Results 91 to 100 of about 5,708,203 (270)

Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study

Respiratory Research, 2009
Background Toll-like receptor 4 (TLR4) is essential in lipopolysaccharide (LPS)-induced fibroblast activation and collagen secretion in vitro. However, its effects on the process of lung fibroblast activation and fibrosis initiation during LPS induced ...
Jiang Hong, Zhu YeSen, He ZhengYu
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Oxidative stress stimulates alpha-tocopherol transfer protein in human trophoblast tumor cells BeWo [PDF]

, 2012
alpha-Tocopherol transfer protein (alpha-TTP) has been identified as the major intracellular transport protein for the antioxidant vitamin E (alpha-Tocopherol).
Etzl, Ronny P., Vrekoussis, Thomas, Rotzoll, Daisy E., Jeschke, Udo, Schulze, Sandra, Poeschl, Johannes M., Kuhn, Christina, Makrigiannakis, Antonis   +7 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

ZNF469 drives TGF-β1/SMAD3-mediated extracellular matrix regulation in pulmonary fibrosis

Biomolecules & Biomedicine
Pulmonary fibrosis is characterized by persistent activation of lung fibroblasts and excessive extracellular matrix (ECM) deposition; however, the transcriptional mechanisms sustaining this activated state remain poorly understood. Given the established
Thammachanok Boonto, Nucharnart Suntornnont, Archittapon Nokkeaw, Chaiyaboot Ariyachet, Amornpun Wongkarnjana   +4 more
doaj   +1 more source

Biomarkers of Progression after HIV Acute/Early Infection: Nothing Compares to CD4+ T-cell Count?

Viruses, 2018
Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees.
Gabriela Turk, Yanina Ghiglione, Macarena Hormanstorfer, Natalia Laufer, Romina Coloccini, Jimena Salido, César Trifone, María Julia Ruiz, Juliana Falivene, María Pía Holgado, María Paula Caruso, María Inés Figueroa, Horacio Salomón, Luis D. Giavedoni, María de los Ángeles Pando, María Magdalena Gherardi, Roberto Daniel Rabinovich, Pedro A. Pury, Omar Sued   +18 more
doaj   +1 more source

P01.01EXPRESSION OF FIBROBLAST ACTIVATION PROTEIN ALPHA IN HUMAN HIGH-GRADE GLIOMAS [PDF]

Neuro Oncol, 2014
Fibroblast activation protein alpha (FAP) is a dual specificity serine protease that is strongly associated with the development and progression of human carcinomas and represents a potential stromal target for anticancer treatment. Due to its gelatinolytic activity, FAP may participate in matrix-degradation, thus contributing to cell invasion.
E. Balaziova, P. Busek, M. Hilser, I. Vomelova, L. Sromova, E. Krepela, A. Sedo   +6 more
europepmc   +3 more sources

LAM nodules express fibroblast markers.

, 2015
LAM nodules react with antibodies against alpha-Smooth Muscle Actin, Fibroblast Surface Protein (FSP), Fibroblast Activation Protein (FAP) and S100A4.
Arundhati Dongre (529194), Vera P. Krymskaya (188111), Simon R. Johnson (529197), Debbie Clements (529193)   +3 more
core   +1 more source

Therapeutic Effects of Omentin-1 on Pulmonary Fibrosis by Attenuating Fibroblast Activation via AMP-Activated Protein Kinase Pathway

, 2022
Idiopathic pulmonary fibrosis (IPF) is a fatal age-related chronic lung disease, characterized by progressive scarring of the lungs by activated fibroblasts.
Haipeng Cheng, Shaojie Yue, Zhou, Yan, Xiaohong Li, Cheng, Haipeng, Yan Zhou, Yunna Zhang, Hui Xie, Li, Xiaohong, Jianping Xu, Luo, Ziqiang, Yue, Shaojie, Feng, Dandan, Ziqiang Luo, Dandan Feng, Zhang, Yunna, Xu, Jianping, Xie, Hui   +17 more
core   +1 more source