The effects of coating culture dishes with collagen on fibroblast cell shape and swirling pattern formation [PDF]
arXiv, 2019 Motile human-skin fibroblasts form macroscopic swirling patterns when grown to confluence on a culture dish. In this paper, we investigate the effect of coating the culture-dish surface with collagen on the resulting pattern, using human-skin fibroblast NB1RGB cells as the model system.
arxiv
An Information-Theoretic Framework for Identifying Age-Related Genes Using Human Dermal Fibroblast Transcriptome Data [PDF]
arXiv, 2021 Investigation of age-related genes is of great importance for multiple purposes, for instance, improving our understanding of the mechanism of ageing, increasing life expectancy, age prediction, and other healthcare applications. In his work, starting with a set of 27,142 genes, we develop an information-theoretic framework for identifying genes that ...
arxiv
Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION. [PDF]
, 2016 The relevance of mitochondrial phosphate carrier (PiC), encoded by SLC25A3, in bioenergetics is well accepted. However, little is known about the mechanisms mediating the cellular impairments induced by pathological SLC25A3 variants.
Acoba, Michelle G. +9 more
core +2 more sources
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Single-Cell RNA Sequencing Reveals CXCLs Enriched Fibroblasts Within Odontogenic Keratocysts
Journal of Inflammation Research, 2021 Qi-Wen Man,1,2,* Rui-Fang Li,1,* Su-Ran Li,1 Jing Wang,1 Lin-Lin Bu,1,2 Yi Zhao,3 Bing Liu1,2 1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School &
Man QW +6 more
doaj
An Modified Primary Culture Method of Breast Cancer-associated Fibroblasts
Zhongliu Fangzhi Yanjiu, 2018 Objective To establish a rapid and high efficient method of primary culture of BCAFs by improving primary culture methods of common breast cancer-associated fibroblasts (BCAFs).
LI Zhiyong, BAI Xue, CAI Huiyun
doaj +1 more source
The connexin mimetic peptide Gap27 and Cx43-Knockdown reveal differential roles for Connexin43 in wound closure events in skin model systems [PDF]
, 2018 In the epidermis, remodelling of Connexin43 is a key event in wound closure. However, controversy between the role of connexin channel and non-channel functions exist.
Annette Graham +7 more
core +4 more sources
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis
Frontiers in Oncology, 2018 Solid tumors are characterized by an abnormal stroma that contributes to the development of biomechanical abnormalities in the tumor microenvironment. In particular, these abnormalities include an increase in matrix stiffness and an accumulation of solid
Maria Kalli +1 more
doaj +1 more source
Communication shapes sensory response in multicellular networks [PDF]
, 2015 Collective sensing by interacting cells is observed in a variety of biological systems, and yet a quantitative understanding of how sensory information is collectively encoded is lacking. Here we investigate the ATP-induced calcium dynamics of monolayers of fibroblast cells that communicate via gap junctions.
arxiv +1 more source