Construction and characterization of immunoliposomes targeting fibroblast growth factor receptor 3 [PDF]
AMB Express, 2019 Fibroblast growth factor receptor 3 (FGFR3) plays an important regulatory role in tumor cell proliferation and drug resistance. FGFR3 is often constitutively active in many tumors.
Zhong Zheng +8 more
doaj +5 more sources
Fibroblast growth factor receptor 3 in hepatocytes protects from toxin-induced liver injury and fibrosis [PDF]
iScience, 2021 Summary: The liver's remarkable regenerative capacity is orchestrated by several growth factors and cytokines. Fibroblast growth factor receptor 3 (Fgfr3) is frequently overexpressed in hepatocellular carcinoma and promotes cancer aggressiveness, whereas
Abbie E. Fearon +10 more
doaj +2 more sources
Clinical features with anti fibroblast growth factor receptor 3 (FGFR3) antibody-related polyneuropathy: a retrospective study [PDF]
BMC Neurology, 2021 Background Despite its initial association with sensory neuropathies, anti-fibroblast growth factor receptor 3 (FGFR3) antibodies have been since reported with a broad range of neuropathies and clinical features.
Elanagan Nagarajan +3 more
doaj +2 more sources
Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma [PDF]
BMC Urology, 2018 Background Recent studies suggest that FGFR3 is a potential therapeutic target in urothelial carcinoma (UC). The purpose of this study was to evaluate the rates and types of FGFR3 aberrations in patients with muscle-invasive UC who received radical ...
Young Saing Kim +4 more
doaj +2 more sources
Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy [PDF]
Journal of Orthopaedic TranslationBackground: Hypochondroplasia (HCH) is a prevalent form of dwarfism linked to mutations in the fibroblast growth factor receptor 3 (FGFR3) gene, causing missense alterations.
Jing Chen +9 more
doaj +2 more sources
Inter-laboratory comparison of a serum fibroblast growth factor receptor 3 (FGFR3) antibody test in sensory neuropathies [PDF]
Frontiers in ImmunologyIntroductionAutoantibodies against fibroblast growth factor receptor 3 (FGFR3) have been suggested as a diagnostic marker in both sensory large and small fiber neuropathy.
Luise Appeltshauser +13 more
doaj +2 more sources
Tumor Biology, 2017 In the past decades, the oncogenic role of fibroblast growth factor receptor 2 has been demonstrated in a number of cancer types. However, studies have reported contradictory findings concerning the correlation between fibroblast growth factor receptor 2
Gang Liu +3 more
doaj +2 more sources
Fibroblast Growth Factor Receptor 3 Amplified Metastatic Melanoma Treated With Erdafitinib. [PDF]
Cureus, 2020 The treatment of metastatic melanoma has changed dramatically in the last decade with the introduction of immunotherapy and targeted therapy. A futile disease in the past is now treated with various options, resulting in improvement in progression-free and overall survivals, along with improvement in the quality of life.
Sarkisian S +4 more
europepmc +4 more sources
Irinotecan Upregulates Fibroblast Growth Factor Receptor 3 Expression in Colorectal Cancer Cells, Which Mitigates Irinotecan-Induced Apoptosis [PDF]
Translational Oncology, 2017 BACKGROUND: Irinotecan (IRI) is an integral part of colorectal cancer (CRC) therapy, but response rates are unsatisfactory and resistance mechanisms are still insufficiently understood.
Zeynep N. Erdem +11 more
doaj +2 more sources
Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody [PDF]
Disease Models & Mechanisms, 2016 Activating mutations in fibroblast growth factor receptor 3 (FGFR3) have been identified in multiple types of human cancer and in congenital birth defects.
Yongjun Yin +12 more
doaj +2 more sources