Results 331 to 340 of about 961,893 (364)

Fibroblast growth factor 23 and phosphate homeostasis

Current Opinion in Nephrology and Hypertension, 2019
The current review highlights recent advances in the area of renal tubular phosphate transport and its regulation by fibroblast growth factor 23 (FGF23), a potent regulator of phosphate homeostasis.Recent studies demonstrate that FGF23 binds to both membrane and soluble form of α-klotho to activate FGF receptor signaling pathways.
Shanthi Balani, Farzana Perwad
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Fibroblast growth factor 23 and the heart

Current Opinion in Nephrology and Hypertension, 2012
Elevated serum levels of the phosphaturic hormone fibroblast growth factor 23 (FGF23) are strongly associated with chronic kidney disease (CKD) progression and mortality, and are also independently associated with left ventricular hypertrophy, a major contributor to cardiovascular disease (CVD) and death in CKD patients.
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Fibroblast Growth Factor 23 (FGF23) and the kidney

The International Journal of Artificial Organs, 2009
Phosphate homeostasis in humans is a complex phenomenon involving the interplay of several different organs and circulating hormones. Among the latter, parathyroid hormone (PTH), and vitamin D3 (Vit D3) were thought to be the main regulators of serum phosphate concentration since they mediated the intestinal, renal and bone responses that follow ...
George Tsagalis, Erasmia Psimenou, Antonios Laggouranis, Efstathios Manios   +3 more
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Phosphate wasting and fibroblast growth factor-23

Current Opinion in Endocrinology, Diabetes & Obesity, 2013
The purpose of this study is to review the regulation of phosphate and recent progress in fibroblast growth factor-23 (FGF-23), a key phosphate regulatory hormone.Phosphate is required for mineralization of bone, muscle strength and a host of biologic functions. Phosphate is sensed by bone that responds with secretion of FGF-23. The major action of FGF-
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Fibroblast Growth Factor 23 and Klotho Are Present in the Growth Plate

Connective Tissue Research, 2013
Regulation of phosphate homeostasis is essential for mineralization and enchondral ossification. Fibroblast growth factor 23 (FGF23) and its obligatory co-receptor Klotho (KL) play a key role in this process by influencing both renal phosphate reabsorption and vitamin D metabolism. In disease, excessive action of FGF23 leads to hypophosphatemic rickets,
Susanne Sagmeister, Diana Alexandra Ertl, M. Helmreich, Adalbert Raimann, Gabriele Haeusler, Monika Egerbacher   +5 more
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Inherited fibroblast growth factor 23 excess

Best Practice & Research Clinical Endocrinology & Metabolism
Syndromes of inherited fibroblast growth factor 23 (FGF-23) excess encompass a wide spectrum that includes X-linked hypophosphataemia (XLH), autosomal dominant and recessive forms of rickets as well as various syndromic conditions namely fibrous dysplasia/McCune Albright syndrome, osteoglophonic dysplasia, Jansen's chondrodysplasia and cutaneous ...
Kripa Elizabeth, Cherian, Thomas Vizhalil, Paul   +1 more
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Fibroblast growth factor 23 as a phosphotropic hormone and beyond

Journal of Bone and Mineral Metabolism, 2011
Fibroblast growth factor 23 (FGF23) is produced by bone and reduces serum phosphate by inhibiting proximal tubular phosphate reabsorption and intestinal phosphate absorption. Excess actions of FGF23 cause several kinds of hypophosphatemic rickets/osteomalacia while deficient actions of FGF23 result in hyperphosphatemic tumoral calcinosis.
Seiji Fukumoto, Yuichiro Shimizu
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Renal and extrarenal effects of fibroblast growth factor 23

Nature Reviews Nephrology, 2018
Fibroblast growth factor 23 (FGF23) is a hormone with a central role in the regulation of phosphate homeostasis. This regulation is accomplished by the coordinated modulation of renal phosphate handling, vitamin D metabolism and parathyroid hormone secretion.
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Fibroblast Growth Factor-23 and Phosphorus Metabolism

2011
The understanding of phosphorus metabolism has expanded considerably over the last decade. Recent studies have identified a novel bone-kidney endocrine axis that maintains phosphate homeostasis. When phosphate is in excess, FGF-23 is secreted from bone and acts on the kidney to promote phosphate excretion into urine and to suppress vitamin D synthesis,
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The couple fibroblast growth factor 23 (FGF23)/Klotho

Annales de biologie clinique, 2015
The fibrobalst growth factor 23 (FGF23) is a protein secreted in the plasma by bone cells. FGF23 controls phosphate and calcitriol plasma concentration. Its main physiological targets are the kidney and the parathyroid gland. Its production is stimulated by phosphate intake and plasma calcitriol levels.
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