Results 91 to 100 of about 1,606,538 (419)

Toward a Novel Endogenous Anxiolytic Factor, Fibroblast Growth Factor 2 [PDF]

Biological Psychiatry, 2011
Among the 26% of Americans that showed a 12-month prevalence for a DSM-IV psychiatric disorder in 2005, most suffered from anxiety disorders (18.1%), followed by mood disorders at 9.5% (1). Therefore, anxiety disorders affect nearly one fifth of the population directly in their lifetime, albeit with substantial variation in range of affliction. Despite
Flora M. Vaccarino, Natalina Salmaso
openaire   +3 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation.

Journal of Clinical Investigation, 2000
Basic fibroblast growth factor (FGF-2), an important modulator of cartilage and bone growth and differentiation, is expressed and regulated in osteoblastic cells.
A. Montero, Y. Okada, M. Tomita, Masako Ito, H. Tsurukami, Toshitaka Nakamura, T. Doetschman, J. Coffin, M. Hurley   +8 more
semanticscholar   +1 more source

In Vitro Assessment of Wound-Healing Efficacy of Stabilized Basic Fibroblast Growth Factor (FGF-2) Solutions

Pharmaceuticals
Chronic tympanic membrane perforations (TMP) pose a significant clinical challenge, but basic fibroblast growth factor (FGF-2) shows promise for their treatment, despite its instability in aqueous solutions which hampers the sustained delivery crucial ...
Leah Benington, Jingxin Mo, Mingxin Li, Gunesh Rajan, Cornelia Locher, Lee Yong Lim   +5 more
doaj   +1 more source

Fibroblast Growth Factor 21 in Gestational Diabetes Mellitus and Type 2 Diabetes Mellitus

Journal of Diabetes Research, 2023
Objective. Women who develop GDM present a metabolic condition similar to that found in type 2 diabetes, characterized by impaired insulin response. Due to similar pathophysiologic mechanisms found between type 2DM and GDM, there is a great interest in ...
Katarzyna Gawlik, Tomasz Milewicz, Dorota Pawlica-Gosiewska, Iwona Trznadel-Morawska, Bogdan Solnica   +4 more
doaj   +1 more source

Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo [PDF]

, 2007
Endothelial cell survival is indispensable to maintain endothelial integrity and initiate new vessel formation. We investigated the role of SHP-2 in endothelial cell survival and angiogenesis in vitro as well as in vivo.
Alavi A, Barbara Walzog, Bennett AM, Brooks PC, Chan RJ, Chang F, Chen J, Christian Plank, Crompton T, Cunnick JM, Distler JH, Florian Krötz, Frisch SM, Hadari YR, Hae-Young Sohn, Hanna Mannell, Hu Y, Huang P, Ivins Zito C, Kontaridis MI, Krotz F, Krotz F, Krotz F, Krotz F, Leopold Groesser, Munoz-Chapuli R, Neel BG, Neel BG, Nicole Hellwig, Noguchi T, Nor JE, Ong SH, O’Brien CD, Papetti M, Plank C, Qi JH, Qi JH, Qu CK, Ren Y, Saxton TM, Shi ZQ, Slater EP, Tang TL, Thakker GD, Tomanek RJ, Torsten Gloe, Ulrich Pohl, Wu CJ, Yart A, Zhang SQ, Zhang SQ   +50 more
core   +1 more source

Prostaglandins Regulate the Expression of Fibroblast Growth Factor-2 in Bone [PDF]

Endocrinology, 1999
We examined the effect of PGs, particularly PGF2alpha, on basic fibroblast growth factor-2 (FGF-2) messenger RNA (mRNA) and protein in the rat osteoblastic cell line Py1a and in fetal rat calvariae. Py1a cells expressed multiple FGF-2 mRNA transcripts. PGF2alpha dose-dependently increased the 6-kb transcript at 6 h.
SABBIETI, Maria Giovanna, MARCHETTI, Luigi, ABREU C., MONTERO A., HAND A. R, RAISZ L. G., HURLEY M. M.   +6 more
openaire   +3 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease

Bone Research, 2021
Bone-produced fibroblast growth factor 23 (FGF23) increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease (CKD). Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin 2; LCN2
Guillaume Courbon, Connor Francis, Claire Gerber, Samantha Neuburg, Xueyan Wang, Emily Lynch, Tamara Isakova, Jodie L. Babitt, Myles Wolf, Aline Martin, Valentin David   +10 more
doaj   +1 more source