Results 301 to 310 of about 529,025 (348)

Fibroblast Growth Factor 23 and Its Receptors

Therapeutic Apheresis and Dialysis, 2005
Abstract:  Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Autosomal dominant hypophosphatemic rickets is characterized by hypophosphatemia with inappropriately ...
Xijie Yu, Kenneth E. White
openaire   +3 more sources

Cellular signaling by fibroblast growth factor receptors

Cytokine & Growth Factor Reviews, 2005
The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4.
Veraragavan P. Eswarakumar, Joseph Schlessinger, Irit Lax   +2 more
openaire   +3 more sources

Fibroblast Growth Factors and Their Receptors in Parathyroid Disease

World Journal of Surgery, 1998
AbstractFibroblast growth factors (FGFs) comprise a family of polypeptide growth factors implicated in the control of proliferation of glandular tissues. The aim of this study was to determine whether FGFs are produced in normal and abnormal parathyroid glands and if these tissues have the potential to respond to this growth factor family.
Colby L. Eaton, Barnard J. Harrison, Darren Lambert   +2 more
openaire   +3 more sources

Immunohistochemical localization of growth factors fibroblast growth factor-1 and fibroblast growth factor-2 and receptors fibroblast growth factor receptor-2 and fibroblast growth factor receptor-3 in normal oral epithelium, epithelial dysplasias, and squamous cell carcinoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2002
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been identified in a variety of carcinomas, but there are few studies concerning their presence in oral cancers. The objective of this study was to determine whether FGF-1, FGF-2, and high affinity receptors FGFR2 and FGFR3 are present in the pathogenesis of oral epithelial dysplasias ...
Linda Jackson-Boeters, George P. Wysocki, Candice A Wakulich, Tom D. Daley   +3 more
openaire   +3 more sources

Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Journal of Medicinal Chemistry, 2011
A novel series of N-aryl-N'-pyrimidin-4-yl ureas has been optimized to afford potent and selective inhibitors of the fibroblast growth factor receptor tyrosine kinases 1, 2, and 3 by rationally designing the substitution pattern of the aryl ring.
V. Guagnano, P. Furet, C. Spanka, V. Bordas, Mickaël Le Douget, C. Stamm, J. Brueggen, M. Jensen, C. Schnell, Herbert A. Schmid, M. Wartmann, J. Berghausen, P. Drueckes, A. Zimmerlin, D. Bussiere, J. Murray, Diana Graus Porta   +16 more
semanticscholar   +1 more source

The Role of Fibroblast Growth Factor Receptors in Cancer

2021
Breast cancer accounts for a quarter of all cancers and ranks as the second most common cancer in the world. In particular, triple negative breast cancer is aggressive and lacks targeted therapeutic options. Hence, new therapeutic targets need to be identified for personalised treatment strategies to improve patient outcomes.
openaire   +2 more sources

Fibroblast Growth Factor and Epidermal Growth Factor Receptors in Ligament Healing

Clinical Orthopaedics and Related Research, 1997
Although recent in vivo studies indicate that basic fibroblast growth factor hastens the healing and strength of the medical collateral ligament after injury, in vitro studies with epidermal growth factor and basic fibroblast growth factor have shown increased fibroblast proliferation with the exogenous administration of these growth factors.
Stephen H. Liu, Gerald A. M. Finerman, Joseph M. Lane, Vah Panossian   +3 more
openaire   +3 more sources

Fibroblast Growth Factors and Their Receptors in Hematopoiesis and Hematological Tumors

Journal of Hematotherapy & Stem Cell Research, 2002
Fibroblast growth factors (FGFs) belong to a family of pleiotropic heparin-binding growth factors. They exert multiple functions on various cell types of mesodermal and neuroectodermal origin, affecting cell proliferation, motility, survival, and differentiation.
MORONI E., DELL'ERA, Patrizia, RUSNATI, Marco, PRESTA, Marco   +3 more
openaire   +4 more sources

The ins and outs of fibroblast growth factor receptor signalling.

Clinical science, 2014
FGFR (fibroblast growth factor receptor) signalling plays critical roles in embryogensis, adult physiology, tissue repair and many pathologies. Of particular interest over recent years, it has been implicated in a wide range of cancers, and concerted ...
Stacey J. Coleman, Charo Bruce, A. Chioni, H. Kocher, R. Grose   +4 more
semanticscholar   +1 more source

Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2).

Developmental Biology, 1993
The gene for fibroblast growth factor receptor-2 (FGFR2) encodes two splice variants designated here as keratinocyte growth factor (KGFR) and bek. Their ligand-binding specificity is markedly different due to mutually exclusive alternative splicing.
A. Orr-Urtreger, M. Bedford, T. Burakova, E. Arman, Y. Zimmer, A. Yayon, D. Givol, P. Lonai   +7 more
semanticscholar   +1 more source