Results 11 to 20 of about 5,708,174 (240)

Discrete microfluidics for the isolation of circulating tumor cell subpopulations targeting fibroblast activation protein alpha and epithelial cell adhesion molecule [PDF]

npj Precision Oncology, 2017
Diagnostics: Dual selection improves circulating tumor cell assay Using two selection markers, instead of one, can improve the sensitivity of a blood test for circulating tumor cells (CTCs). Steven A. Soper from the University of Kansas in Lawrence, USA,
Małgorzata A. Witek, Rachel D. Aufforth, Hong Wang, Joyce W. Kamande, Joshua M. Jackson, Swathi R. Pullagurla, Mateusz L. Hupert, Jerry Usary, Weiya Z. Wysham, Dawud Hilliard, Stephanie Montgomery, Victoria Bae-Jump, Lisa A. Carey, Paola A. Gehrig, Matthew I. Milowsky, Charles M. Perou, John T. Soper, Young E. Whang, Jen Jen Yeh, George Martin, Steven A. Soper   +20 more
doaj   +3 more sources

A synthetic urinary probe–coated nanoparticles sensitive to fibroblast activation protein α for solid tumor diagnosis

International Journal of Nanomedicine, 2017
Xinwei Feng,1,* Qifan Wang,1,* Yuehua Liao,1 Xie Zhou,2 Yidan Wang,3 Wanli Liu,4 Ge Zhang1 1Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 2Department of Medical Chemistry, School ...
Feng XW, Wang QF, Liao YH, Zhou X, Wang YD, Liu WL, Zhang G   +6 more
doaj   +1 more source

Non‐Viral Cytokine‐Inducible SH2 Containing Protein Locus‐Specific Integrated Fibroblast Activation Protein Alpha‐Targeting Chimeric Antigen Receptor T Cells Achieve Potent Antitumor Efficacy in Glioblastoma [PDF]

MedComm
Chimeric antigen receptor T (CAR‐T) cells have been used to treat patients with glioblastoma (GBM) in clinical trial settings by targeting GBM‐associated antigens. However, the efficacy of these CAR‐T cells remains limited mainly due to the heterogeneous
Xin Dong, Yao Sun, Yuetong Guo, Jiao Wang, Fei Wang, Ziming Wang, Ruizhen Li, Fei Xie, Tingting Tan, Baijie Cheng, Ronghan Huang, Shu Zhang, Xiaotong Lin, Zhaoze Guo, Hubing Wu, Hao Wu, Xubiao Zhang, Guozhu Xie   +17 more
doaj   +2 more sources

Anti-Cancer Effect of Targeting Fibroblast Activation Protein Alpha in Glioblastoma Through Remodeling Macrophage Phenotype and Suppressing Tumor Progression [PDF]

CNS Neuroscience and Therapeutics, 2023
Nan Ji, Boyi Hu, Zeping Jin
exaly   +2 more sources

225Ac-Labeled Antibody for Fibroblast Activation Protein-Targeted Alpha Therapy

Chemical & Biomedical Imaging, 2023
Hanbo Song, Mengxin Xu, Jie Cai, Junyi Chen, Yu Liu, Qi Su, Zhu Li, Zhibo Liu   +7 more
doaj   +2 more sources

Targeting fibroblast activation protein-α to treat renal fibrosis

Cellular & Molecular Biology Letters
Background Renal fibrosis is the common outcome of chronic renal disease. Currently, there are no effective therapies. Fibroblast activation and extracellular matrix accumulation are key processes driving renal fibrosis.
Li Gong, Xinyu Lu, Na Ma, Tao Lu, Yuhong Gong, Liwei Hao, Weikang Xu, Qianbing Zhang, Xiaolan Chen, Qinglin Mo, Jiexing Tan, Henrique de Paula Lemos, Alexander Speechley, Wenwei Tu, Jianpiao Cai, Lei Huang, Wei Zhu, Sha Wu   +17 more
doaj   +3 more sources

Identification of Novel Natural Substrates of Fibroblast Activation Protein-Alpha by Differential Degradomics and Proteomics [PDF]

Molecular and Cellular Proteomics, 2019
Quintin Lee, Oliver Schilling, Mark D. Gorrell   +2 more
exaly   +2 more sources

Cross-species evaluation of fibroblast activation protein alpha as potential imaging target for soft tissue sarcoma: a comparative immunohistochemical study in humans, dogs, and cats. [PDF]

Front Oncol, 2023
This collection of data includes microscopic images of canine, feline and human soft tissue sarcoma as well as canine and feline healthy skin and inflammatory tissue samples. Each tissue section was stained using a routine hematoxylin and eosin stain and
Beer P, Pauli C, Haberecker M, Grest P, Beebe E, Fuchs D, Markkanen E, Krudewig C, Nolff MC.   +8 more
europepmc   +2 more sources

Fibroblast heterogeneity in non-small cell lung cancer and optical imaging targeting fibroblast activation protein [PDF]

, 2023
Cancer associated fibroblasts (CAFs) are one of the predominant cell types of non-small cell lung cancer (NSCLC) tumour stroma. This thesis will investigate fibroblast heterogeneity in NSCLC; defining their phenotype by expression of CAF markers ...
Mathieson, Layla
core   +1 more source

Cell-specific expression of the FAP gene is regulated by enhancer elements

Frontiers in Molecular Biosciences, 2023
Fibroblast activation protein (FAP) is an integral membrane serine protease that acts as both dipeptidyl peptidase and collagenase. In recent years, FAP has attracted considerable attention due to its specific upregulation in multiple types of tumor cell
Dina V. Antonova, Dmitry A. Gnatenko, Elena S. Kotova, Victor V. Pleshkan, Victor V. Pleshkan, Alexey I. Kuzmich, Alexey I. Kuzmich, Dmitry A. Didych, Eugene D. Sverdlov, Irina V. Alekseenko, Irina V. Alekseenko, Irina V. Alekseenko   +11 more
doaj   +1 more source