Results 51 to 60 of about 5,298,587 (157)

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

68Ga-FAPI Uptake of Thyroiditis in a Patient with Breast Cancer

, 2021
© Wolters Kluwer Health, Inc. All rights reserved.68Ga-fibroblast activation protein-specific inhibitor (FAPI)-04 PET/CT was performed in a 49-year-old woman diagnosed with breast cancer.
Kaplan, İhsan, Can, Canan, Komek, Halil, Guzel, Yunus, Gundogan, Cihan   +4 more
core   +1 more source

In Situ Self‐Assembled Molecular Fortifying Agent for Enhanced Retention and Therapeutic Efficacy of Radiopharmaceuticals

Aggregate, Volume 7, Issue 10, October 2026.
A molecular‐fortifying agent strategy based on in situ self‐assembly is developed to prolong tumor retention of radioligands. After tumor‐targeting, FAP‐α cleavage triggers nanofiber formation, presenting azide anchors for bioorthogonal capture of pre‐accumulated radioligands.
Daojia Liu, Xiaoqin Luo, Xiaojuan Wang, Xing Liu, Fanglei Zhang, Pan Wang, Jibin Song, Junqiang Chen   +7 more
wiley   +1 more source

Integrated Multi‐Time‐Point 18F‐FAPI PET/CT and Immune Histopathology for Predicting Pathological Complete Response in Microsatellite‐Stable Locally Advanced Rectal Cancer Treated With Neoadjuvant Radiotherapy, Chemotherapy, and Immunotherapy

MedComm, Volume 7, Issue 10, October 2026.
Serial multi‐time‐point 18F‐FAPI PET/CT‐derived stromal kinetics and baseline immune‐histopathological features, including iTLS count and B‐cell density, jointly predicted pCR in MSS locally advanced rectal cancer. The resulting four‐variable model achieved a mean nested cross‐validated AUC of 0.874.
Minyi He, Huiting Yang, Yunxing Shi, Rongqin Zhang, Taixuan Wan, Xiaolin Pang, Zhanwen Zhang, Liang Huang   +7 more
wiley   +1 more source

Vooruitgang en toekomstperspectieven van beeldvorming met FAPI-PET/CT

, 2023
Het radiofarmacon 18F-fluorodeoxyglucose (FDG) is momenteel het werkpaard voor PET-diagnostiek. 18F-FDG is een universele tracer voor de diagnostiek van tumoren en infecties, met bijbehorende beperkingen ten aanzien van de specificiteit. De sensitiviteit
Bongers, V, Veldhuijzen van Zanten, Sophie, Jansen, S.M.A.   +2 more
core   +4 more sources

Contemporary Concise Review 2025: Interstitial Lung Disease

Respirology, Volume 31, Issue 10, Page 974-982, October 2026.
ABSTRACT Multidisciplinary discussion remains the cornerstone of ILD diagnosis and management, with recent advances further strengthening the integration of clinical, radiological, pathological, and molecular information. Updated ILD nomenclature and classification better align disease terminology with underlying morphology and pathobiology.
Tonia Magrì, Luca Richeldi
wiley   +1 more source

Can FAPI–PET be used to evaluate cardiac fibroblast activation and predict left ventricular function in patients with cardiovascular diseases? A systematic review and meta-analysis

European Journal of Medical Research
Background Fibroblast activation protein inhibitor (FAPI)–PET is a novel imaging modality that targets FAP. The purpose of this study was to conduct a meta-analysis and synthesize the available data about the sensitivity and specificity of FAPI–PET in ...
Shu Wang, Zhiming Cheng, Hao Sun, Yan Cui, Bulin Du, Yuxuan Zhao, Qiu Luan, Yuxiang Wang, Yaming Li, Xuena Li   +9 more
doaj   +1 more source

Mechanobiological feedback loops and quantitative decision thresholds in organ fibrosis: Translational principles for antifibrotic therapy

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Multiorgan fibrosis arises when chronic injury activates fibroblasts and remodels extracellular matrix, whose increasing stiffness sustains disease through mechanotransduction pathways. Bidirectional cellular‐matrix feedback operates across lung, heart, liver, and kidney.
Amedeo Lonardo, Ralf Weiskirchen
wiley   +1 more source

Intense fibroblast activation protein inhibitor localization around the site of embolized gastroduodenal artery in a patient with metachronous pancreatic adenocarcinoma: A potential pitfall in positron imaging

Acta Radiologica Open
68 Gallium-Fibroblast activation protein inhibitor ( 68 Ga-FAPI) positron emission tomography/computed tomography (PET/CT) is increasingly used for evaluating various epithelial neoplasms.
Ahmed Saad Abdlkadir, Hasan Alalawi, Akram Al-Ibraheem   +2 more
doaj   +1 more source

68Ga-FAPI PET/CT for diagnostic accuracy and therapeutic response assessment in bleomycin-induced pulmonary fibrosis: an integrated preclinical study

Frontiers in Medicine
ObjectiveThis study aimed to assess the diagnostic and therapeutic monitoring potential of 68Ga-fibroblast-activating protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) in bleomycin-induced pulmonary fibrosis (BIPF ...
Rui Sun, Yilin Huang, Hao Deng, Qixin Wang, Canran Xiao, Chunmei Guo, Tianyu Wang, Lisheng Liu, Jun Hua, Xiaoliang Chen   +9 more
doaj   +1 more source