Results 221 to 230 of about 255,577 (258)

Determination of fibroblast growth factor 23

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2009
Background Fibroblast growth factor 23 (FGF-23) is a recently discovered hormone, which plays a key role in phosphate regulation. To investigate whether FGF-23 can be determined reliably, we validated the three available FGF-23 assays. Methods
Heijboer, Annemieke C., Levitus, Marieke, Vervloet, Marc G., Lips, Paul, ter Wee, Piet M., Dijstelbloem, Hilde M., Blankenstein, Marinus A.   +6 more
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Fibroblast Growth Factor 23 in CKD [PDF]

Clinical Journal of the American Society of Nephrology
Mandy Wan, Uwe Querfeld, Franz Schaefer, Rukshana Shroff   +3 more
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Fibroblast growth factor 23 and the heart

Current Opinion in Nephrology and Hypertension, 2012
Elevated serum levels of the phosphaturic hormone fibroblast growth factor 23 (FGF23) are strongly associated with chronic kidney disease (CKD) progression and mortality, and are also independently associated with left ventricular hypertrophy, a major contributor to cardiovascular disease (CVD) and death in CKD patients.
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Fibroblast Growth Factor 23 and Its Receptors

Therapeutic Apheresis and Dialysis, 2005
Abstract:  Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Autosomal dominant hypophosphatemic rickets is characterized by hypophosphatemia with inappropriately ...
Xijie, Yu, Kenneth E, White
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Kidney clearance of fibroblast growth factor-23 in humans

Current Opinion in Nephrology & Hypertension, 2023
Purpose of review Recent studies have shed light on factors influencing FGF23 regulation in terms of its production and cleavage. However, less is known about FGF23 elimination from circulation. The kidney's role in FGF23 elimination will be the focus of this review. Recent findings
Shilpa, Sharma, Joachim H, Ix
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Fibroblast growth factor 23 and phosphate homeostasis

Current Opinion in Nephrology and Hypertension, 2019
The current review highlights recent advances in the area of renal tubular phosphate transport and its regulation by fibroblast growth factor 23 (FGF23), a potent regulator of phosphate homeostasis.Recent studies demonstrate that FGF23 binds to both membrane and soluble form of α-klotho to activate FGF receptor signaling pathways.
Shanthi, Balani, Farzana, Perwad
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Fibroblast Growth Factor 23 (FGF23) and the kidney

The International Journal of Artificial Organs, 2009
Phosphate homeostasis in humans is a complex phenomenon involving the interplay of several different organs and circulating hormones. Among the latter, parathyroid hormone (PTH), and vitamin D 3 (Vit D 3 ) were thought to be the main regulators of serum
George, Tsagalis, Erasmia, Psimenou, Efstathios, Manios, Antonios, Laggouranis   +3 more
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Phosphate wasting and fibroblast growth factor-23

Current Opinion in Endocrinology, Diabetes & Obesity, 2013
The purpose of this study is to review the regulation of phosphate and recent progress in fibroblast growth factor-23 (FGF-23), a key phosphate regulatory hormone.Phosphate is required for mineralization of bone, muscle strength and a host of biologic functions. Phosphate is sensed by bone that responds with secretion of FGF-23. The major action of FGF-
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Fibroblast Growth Factor 23 and Klotho Are Present in the Growth Plate

Connective Tissue Research, 2013
Regulation of phosphate homeostasis is essential for mineralization and enchondral ossification. Fibroblast growth factor 23 (FGF23) and its obligatory co-receptor Klotho (KL) play a key role in this process by influencing both renal phosphate reabsorption and vitamin D metabolism. In disease, excessive action of FGF23 leads to hypophosphatemic rickets,
Adalbert, Raimann, Diana Alexandra, Ertl, Magdalena, Helmreich, Susanne, Sagmeister, Monika, Egerbacher, Gabriele, Haeusler   +5 more
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Inherited fibroblast growth factor 23 excess

Best Practice & Research Clinical Endocrinology & Metabolism
Syndromes of inherited fibroblast growth factor 23 (FGF-23) excess encompass a wide spectrum that includes X-linked hypophosphataemia (XLH), autosomal dominant and recessive forms of rickets as well as various syndromic conditions namely fibrous dysplasia/McCune Albright syndrome, osteoglophonic dysplasia, Jansen's chondrodysplasia and cutaneous ...
Kripa Elizabeth, Cherian, Thomas Vizhalil, Paul   +1 more
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