Results 81 to 90 of about 5,298,587 (157)

The FAP+ CAF subset in bladder cancer: A key driver of cancer cell stemness and a promising target for FAPI therapy

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Meiqian Li, Shikun Wang, Hua Xiao, Rong Hu, Yueyun Xie   +4 more
wiley   +1 more source

Clinical applications of fibroblast activation protein inhibitor positron emission tomography (FAPI-PET)

npj Imaging
The discovery of fibroblast activation protein inhibitor positron emission tomography (FAPI-PET) has paved the way for a new class of PET tracers that target the tumor microenvironment (TME) rather than the tumor itself.
Yuriko Mori, Emil Novruzov, Dominik Schmitt, Jens Cardinale, Tadashi Watabe, Peter L. Choyke, Abass Alavi, Uwe Haberkorn, Frederik L. Giesel   +8 more
doaj   +1 more source

18F-FAPI-74 PET/CT findings of an inflammatory branchial cleft cyst mimicking cervical metastasis from carcinoma of unknown primary: A case report

Radiology Case Reports
Fibroblast-activation protein inhibitor (FAPI) positron-emission tomography (PET) is emerging as a promising alternative to 18F-fluorodeoxyglucose (FDG) PET for head-and-neck cancer.
Seiji Oyagi, MD, Tomohiko Yamane, MD, Takuya Yamamoto, MD, Norio Yamamoto, MD, Hara Shigeo, MD, Michio Senda, MD, Masahiro Kikuchi, MD   +6 more
doaj   +1 more source

FAPi PET/CT Imaging to Identify Fibrosis in Immune-Mediated Inflammatory Diseases

Biomedicines
Immune-mediated inflammatory diseases (IMIDs) are characterized by chronic systemic inflammation and multi-organ involvement. Fibrosis formation in IMIDs can cause tissue destruction and subsequently organ malfunction.
Dalia A. Lartey, Lynn A. Schilder, Gerben J. C. Zwezerijnen, Geert R. A. M. D’Haens, Joep Grootjans, Mark Löwenberg   +5 more
doaj   +1 more source

Visualization of Activated Fibroblasts in Heart Failure with Preserved Ejection Fraction with [¹⁸F]AlF-NOTA-FAPI-04 PET/CT Imaging

, 2023
During the pathogenesis of heart failure with preserved ejection fraction (HFpEF), fibroblasts are activated and express the fibroblast activation protein (FAP). Targeted imaging of FAP can qualitatively and quantitatively assess the fibroblast activity.
Chengdong Wang (149015), Fei Yu, Fei Yu (61577), Fangfang Sun, Fangfang Sun (2410654), Pengcheng Zhang (565544), Xinxin Zhang, Xuemei Du, Hongbo Feng (2820331), Chengdong Wang, Hongbo Feng, Xinxin Zhang (309944), Xuemei Du (8162115), Pengcheng Zhang   +13 more
core   +1 more source

Based on small molecules: development and application of fibroblast activation protein inhibitors radiopharmaceutical in tumor precision therapy

Frontiers in Pharmacology
The discovery of biomarkers for malignant tumors is driving the development of new radiopharmaceuticals in nuclear medicine. The development and optimization of novel radiopharmaceuticals to occupy an increasingly important role in tumor diagnosis and ...
Yihui Luo, Haitian Fu, Haitian Fu, Chunjing Yu, Chunjing Yu   +4 more
doaj   +1 more source

Advances in novel imaging agents targeting fibroblast activation proteins [PDF]

Xin yixue
Based on the high target-to-background ratio（TBR），new imaging agents targeting fibroblast activation protein（FAP）have shown better imaging effects in a variety of tumors.
WANG Ning, SHI Yizhen
doaj   +1 more source

Radiolabeled FAPI [PDF]

This chapter describes the interesting role of PET with radiolabeled fibroblast activation protein inhibitors (FAPIs), underlining the potential clinical indications.
Zaidi, Habib, Cimini, Andrea, Ricci, Maria, Travascio, Laura, Dadgar, Habibollah, Arabi, Hossein, Cusella, Fabio, Albalooshi, Batool, Norouzbeigi, Nasim   +8 more
core   +1 more source

Anatomical pattern of entheseal and synovial fibroblast activation in patients with psoriasis and its risk of developing psoriatic arthritis

RMD Open
Objectives To assess the presence and anatomical distribution of activated fibroblasts in the joints and entheses of patients with psoriasis with arthralgia and to test how fibroblast activation visualised by 68gallium-labelled fibroblast activation ...
Georg Schett, Andreas Ramming, Filippo Fagni, Christian Schmidkonz, Armin Atzinger, Arnd Kleyer, Torsten Kuwert, David Simon, Michael Sticherling, Verena Schoenau, Maria Gabriella Raimondo, Melek Yalcin Mutlu, Selahattin Alp Temiz, Rita Noversa de Sousa, Giulia Corte   +14 more
doaj   +1 more source

Positron Emission Tomography with Fibroblast Activation Protein-Targeted Radiopharmaceuticals in Primary Hepatic Tumors: A Systematic Review [PDF]

Background: This systematic review was performed to investigate the potential diagnostic role of fibroblast activation protein (FAP)-targeted radiopharmaceuticals in hepatocarcinoma (HCC) and cholangiocarcinoma (CCA).
De Feo, Maria Silvia, Luca Filippi, De Vincentis, Giuseppe, Lucia Semeraro, Maria Silvia De Feo, Giuseppe De Vincentis, Semeraro, Lucia, Barbara Palumbo, Viviana Frantellizzi, Frantellizzi, Viviana, Filippi, Luca, Palumbo, Barbara, De Vincentis G., De Feo M. S., Semeraro L., Frantellizzi V., Filippi L., Palumbo B.   +17 more
core   +1 more source