Results 1 to 10 of about 356,203 (328)

Construction and characterization of immunoliposomes targeting fibroblast growth factor receptor 3 [PDF]

AMB Express, 2019
Fibroblast growth factor receptor 3 (FGFR3) plays an important regulatory role in tumor cell proliferation and drug resistance. FGFR3 is often constitutively active in many tumors.
Zhong Zheng, Haotian Ji, Wenbo Zong, Qiuju Ran, Xinxin Wang, Xi Yang, Zhuo Zhao, Chengjun Yang, Yechen Xiao   +8 more
doaj   +6 more sources

Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma [PDF]

BMC Urology, 2018
Background Recent studies suggest that FGFR3 is a potential therapeutic target in urothelial carcinoma (UC). The purpose of this study was to evaluate the rates and types of FGFR3 aberrations in patients with muscle-invasive UC who received radical ...
Young Saing Kim, Kyung Kim, Ghee-Young Kwon, Su Jin Lee, Se Hoon Park   +4 more
doaj   +6 more sources

Fibroblast growth factor receptor 3 in hepatocytes protects from toxin-induced liver injury and fibrosis [PDF]

iScience, 2021
Summary: The liver's remarkable regenerative capacity is orchestrated by several growth factors and cytokines. Fibroblast growth factor receptor 3 (Fgfr3) is frequently overexpressed in hepatocellular carcinoma and promotes cancer aggressiveness, whereas
Abbie E. Fearon, Coenraad F. Slabber, Andrii Kuklin, Marc Bachofner, Luigi Tortola, Lea Pohlmeier, Sophia Pantasis, Thorsten Hornemann, Lin Chen, Manfred Kopf, Sabine Werner   +10 more
doaj   +4 more sources

Inter-laboratory comparison of a serum fibroblast growth factor receptor 3 (FGFR3) antibody test in sensory neuropathies [PDF]

Frontiers in Immunology
IntroductionAutoantibodies against fibroblast growth factor receptor 3 (FGFR3) have been suggested as a diagnostic marker in both sensory large and small fiber neuropathy.
Luise Appeltshauser, Christian P. Moritz, Christian P. Moritz, Lena Reinhardt, Luisa Kreß, Nurcan Üçeyler, François Lassablière, Anastasia Barcic, Sabine Seefried, Claudia Sommer, Yannick Tholance, Jean-Christophe Antoine, Jean-Philippe Camdessanché, Kathrin Doppler   +13 more
doaj   +4 more sources

Fibroblast Growth Factor Receptor 3 Amplified Metastatic Melanoma Treated With Erdafitinib. [PDF]

Cureus, 2020
The treatment of metastatic melanoma has changed dramatically in the last decade with the introduction of immunotherapy and targeted therapy. A futile disease in the past is now treated with various options, resulting in improvement in progression-free and overall survivals, along with improvement in the quality of life.
Sarkisian S, McIntosh A, Nair S, Shoushtari AN, Callahan M.   +4 more
europepmc   +5 more sources

Clinical features with anti fibroblast growth factor receptor 3 (FGFR3) antibody-related polyneuropathy: a retrospective study [PDF]

BMC Neurology, 2021
Background Despite its initial association with sensory neuropathies, anti-fibroblast growth factor receptor 3 (FGFR3) antibodies have been since reported with a broad range of neuropathies and clinical features.
Elanagan Nagarajan, Seung Ah Kang, Carmen Holmes, Raghav Govindarajan   +3 more
doaj   +2 more sources

Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes [PDF]

Journal of Animal Science and Biotechnology, 2012
Background Fibroblast growth factor receptor 3 (FGFR3) inhibits growth-plate chondrocyte proliferation and limits bone elongation. Gain-of-function FGFR3 mutations cause dwarfism, reduced telomerase activity and shorter telomeres in growth plate ...
Smith Logan B, Belanger Janelle M, Oberbauer Anita M   +2 more
doaj   +2 more sources

Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy [PDF]

Journal of Orthopaedic Translation
Background: Hypochondroplasia (HCH) is a prevalent form of dwarfism linked to mutations in the fibroblast growth factor receptor 3 (FGFR3) gene, causing missense alterations.
Jing Chen, Dan He, Chengrun Yuan, Na Li, Baohong Shi, Conway Niu, Jiangfei Yang, Liangkai Zheng, Lin Che, Ren Xu   +9 more
doaj   +2 more sources

Correction to: Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real world experience. [PDF]

Br J Cancer, 2022
Rose TL, Weir WH, Mayhew GM, Shibata Y, Eulitt P, Uronis JM, Zhou M, Nielsen M, Smith AB, Woods M, Hayward MC, Salazar AH, Milowsky MI, Wobker SE, McGinty K, Millburn MV, Eisner JR, Kim WY.   +17 more
europepmc   +3 more sources

Irinotecan Upregulates Fibroblast Growth Factor Receptor 3 Expression in Colorectal Cancer Cells, Which Mitigates Irinotecan-Induced Apoptosis [PDF]

Translational Oncology, 2017
BACKGROUND: Irinotecan (IRI) is an integral part of colorectal cancer (CRC) therapy, but response rates are unsatisfactory and resistance mechanisms are still insufficiently understood.
Zeynep N. Erdem, Stefanie Schwarz, Daniel Drev, Christine Heinzle, Andrea Reti, Petra Heffeter, Xenia Hudec, Klaus Holzmann, Bettina Grasl-Kraupp, Walter Berger, Michael Grusch, Brigitte Marian   +11 more
doaj   +2 more sources