Results 211 to 220 of about 230,861 (252)

p73 and p63 regulate the expression of fibroblast growth factor receptor 3

Biochemical and Biophysical Research Communications, 2010
p53, p63 and p73 make a family of transcription factors that play a vital role in development and cancer. All p53 family members have more than one promoter producing Transactivating (TA) and Dominant Negative (DeltaN) isoforms and their mRNAs are subjected to extensive splicing at 3' end to produce multiple protein products. p53 is usually inactivated
SAYAN AE, D'ANGELO B, SAYAN BS, TUCCI P, CIMINI, Anna Maria, CERÙ MP, KNIGHT RA, MELINO G.   +7 more
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Fibroblast Growth Factor Receptor 3 (FGFR3) Expression in Malignant Lymphomas

Applied Immunohistochemistry & Molecular Morphology, 2008
Fibroblast growth factor receptor 3 (FGFR3) protein is aberrantly expressed in approximately 15% of cases of plasma cell myeloma as a result of t(4;14)(p16.3;q32), and FGFR3 expression in myeloma is associated with an adverse prognosis. Novel, recently developed therapeutic agents that target the FGFR3 pathway are currently in clinical trials for ...
Andrew, Larson, James R, Cook
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Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

Nature, 1994
Achondroplasia, the most common cause of chondrodysplasia in man (1 in 15,000 live births), is a condition of unknown origin characterized by short-limbed dwarfism and macrocephaly. More than 90% of cases are sporadic and there is an increased paternal age at the time of conception of affected individuals, suggesting that de novo mutations are of ...
F, Rousseau, J, Bonaventure, L, Legeai-Mallet, A, Pelet, J M, Rozet, P, Maroteaux, M, Le Merrer, A, Munnich   +7 more
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Fibroblast Growth Factor Receptor-3 as a Marker for Precartilaginous Stem Cells

Clinical Orthopaedics and Related Research, 1999
The epiphyseal organ contains two kinds of cartilage, articular and growth plate. Both enlarge during the growth phase of life. However, mitosis is not apparent in these tissues. In the current study, a search to trace the reservoirs of stem cells needed for the growth of these cartilages is done. A disorder in which the stem cells responsible for bone
D, Robinson, A, Hasharoni, N, Cohen, A, Yayon, R M, Moskowitz, Z, Nevo   +5 more
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Asn540Lys mutation in fibroblast growth factor receptor 3 and phenotype in hypochondroplasia

Acta Paediatrica, 2000
Hypochondroplasia is characterized by a disproportionate short stature with rhizomelic shortening of the limbs. Amino acid substitutions Asn540Lys, Asn540Thr and Ile538Val in the fibroblast growth factor receptor 3 (FGFR3) are considered to cause hypochondroplasia.
G, Grigelioniené, O, Eklöf, E, Laurencikas, B, Ollars, N T, Hertel, J P, Dumanski, L, Hagenäs   +6 more
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Generation of Monoclonal Antibody Targeting Fibroblast Growth Factor Receptor 3

Hybridoma, 2009
Fibroblast growth factor receptor 3 (FGFR3) is a member of the FGFR family of receptor tyrosine kinases, whose function has been implicated in diverse biological processes, including cell proliferation, differentiation, survival, and tumorigenesis. Deregulation of FGFR3 signaling has been implicated with human pathologies, including cancer.
Olena, Gorbenko, Galyna, Ovcharenko, Tetyana, Klymenko, Olexandr, Zhyvoloup, Nadia, Gaman, Darija, Volkova, Ivan, Gout, Valeriy, Filonenko   +7 more
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Reduced binding of FGF1 to mutant fibroblast growth factor receptor 3

Growth Factors, 2006
The activating mutation FGFR3-R248C in the D2-D3 linker region of fibroblast growth factor receptor 3 leads as germline mutation to the neonatal lethal syndrome thanatophoric dysplasia type I (TD1). As somatic mutation it has been found in cancer. We introduced into the murine FGFR3 the mutation R242C that is orthologoues to the human mutation R248C. A
Denis, Khnykin, Sjur, Olsnes
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Prevalence of Pro250Arg mutation of fibroblast growth factor receptor 3 in coronal craniosynostosis

The Lancet, 1997
The C749G (Pro250Arg) mutation in the gene for fibroblast growth factor receptor 3 (FGFR3) has been found in patients with various types of craniosynostosis. We aimed to find out the proportion of cases of apparently non-syndromic coronal craniosynostosis attributable to this mutation.We studied 26 patients with coronal craniosynostosis but no ...
D M, Moloney, S A, Wall, G J, Ashworth, M, Oldridge, I A, Glass, C A, Francomano, M, Muenke, A O, Wilkie   +7 more
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Molecular cloning and developmental expression of rat fibroblast growth factor receptor 3

Histochemistry and Cell Biology, 2001
Fibroblast growth factors (FGFs) are involved in the control of a variety of biological functions including regulation and differentiation of various cell types. Furthermore, they play important roles in the processes of regeneration, angiogenesis, and chemotaxis.
P, Claus, C, Grothe
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Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

Nature Genetics, 1996
Fibroblast growth factor receptor 3 (Fgfr3) is a tyrosine kinase receptor expressed in developing bone, cochlea, brain and spinal cord. Achondroplasia, the most common genetic form of dwarfism, is caused by mutations in FGFR3. Here we show that mice homozygous for a targeted disruption of Fgfr3 exhibit skeletal and inner ear defects.
J S, Colvin, B A, Bohne, G W, Harding, D G, McEwen, D M, Ornitz   +4 more
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