Results 111 to 120 of about 1,957,077 (351)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cellular Players in Gastrointestinal Involvement of Systemic Sclerosis: Insights into Pathogenesis

Cells
Background: Gastrointestinal (GI) involvement is the most frequent visceral complication of systemic sclerosis (SSc), affecting up to 90% of patients, yet it remains poorly understood compared to pulmonary or cutaneous manifestations.
Silvia Peretti, Francesco Bonomi, Giulia Bandini, Cristiano Barbetta, Michael Hughes, Francesco Del Galdo, Marco Matucci Cerinic, Zsuzsanna H. McMahan, Silvia Bellando Randone   +8 more
doaj   +1 more source

MOESM1 of Liver X Receptor Regulates Rheumatoid Arthritis Fibroblast-like Synoviocyte Invasiveness, Matrix Metalloproteinase 2 Activation, Interleukin-6 and CXCL10

, 2018
Liver X Receptor Regulates Rheumatoid Arthritis Fibroblast-like Synoviocyte Invasiveness, Matrix Metalloproteinase 2 Activation, Interleukin-6 and ...
PĂŠrcio Gulko (5840645), Teresina Laragione (4597888)   +1 more
core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Investigating Fibroblast Activation State and Phenotype in Tumor Co-culture Models

, 2022
Fibroblast cells in the tumor microenvironment play a role in cancer cell growth, progression of invasion, and secretion of extracellular matrix components, cytokines, and growth factors.
Priess, Michelle Lynn
core   +1 more source

Adipose Dysfunction Caused by Obesity and Radiation Therapy Rewires the Prostate Stroma Toward Tumor Progression

Cells
Obesity is associated with chronic adipose dysfunction characterized by oxidative stress, inflammation, senescence, and fibrosis, which can promote tumor progression.
Simran Takkar, Louise Monga-Wells, Arpita Chatterjee, Subodh M. Lele, Rebecca E. Oberley-Deegan   +4 more
doaj   +1 more source

Persistent stromal fibroblast activation is present in chronic tendinopathy [PDF]

, 2017
Background Growing evidence supports a key role for inflammation in the onset and progression of tendinopathy. However, the effect of the inflammatory infiltrate on tendon cells is poorly understood.
Buckley, Christopher, Martinez, Fernando, Mohammad Hussein Al-Mossawi, Carr, Andrew, Fernando O. Martinez, Carr, A, Bridget Watkins, Andrew J. Carr, Hedley, Robert, Dakin, Stephanie G., Dakin, Stephanie, Stephanie G. Dakin, Al-Mossawi, Mohammad Hussein, Wheway, Kim, Wheway, K, Kim Wheway, Watkins, Bridget, Christopher D. Buckley, Hussein Al-Mossawi, Mohammad, O. Martinez, Fernando, Robert Hedley, Buckley, CD, Dakin, SG   +22 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation–Ubiquitylation Crosstalk of HMGA2

Advanced Science
Ovarian cancer is an aggressive gynecological tumor usually diagnosed with widespread metastases. Extracellular vesicles (EVs), though recognized as important mediators of tumor metastasis, have received limited attention into their specific functions ...
Lingkai Gu, Zhangjin Shen, Shizhen Shen, Conghui Wang, Yuwan Liu, Xinyi Wei, Mengxia Zheng, Jiaxin Gu, Xiaojing Chen, Yi Sun, Junfen Xu, Yan Lu, Weiguo Lu   +12 more
doaj   +1 more source