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Fibroblast growth factor 23 and bone mineralisation [PDF]
International Journal of Oral Science, 2015 Fibroblast growth factor 23 (FGF23) is a hormone that is mainly secreted by osteocytes and osteoblasts in bone. The critical role of FGF23 in mineral ion homeostasis was first identified in human genetic and acquired rachitic diseases and has been further characterised in animal models.
Guo, Yu-Chen, Yuan, Quan
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Fibroblast-growth factor 23 promotes terminal differentiation of ATDC5 cells. [PDF]
PLoS ONE, 2017 Fibroblast Growth Factor 23 (FGF23) is well documented as a crucial player in the systemic regulation of phosphate homeostasis. Moreover, loss-of-function experiments have revealed that FGF23 also has a phosphate-independent and local impact on ...
Mathilde Guibert +3 more
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Fibroblast growth factor 23, klotho and heparin
Current Opinion in Nephrology & Hypertension, 2023 Purpose of review Fibroblast growth factor (FGF) 23 is a bone-derived hormone that regulates phosphate and vitamin D metabolism by targeting the kidney. When highly elevated, such as in chronic kidney disease (CKD), FGF23 can also target the heart and induce pathologic remodeling.
Thomas, S. Madison +2 more
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Fibroblast Growth Factor-23 and a Vegetarian Diet [PDF]
Journal of Renal Nutrition, 2020 Sparse data exist on population distributions of serum fibroblast growth factor-23 (FGF23) levels from developing, middle-income economies. FGF23 levels may differ substantially across regions based on differences in diet and urbanization. In a population-based study from North India, we tested the hypothesis that urinary phosphate excretion and FGF23 ...
Shuchi Anand +5 more
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Role of Fibroblast Growth Factor 23 (FGF23) and αKlotho in Cancer
Frontiers in Cell and Developmental Biology, 2021 Together with fibroblast growth factors (FGFs) 19 and 21, FGF23 is an endocrine member of the family of FGFs. Mainly secreted by bone cells, FGF23 acts as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3 ...
Franz Ewendt +2 more
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Fibroblast Growth Factor 23 and the Last Mile [PDF]
Clinical Journal of the American Society of Nephrology, 2020 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphorus balance by enhancing urinary phosphorus excretion and inhibiting the synthesis of 1,25-dihydroxyvitamin D [1,25(OH)2D] ([1][1]).
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How Fibroblast Growth Factor 23 Works [PDF]
Journal of the American Society of Nephrology, 2007 There is a discontinuum of hereditary and acquired disorders of phosphate homeostasis that are caused by either high or low circulating levels of the novel phosphaturic hormone fibroblastic growth factor 23 (FGF23). Disorders that are caused by high circulating levels of FGF23 are characterized by hypophosphatemia, decreased production of 1,25 ...
Shiguang, Liu, L Darryl, Quarles
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Frontiers in Physiology, 2020 Dietary phosphorus oversupply wastes non-renewable natural resources and raises environmental concerns in animal agriculture. We hypothesized that laying hens do not need large safety margins for dietary phosphorus because of the existence of fibroblast ...
Zhouzheng Ren +8 more
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A rare cause of atraumatic fractures: case series of four patients with tumor-induced osteomalacia
Clinical Diabetes and Endocrinology, 2020 Background Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome that presents with hypophosphatemia, bone pain, muscle weakness and fractures.
Debbie W. Chen +4 more
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Fibroblast growth factor 23: fueling the fire [PDF]
Kidney International, 2016 In chronic kidney disease, systemic inflammation is common and associated with mortality. The present study demonstrates that fibroblast growth factor 23 (FGF23) contributes to uremic inflammation by increasing hepatic expression and secretion of inflammatory cytokines.
Hanudel, Mark +2 more
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