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Fibroblast Growth Factor 23 (FGF23) and the kidney

The International Journal of Artificial Organs, 2009
Phosphate homeostasis in humans is a complex phenomenon involving the interplay of several different organs and circulating hormones. Among the latter, parathyroid hormone (PTH), and vitamin D3 (Vit D3) were thought to be the main regulators of serum phosphate concentration since they mediated the intestinal, renal and bone responses that follow ...
George, Tsagalis   +3 more
openaire   +2 more sources

The phosphate regulating hormone fibroblast growth factor‐23

Acta Physiologica, 2010
AbstractOver the last decade, the regulation of phosphate (Pi) homeostasis has been under intense investigation. By utilizing modern biochemical and genetic tools, the pathophysiological mechanisms behind several known hereditary and acquired hypo‐ and hyperphosphatemic diseases have been clarified. The results of these efforts have opened new insights
R, Marsell, K B, Jonsson
openaire   +2 more sources

Fibroblast growth factor 23 enhances renal klotho abundance

Pflügers Archiv - European Journal of Physiology, 2013
Klotho constitutes the receptor for fibroblast growth factor 23 (FGF23). However, the effects of FGF23 on renal and circulating klotho are not well-known. In vivo experiments were performed to assess the effects of FGF23 (10 μg/kg), parathyroid hormone (PTH, 10 μg/kg), and 1,25-dihydroxy-vitamin D3 (1,25VD, 1 μg/kg) on renal expression and serum ...
Tsuneo, Takenaka   +4 more
openaire   +2 more sources

The couple fibroblast growth factor 23 (FGF23)/Klotho

Annales de biologie clinique, 2015
The fibrobalst growth factor 23 (FGF23) is a protein secreted in the plasma by bone cells. FGF23 controls phosphate and calcitriol plasma concentration. Its main physiological targets are the kidney and the parathyroid gland. Its production is stimulated by phosphate intake and plasma calcitriol levels.
openaire   +2 more sources

Fibroblast Growth Factor-23 and Phosphorus Metabolism

2011
The understanding of phosphorus metabolism has expanded considerably over the last decade. Recent studies have identified a novel bone-kidney endocrine axis that maintains phosphate homeostasis. When phosphate is in excess, FGF-23 is secreted from bone and acts on the kidney to promote phosphate excretion into urine and to suppress vitamin D synthesis,
openaire   +2 more sources

Fibroblast Growth Factor 23 and CKD Prognosis

American Journal of Kidney Diseases, 2012
Navdeep, Tangri, Andrew S, Levey
openaire   +2 more sources

Cancer treatment and survivorship statistics, 2022

Ca-A Cancer Journal for Clinicians, 2022
Kimberly D Miller   +2 more
exaly  

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