Results 11 to 20 of about 5,298,587 (157)

Mesoporous Polydopamine Loaded Pirfenidone Target to Fibroblast Activation Protein for Pulmonary Fibrosis Therapy [PDF]

Frontiers in Bioengineering and Biotechnology, 2022
Recently, fibroblast activation protein (FAP), an overexpressed transmembrane protein of activated fibroblast in pulmonary fibrosis, has been considered as the new target for diagnosing and treating pulmonary fibrosis.
Qi Fang, Shaoyu Liu, Jiangyu Cui, Ruiyue Zhao, Qian Han, Peng Hou, Youcai Li, Jie Lv, Xiaoyao Zhang, Qun Luo, Xinlu Wang   +10 more
doaj   +2 more sources

68Ga-FAPI-04 PET/MR is helpful in differential diagnosis of pancreatitis from pancreatic malignancy compared to 18F-FDG PET/CT: a case report

European Journal of Hybrid Imaging, 2021
Introduction 68Ga-fibroblast activation protein-specific enzyme inhibitor 04 (FAPI-04) is a radiolabelled molecular agent targeting the inhibitor of fibroblast activation protein (FAP), which is often present in tumor stroma and inflammatory tissue with ...
Yi Shou, Qiaoyi Xue, Jianmin Yuan, Jun Zhao   +3 more
doaj   +2 more sources

Delayed 68Ga-FAPI-46 PET/MR imaging confirms ongoing fibroblast activation in patients after acute myocardial infarction

International Journal of Cardiology: Heart & Vasculature
Purpose of the Report: Combined cardiac 68Ga-Fibroblast-Activation Protein-alpha inhibitor (FAPI) positron-emission tomography (PET) and cardiac magnetic resonance imaging (MRI) constitute a novel diagnostic tool in patients for the assessment of ...
Jana Kupusovic, Lukas Kessler, Sandra Kazek, Michal Kamil Chodyla, Lale Umutlu, Fadi Zarrad, Michael Nader, Wolfgang P. Fendler, Zohreh Varasteh, Ken Hermann, Dobromir Dobrev, Reza Wakili, Tienush Rassaf, Johannes Siebermair, Christoph Rischpler   +14 more
doaj   +2 more sources

Locoregional radionuclide therapy of glioblastoma with [211At]At-PDA-FAPI

Scientific Reports
Glioblastoma is the most common and aggressive tumor of the central nervous system. Locoregional administration of therapeutic radiopharmaceuticals appears to be a promising modality for recurrent glioblastomas.
Huan Ma, Tianzhen Ye, Guofeng Qu, Yilin Qin, Jiali Liao, Yuanyou Yang, Wei Zhang, Ning Liu, Feize Li   +8 more
doaj   +2 more sources

Evaluation of Astatine-211-Labeled Fibroblast Activation Protein Inhibitor (FAPI): Comparison of Different Linkers with Polyethylene Glycol and Piperazine. [PDF]

Int J Mol Sci, 2023
Fibroblast activation proteins (FAP) are overexpressed in the tumor stroma and have received attention as target molecules for radionuclide therapy. The FAP inhibitor (FAPI) is used as a probe to deliver nuclides to cancer tissues.
Aso A, Nabetani H, Matsuura Y, Kadonaga Y, Shirakami Y, Watabe T, Yoshiya T, Mochizuki M, Ooe K, Kawakami A, Jinno N, Toyoshima A, Haba H, Wang Y, Cardinale J, Giesel FL, Shimoyama A, Kaneda-Nakashima K, Fukase K.   +18 more
europepmc   +2 more sources

Synovial fibroblast activation occurs before the onset of rheumatoid arthritis and influences the risk of developing disease

RMD Open
Objectives Activated synovial fibroblasts play a key role in rheumatoid arthritis (RA). Positron emission tomography-CT (PET-CT) using 68gallium-labelled fibroblast activation protein inhibitor (FAPI) allows the detection of FAP-expressing activated ...
Georg Schett, Andreas Ramming, Filippo Fagni, Christian Schmidkonz, Armin Atzinger, Arnd Kleyer, Torsten Kuwert, Axel J Hueber, Michael Beck, Koray Tascilar, Sara Bayat, Giulia Corte   +11 more
doaj   +2 more sources

Increased imaging ligand hydrophilicity and improved pharmacokinetic properties provides enhanced in vivo targeting of fibroblast activation protein

npj Imaging
In this work, the impact of physicochemical modifications on pharmacokinetics and in vivo targeting of a small molecule fibroblast activation protein inhibitor (FAPI) imaging ligand in a murine model of rheumatoid arthritis was evaluated.
Radhika Narain, Ian Nessler, Paul L. Richardson, Jamie E. Erickson, Yuzhen Wang, Jacqueline Ferri, Heather L. Knight, Shaughn H. Bryant, Lucy A. Phillips, Liang Zhang, Soumya Mitra   +10 more
doaj   +2 more sources

Molecular Imaging of Fibroblast Activity After Myocardial Infarction Using a ⁶⁸Ga-Labeled Fibroblast Activation Protein Inhibitor, FAPI-04. [PDF]

J Nucl Med, 2019
Heart failure remains a major source of late morbidity and mortality after myocardial infarction (MI). The temporospatial presence of activated fibroblasts in the injured myocardium predicts the quality of cardiac remodeling after MI.
Varasteh Z, Mohanta S, Robu S, Braeuer M, Li Y, Omidvari N, Topping G, Sun T, Nekolla SG, Richter A, Weber C, Habenicht A, Haberkorn UA, Weber WA.   +13 more
europepmc   +2 more sources

The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases: An Updated Systematic Review [PDF]

Pharmaceuticals
The role of fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is emerging for the assessment of non-oncological diseases, such as inflammatory and infectious diseases, even if the evidence in the ...
Domenico Albano, Alessio Rizzo, Riemer H. J. A. Slart, Søren Hess, Edel Noriega-Álvarez, Cristina Gamila Wakfie-Corieh, Lucia Leccisotti, Andor W. J. M. Glaudemans, Olivier Gheysens, Giorgio Treglia   +9 more
doaj   +2 more sources

¹⁸F‑FAPI‑04 PET/CT imaging of fibroblast activating protein reveals myocardial injury beyond cancer staging. [PDF]

Precis Radiat Oncol
Early detection of myocardial injury in cancer patients remains challenging with conventional diagnostic tools. 18F‐FAPI‐04 PET/CT revealed abnormal myocardial uptake associated with cardiovascular risk factors and biomarkers. 18F‐FAPI‐04 PET/CT enables early, noninvasive detection of myocardial injury, providing additional clinical value beyond cancer
Jia J, Zhou C, Yi S, Zheng J, Li C, Qin J, Wei Y.   +6 more
europepmc   +2 more sources