Results 91 to 100 of about 547,171 (369)

A model for one-dimensional morphoelasticity and its application to fibroblast-populated collagen lattices [PDF]

, 2017
The mechanical behaviour of solid biological tissues has long been described using models based on classical continuum mechanics. However, the classical continuum theories of elasticity and viscoelasticity cannot easily capture the continual remodelling and associated structural changes of biological tissues.
arxiv   +1 more source

Fibroblast Growth Factor-23 and Risks of Cardiovascular and Noncardiovascular Diseases: A Meta-Analysis.

Journal of the American Society of Nephrology, 2018
Background Fibroblast growth factor-23 (FGF-23) has been hypothesized to play a role in the increased risk of cardiovascular disease in patients with CKD.Methods We identified prospective studies reporting associations between FGF-23 concentration and ...
Amarnath Marthi, Killian Donovan, R. Haynes, D. Wheeler, C. Baigent, C. Rooney, M. Landray, S. Moe, Jun Yang, L. Holland, R. di Giuseppe, Annet Bouma-de Krijger, B. Mihaylova, W. Herrington   +13 more
semanticscholar   +1 more source

Clinical Potential of Targeting Fibroblast Growth Factor‐23 and αKlotho in the Treatment of Uremic Cardiomyopathy

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2020
Chronic kidney disease is highly prevalent, affecting 10% to 15% of the adult population worldwide and is associated with increased cardiovascular morbidity and mortality.
Jonathan P. Law, A. Price, L. Pickup, A. Radhakrishnan, C. Weston, Alan M. Jones, H. McGettrick, W. Chua, R. Steeds, L. Fabritz, P. Kirchhof, D. Pavlovic, J. Townend, C. Ferro   +13 more
semanticscholar   +1 more source

An Unusual Combination of Neurological Manifestations and Sudden Vision Loss in a Child with Familial Hyperphosphatemic Tumoral Calcinosis [PDF]

, 2019
Hyperphosphatemia in the absence of renal failure is an unusual occurrence, particularly in children, but is a common primary feature of familial hyperphosphatemic tumor calcinosis.
Acton, Dena, Evans, Michael J., Gray, Amie K., Ichikawa, Shoji, Kekunnaya, Ramesh, Lingappa, Lokesh, Madarasu, Rajsekara Chakravarthi, Siddaiahagari, Sirisharani   +7 more
core   +1 more source

Gla-rich protein (GRP) as an early and novel marker of vascular calcification and kidney dysfunction in diabetic patients with CKD: a pilot cross-sectional study [PDF]

, 2020
Vascular calcification (VC) is one of the strongest predictors of cardiovascular risk in chronic kidney disease (CKD) patients. New diagnostic/prognostic tools are required for early detection of VC allowing interventional strategies.
Almeida, Edgar de, Dias, Carolina, Faísca, Marília, Guilherme, Patrícia, Macedo, Ana, Mendes, Filipa, Neves, Pedro Leão, Rato, Fátima, Santos, Nélio, Silva, Ana P., Simes, Dina, Tavares, Nelson, Viegas, Carla   +12 more
core   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production

Kidney International, 2015
Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with chronic kidney disease (CKD), but the mechanisms are poorly understood. Here we tested whether inflammation and iron deficiency regulate FGF23.
V. David, Aline Martin, T. Isakova, Christina Spaulding, Lixin Qi, Veronica Ramirez, Kimberly B. Zumbrennen-Bullough, C. C. Sun, Herbert Y. Lin, Jodie L Babitt, M. Wolf   +10 more
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Is Fibroblast growth factor 23 the leading cause of increased mortality among chronic kidney disease patients? A narrative review

Journal of Advanced Research, 2017
The death rate among chronic kidney disease patients is the highest compared to other chronic diseases. 60% of these fatalities are cardiovascular. Cardiovascular calcifications and chronic inflammation affect almost all chronic kidney disease patients ...
Usama A.A. Sharaf El Din, Mona M. Salem, Dina O. Abdulazim   +2 more
doaj   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source