Construction and characterization of immunoliposomes targeting fibroblast growth factor receptor 3 [PDF]
AMB Express, 2019 Fibroblast growth factor receptor 3 (FGFR3) plays an important regulatory role in tumor cell proliferation and drug resistance. FGFR3 is often constitutively active in many tumors.
Zhong Zheng +8 more
doaj +6 more sources
Clinical features with anti fibroblast growth factor receptor 3 (FGFR3) antibody-related polyneuropathy: a retrospective study [PDF]
BMC Neurology, 2021 Background Despite its initial association with sensory neuropathies, anti-fibroblast growth factor receptor 3 (FGFR3) antibodies have been since reported with a broad range of neuropathies and clinical features.
Elanagan Nagarajan +3 more
doaj +4 more sources
Fibroblast growth factor receptor 3 in hepatocytes protects from toxin-induced liver injury and fibrosis [PDF]
iScience, 2021 Summary: The liver's remarkable regenerative capacity is orchestrated by several growth factors and cytokines. Fibroblast growth factor receptor 3 (Fgfr3) is frequently overexpressed in hepatocellular carcinoma and promotes cancer aggressiveness, whereas
Abbie E. Fearon +10 more
doaj +4 more sources
Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma [PDF]
BMC Urology, 2018 Background Recent studies suggest that FGFR3 is a potential therapeutic target in urothelial carcinoma (UC). The purpose of this study was to evaluate the rates and types of FGFR3 aberrations in patients with muscle-invasive UC who received radical ...
Young Saing Kim +4 more
doaj +6 more sources
Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes [PDF]
Journal of Animal Science and Biotechnology, 2012 Background Fibroblast growth factor receptor 3 (FGFR3) inhibits growth-plate chondrocyte proliferation and limits bone elongation. Gain-of-function FGFR3 mutations cause dwarfism, reduced telomerase activity and shorter telomeres in growth plate ...
Smith Logan B +2 more
doaj +8 more sources
Fibroblast Growth Factor Receptor 3 Amplified Metastatic Melanoma Treated With Erdafitinib. [PDF]
Cureus, 2020 The treatment of metastatic melanoma has changed dramatically in the last decade with the introduction of immunotherapy and targeted therapy. A futile disease in the past is now treated with various options, resulting in improvement in progression-free and overall survivals, along with improvement in the quality of life.
Sarkisian S +4 more
europepmc +5 more sources
Asn540Lys mutation in fibroblast growth factor receptor 3 and phenotype in hypochondroplasia [PDF]
Acta Paediatrica, 2000 Hypochondroplasia is characterized by a disproportionate short stature with rhizomelic shortening of the limbs. Amino acid substitutions Asn540Lys, Asn540Thr and Ile538Val in the fibroblast growth factor receptor 3 (FGFR3) are considered to cause hypochondroplasia.
Giedre Grigelioniené +6 more
openalex +4 more sources
FGFR3 (fibroblast growth factor receptor 3) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010 Review on FGFR3 (fibroblast growth factor receptor 3), with data on DNA, on the protein encoded, and where the gene is implicated.
Jacky Bonaventure
openalex +4 more sources
Canine fibroblast growth factor receptor 3 sequence is conserved across dogs of divergent skeletal size [PDF]
BMC Genetics, 2008 Background Fibroblast growth factor receptor 3 (FGFR3) is expressed in the growth plate of endochondral bones and serves as a negative regulator of linear bone elongation.
Grossman Deborah I +5 more
doaj +2 more sources
In vitro and in vivo characterization of Recifercept, a soluble fibroblast growth factor receptor 3, as treatment for achondroplasia. [PDF]
PLoS ONE, 2020 Achondroplasia is a rare genetic disorder caused by mutations in the Fibroblast Growth Factor receptor 3 (FGFR3). These mutations lead to aberrant increase of inhibitory signaling in proliferating chondrocytes at the growth plate.
Diogo Gonçalves +8 more
doaj +2 more sources