast cancer 68 ga-fapi pozitif,18f-fdg negatif meme kanseri olgusu

, 2021
© 2021 by Turkish Society of Nuclear Medicine Molecular Imaging and Radionuclide Therapy published by Galenos Yayınevi.A female patient diagnosed of infiltrative breast carcinoma using tru-cut biopsy underwent18flourine-fluorodeoxyglucose (18F-FDG ...
Etem, Hülya, Gündoğan, Cihan, Kömek, Halil, Can, Canan   +3 more
core   +1 more source

Recent implications of FAPI PET in cardiac diseases

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Fibroblast activation protein (FAP), highly expressed in activated fibroblasts within injured myocardium, serves as the molecular target for FAP inhibitor (FAPI)‐based imaging.
Lan Wang, Shixing Huang, Fengling Shan, Jingjing Lou, Xingdang Liu   +4 more
doaj   +1 more source

PET/CT WITH 68GA-FAPI46 FOR THE DETECTION OF PRIMARY AND METASTATIC LESIONS IN PATIENTS WITH DIFFERENT TYPES OF CANCER. INITIAL EXPERIENCE

Hematology, Transfusion and Cell Therapy
Introduction/Justification: Fibroblast activation protein (FAP), a transmembrane glycoprotein, is over expressed by cancer-associated fibroblasts in the tumor microenvironment.
Lilian Yuri Itaya Yamaga, Gustavo Borges da Silva Teles, Durval Santos, Oren Smaletz, Roberto Pestana, Poliana Biasi, Mauricio Fernandes, Solange Amorim Nogueira, Marycel Figols Barboza, Taise Vitor, Jairo Wagner   +10 more
doaj   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, Volume 13, Issue 38, 9 July 2026.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Enhanced Pancreatitis Detection: FAPI PET/CT Emerging Utility in Patient with Pancreatic Mass

Diagnostics
Fibroblast Activation Protein Inhibitor (FAPI) positron emission tomography (PET) imaging has emerged as a useful method for identifying pancreatic disorders, notably pancreatitis.
Alain Abi Ghanem, Tamara El Annan, Nour El Ghawi, Nadine Omran, Mustafa Natout, Hazem Assi, Ali Shamseddine, Nina Saliba, Mohamad Haidar   +8 more
doaj   +1 more source

A FAP‐Targeted SMDC Platform Enables Synergistic Radionuclide–Chemotherapy with PET‐Guided Evaluation

Advanced Science, Volume 13, Issue 36, 29 June 2026.
A fibroblast activation protein (FAP)‐targeted small molecule–drug conjugate (SMDC) platform is developed to integrate PET imaging with synergistic radionuclide–chemotherapy. Linker chemistry governs stability, exposure, and tolerability, with the VC linker providing superior in vivo performance.
Ruitao Yang, Hongxin Li, Zexin Xu, Baocheng Chen, Ningjie Li, Yuhua Zhong, Kongzhen Hu   +6 more
wiley   +1 more source