Results 51 to 60 of about 356,203 (328)

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder [PDF]

, 2011
The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a ‘driver’ of UCC, we targeted the expression of mutated
Ahmad, I., Foth, M., Iwata, T., Leung, H.Y., Morris, C.-A., Sansom, O.J., Singh, L.B., Taketo, M.M., Wu, X.-R.   +8 more
core   +3 more sources

Canine fibroblast growth factor receptor 3 sequence is conserved across dogs of divergent skeletal size

BMC Genetics, 2008
Background Fibroblast growth factor receptor 3 (FGFR3) is expressed in the growth plate of endochondral bones and serves as a negative regulator of linear bone elongation.
Grossman Deborah I, Young Amy E, Bannasch Danika L, Smith Logan B, Belanger Janelle M, Oberbauer Anita M   +5 more
doaj   +1 more source

Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours [PDF]

Oncogene, 2001
Mutations in FGFR3 have been identified in several tumour types including bladder carcinoma, cervical carcinoma, and multiple myeloma. In bladder carcinoma, we recently identified FGFR3 mutations in 41% of tumours, making this the most frequently mutated putative oncogene identified in bladder cancer to date.
K, Sibley, P, Stern, M A, Knowles
openaire   +2 more sources

The Antimicrobial Peptide Human β-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR/JAK2/STAT3 Signaling Pathway

Frontiers in Immunology, 2021
In addition to its antimicrobial activity, the skin-derived antimicrobial peptide human β-defensin-3 (hBD-3) promotes keratinocyte proliferation and migration to initiate the wound healing process; however, its effects on fibroblasts, which are the major
Miho Takahashi, Miho Takahashi, Yoshie Umehara, Hainan Yue, Hainan Yue, Juan Valentin Trujillo-Paez, Ge Peng, Ge Peng, Hai Le Thanh Nguyen, Hai Le Thanh Nguyen, Risa Ikutama, Risa Ikutama, Ko Okumura, Hideoki Ogawa, Hideoki Ogawa, Shigaku Ikeda, Shigaku Ikeda, François Niyonsaba, François Niyonsaba   +18 more
doaj   +1 more source

Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model [PDF]

, 2011
AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2].
Anderson, Beenken, Bochukova, Burgar, Celli, Cohen, De Moerlooze, Duan, Duchesne, Ezzat, Fairbanks, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hanneken, Ibrahimi, Jang, Jang, Jang, John K. Heath, Jones, Kawano, Klein, Kuro-o, Lee M. Wheldon, Lewis, Maquat, McKeehan, Mendell, Meyers, Miki, Mohammad K. Hajihosseini, Muhlemann, Naila Khodabukus, Naski, Nelson, Oldridge, Peters, Polanska, Ricol, Saito, Sekine, Slaney, Smith, Susannah J. Patey, Takaishi, Tanimoto, Terada, Terence G. Smith, Tsang, Tsukuno, Werner, Wheldon, Wilkie, Yamaguchi, Zhang   +57 more
core   +3 more sources

FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation [PDF]

, 2009
Fibroblast growth factor (FGF) signaling controls a vast array of biological processes including cell differentiation and migration, wound healing and malignancy.
Kadam, Snehalata, McMahon, Amy, Stathopoulos, Angelike, Tzou, Phoebe   +3 more
core   +4 more sources

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1 [PDF]

, 2018
Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis is ...
A Clayton, A Desmouliere, A Holmes, A Yabuki, AA Eddy, AA Eddy, AC Sanchez-Lara, BL Aken, C Grupp, C. P. D. Wheeler-Jones, CH Heldin, CL Marino, E Honda, E Van Obberghen-Schilling, F Strutz, F Strutz, F Syeda, GR Grotendorst, H. M. Syme, HP Rodemann, J Ivaska, J Lu, J. Elliott, J. S. Lawson, JL Mumaw, JS Lawson, K Sawashima, KG McCullagh, KJ Kelynack, LC Penning, M Prunotto, M Zeisberg, MA Venkatachalam, MJ Ryan, MK Phanish, ML Sequeira Lopez, P Boor, P Sysa, PC Bartlett, Q Chai, RA Ignotz, S Chakrabarti, S Meran, S Moll, S Neelisetty, SC Chen, SL Lin, SP DiBartola, SW Smith, T Akamatsu, TA Wynn, V Dugina, VS Lebleu, W Bloom, WA Border, X Pan, XM Meng, Y Hosokawa, Y Liu   +58 more
core   +2 more sources

Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. [PDF]

PLoS ONE, 2012
Fibroblast Growth Factor receptor (FGFR) activity plays crucial roles in tumor growth and patient survival. However, FGF (Fibroblast Growth Factor) signaling as a target for cancer therapy has been under-investigated compared to other receptor tyrosine ...
Frédéric Larrieu-Lahargue, Alana L Welm, Marion Bouchecareilh, Kari Alitalo, Dean Y Li, Andreas Bikfalvi, Patrick Auguste   +6 more
doaj   +1 more source

A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor. [PDF]

, 2013
Basic fibroblast growth factor (bFGF) is a protein that plays a crucial role in diverse cellular functions, from wound healing to bone regeneration.
Decker, Caitlin G, Kim, Sung-Hye, Loo, Joseph A, Maynard, Heather D, Nguyen, Thi H, Wong, Darice Y   +5 more
core   +1 more source

Fibroblast Growth Factor Receptor 3 (FGFR3) Gene Amplification in Patients with Urothelial Carcinoma of the Urinary Bladder

The Iraqi Journal of Medical Sciences, 2021
Background: The fibroblast growth factor receptors (FGFRs) family includes five tyrosine kinase receptors, which play an important role in many cellular mechanisms including proliferation, migration and survival.
Mohsin Al-Marashi, Ban Qasim
doaj   +1 more source