Results 71 to 80 of about 547,171 (369)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Expression of basic fibroblast growth factor is associated with poor outcome in non-Hodgkin's lymphoma [PDF]

It is now clear that angiogenesis and angiogenesis factors are important in the pathogenesis of haematological malignancies. High pretreatment levels of serum basic fibroblast growth factor have been shown to be associated with poor prognosis in patients
A Bikfalvi, A Vacca, C Basilico, C Tzabar, C Yiangou, D Birnbaum, D Giri, D Ribatti, E Okon, E Rabizadeh, F Dellacono, G Gruber, I Pazgal, J Folkman, K Yamazaki, M Shaklai, M Toi, M Volm, MH Mangi, ML Iruela-Arispe, NL Harris, O Bairey, O Sezer, P Salven, RT Poon, T Menzel, T Ohta, VD Blanckaert, Y Zimra   +28 more
core   +2 more sources

Predictors of intact and C-terminal fibroblast growth factor 23 in Gambian children [PDF]

, 2013
Elevated C-terminal fibroblast growth factor 23 (C-FGF23) concentrations have been reported in Gambian children with and without putative Ca-deficiency rickets.
Assar, Shima, Braithwaite, Vickie, Jones, Kerry S, Prentice, Ann, Schoenmakers, Inez   +4 more
core   +1 more source

Erythropoietin, Fibroblast Growth Factor 23, and Death After Kidney Transplantation [PDF]

, 2020
Elevated levels of erythropoietin (EPO) are associated with an increased risk of death in renal transplant recipients (RTRs), but the underlying mechanisms remain unclear.
Bakker, Stephan J L, De Borst, Martin H, De Jong, Maarten A, Eisenga, Michele F, Gaillard, Carlo A J M, Leaf, David E, Nolte, Ilja M   +6 more
core   +1 more source

PKC regulates the production of fibroblast growth factor 23 (FGF23).

PLoS ONE, 2019
Serine/threonine protein kinase C (PKC) is activated by diacylglycerol that is released from membrane lipids by phospholipase C in response to activation of G protein-coupled receptors or receptor tyrosine kinases.
Ludmilla Bär, Philipp Hase, Michael Föller   +2 more
doaj   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Fibroblast growth factor-23 in patients with systemic sclerosis: A case–control study [PDF]

, 2016
BackgroundFibroblast growth factor-23 (FGF-23) is actively involved in phosphate homeostasis and skeletogenesis.Aim of the workTo assess the serum level of FGF-23 in systemic sclerosis (SSc) patients (both diffuse dSSc and limited lSSc subtypes) in order
Kamali Sarvestani, E., Nazarinia, M.A., Omrani, Gholamhossein R., Radmanesh, Sara, Shenavandeh, Saeedeh   +4 more
core   +1 more source

Role of Fibroblast Growth Factor-23 in Innate Immune Responses

Frontiers in Endocrinology, 2018
Fibroblast growth factor-23 (FGF-23) is a bone-derived hormone that activates FGFR/α-Klotho binary complexes in the kidney renal tubules to regulate phosphate reabsorption and vitamin D metabolism.
Elizabeth A. Fitzpatrick, Xiaobin Han, Zhousheng Xiao, L. Darryl Quarles   +3 more
doaj   +1 more source

Oncogenic Osteomalacia: An Approach to Diagnosis with a Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2017
Oncogenic osteomalacia, also known as tumour induced osteomalacia, is a rare paraneoplastic syndrome caused by mesenchymal tumours secreting Fibroblast Growth Factor-23 (FGF-23).
Biswajit Dey, Debasis Gochhait, Hema Subramanian, Madhusudhanan Ponnusamy   +3 more
doaj   +1 more source

Roles of osteocytes in phosphate metabolism

Frontiers in Endocrinology, 2022
Osteocytes are dendritic cells in the mineralized bone matrix that descend from osteoblasts. They play critical roles in controlling bone mass through the production of sclerostin, an inhibitor of bone formation, and receptor activator of nuclear factor ...
Toshimi Michigami
doaj   +1 more source