Results 291 to 300 of about 356,203 (328)

Immunohistochemical localization of growth factors fibroblast growth factor-1 and fibroblast growth factor-2 and receptors fibroblast growth factor receptor-2 and fibroblast growth factor receptor-3 in normal oral epithelium, epithelial dysplasias, and squamous cell carcinoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2002
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been identified in a variety of carcinomas, but there are few studies concerning their presence in oral cancers. The objective of this study was to determine whether FGF-1, FGF-2, and high affinity receptors FGFR2 and FGFR3 are present in the pathogenesis of oral epithelial dysplasias ...
Candice, Wakulich, Linda, Jackson-Boeters, Tom D, Daley, George P, Wysocki   +3 more
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Fibroblast Growth Factor Receptor 3 (FGFR3) Expression in Malignant Lymphomas

Applied Immunohistochemistry & Molecular Morphology, 2008
Fibroblast growth factor receptor 3 (FGFR3) protein is aberrantly expressed in approximately 15% of cases of plasma cell myeloma as a result of t(4;14)(p16.3;q32), and FGFR3 expression in myeloma is associated with an adverse prognosis. Novel, recently developed therapeutic agents that target the FGFR3 pathway are currently in clinical trials for ...
Andrew, Larson, James R, Cook
openaire   +2 more sources

Generation of Monoclonal Antibody Targeting Fibroblast Growth Factor Receptor 3

Hybridoma, 2009
Fibroblast growth factor receptor 3 (FGFR3) is a member of the FGFR family of receptor tyrosine kinases, whose function has been implicated in diverse biological processes, including cell proliferation, differentiation, survival, and tumorigenesis. Deregulation of FGFR3 signaling has been implicated with human pathologies, including cancer.
Olena, Gorbenko, Galyna, Ovcharenko, Tetyana, Klymenko, Olexandr, Zhyvoloup, Nadia, Gaman, Darija, Volkova, Ivan, Gout, Valeriy, Filonenko   +7 more
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Expression of fibroblast growth factor receptor 3 by fibroblast growth factor 2 in cultured chick embryo chondrocytes

Cell Biology International, 2005
Although fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor 3 (FGFR3) both inhibit longitudinal bone growth, little is known about the relationship between FGF2 and FGFR3. Accordingly, the current study examined the expression of FGFR3 mRNA after the administration of FGF2 using cultured chondrocytes from day 17 chick embryos to ...
Jo-Young, Suh, Young-Sam, Kim, Jin-Woo, Park, Jong-Kyung, Sonn, Woo-Taek, Kim   +4 more
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Mutations of the Fibroblast Growth Factor Receptor-3 Gene in Achondroplasia

Hormone Research, 1996
Achondroplasia (ACH), the most common cause of chondrodysplasia in man (1 in 15,000 live births), is an autosomal dominant condition of unknown origin characterized by short-limbed dwarfism and macrocephaly. Recently, a gene for ACH has been mapped to chromosome 4p16.3.
F, Rousseau, J, Bonaventure, L, Legeai-Mallet, A, Pelet, J M, Rozet, P, Maroteaux, M, Le Merrer, A, Munnich   +7 more
openaire   +2 more sources

Reduced binding of FGF1 to mutant fibroblast growth factor receptor 3

Growth Factors, 2006
The activating mutation FGFR3-R248C in the D2-D3 linker region of fibroblast growth factor receptor 3 leads as germline mutation to the neonatal lethal syndrome thanatophoric dysplasia type I (TD1). As somatic mutation it has been found in cancer. We introduced into the murine FGFR3 the mutation R242C that is orthologoues to the human mutation R248C. A
Denis, Khnykin, Sjur, Olsnes
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Fibroblast growth factor receptor 3 and the human chondrodysplasias

Current Opinion in Pediatrics, 1997
Heterozygous mutations of the gene encoding the fibroblast growth factor receptor 3 (FGFR3) have been found in persons with achondroplasia, thanatophoric dysplasia, and hypochondroplasia. They exhibit considerable genetic homogeneity, and specific mutations strongly correlate with the clinical severity of disease.
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Motor deficits in fibroblast growth factor receptor-3 null mutant mice

Behavioural Pharmacology, 2001
Fibroblast growth factor receptor-3 (FGFR-3) regulates aspects of bone development. Mutations in the FGFR-3 gene (Fgfr3) in humans and mice produce vertebral abnormalities and bone deformities. The present study evaluated the behavioural concomitants of the Fgfr3-/- mutation.
M P, McDonald, K M, Miller, C, Li, C, Deng, J N, Crawley   +4 more
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p73 and p63 regulate the expression of fibroblast growth factor receptor 3

Biochemical and Biophysical Research Communications, 2010
p53, p63 and p73 make a family of transcription factors that play a vital role in development and cancer. All p53 family members have more than one promoter producing Transactivating (TA) and Dominant Negative (DeltaN) isoforms and their mRNAs are subjected to extensive splicing at 3' end to produce multiple protein products. p53 is usually inactivated
SAYAN AE, D'ANGELO B, SAYAN BS, TUCCI P, CIMINI, Anna Maria, CERÙ MP, KNIGHT RA, MELINO G.   +7 more
openaire   +7 more sources

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

Nature Genetics, 1996
Fibroblast growth factor receptor 3 (Fgfr3) is a tyrosine kinase receptor expressed in developing bone, cochlea, brain and spinal cord. Achondroplasia, the most common genetic form of dwarfism, is caused by mutations in FGFR3. Here we show that mice homozygous for a targeted disruption of Fgfr3 exhibit skeletal and inner ear defects.
J S, Colvin, B A, Bohne, G W, Harding, D G, McEwen, D M, Ornitz   +4 more
openaire   +2 more sources