Results 101 to 110 of about 747,670 (306)

Phage Ligands for Identification of Mesenchymal-Like Breast Cancer Cells and Cancer-Associated Fibroblasts

Frontiers in Oncology, 2018
Epithelial to mesenchymal transition (EMT) is believed to be crucial for primary tumors to escape their original residence and invade and metastasize. To properly define EMT, there is a need for ligands that can identify this phenomenon in tumor tissue ...
Kelvin M. Jones, Balasubramanyam Karanam, Jacqueline Jones-Triche, Maninder Sandey, Henry J. Henderson, Rajeev S. Samant, Samuel Temesgen, Clayton Yates, Deepa Bedi   +8 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Toll-like receptor 4 activation attenuates profibrotic response in control lung fibroblasts but not in fibroblasts from patients with IPF. [PDF]

, 2017
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with a median survival of 3 yr. IPF deteriorates upon viral or bacterial lung infection although pulmonary infection (pneumonia) in healthy lungs rarely induces fibrosis.
Ebener, Simone, Wotzkow Alvarez, Carlos, Crestani, Bruno, Sandra Barnowski, Marti, Thomas, Bruno Crestani, Barnowski, Sandra, Blank, Fabian, Simone Ebener, Thomas Geiser, Geiser, Thomas, Funke, Manuela, Manuela Funke, Thomas M. Marti, Schmid, Ralph, Ralph A. Schmid, Lopez-Rodriguez, Elena, Carlos Wotzkow, Elena Lopez-Rodriguez, Fabian Blank, Wotzkow C, Barnowski S, Marti TM, Blank F, Ebener S, Geiser T, Crestani B, Lopez-Rodriguez E, Schmid RA, Funke M   +29 more
core   +1 more source

Inhibition of microRNA-139-5p Improves Fibroblasts Viability and Enhances Wound Repair in Diabetic Rats Through AP-1 (c-Fos/c-Jun)

Diabetes, Metabolic Syndrome and Obesity
Jiake Mo,1,2,* Jiaqi Zhang,1,2,* Xubiao Meng,3 Fang Wang,1,2 Weian Tang,1,2 Ying Liu,1,2 Lanfang Fu,3 Fang Liang,4 Zhaohui Mo1,2 1Department of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, People’s ...
Mo J, Zhang J, Meng X, Wang F, Tang W, Liu Y, Fu L, Liang F, Mo Z   +8 more
doaj  

Inhibition of BTK and SYK attenuates Porphyromonas gingivalis -induced activation of the pyroptosis pathway and inflammation in host cells

Journal of Oral Microbiology
Background Periodontitisis a chronic inflammatory disease of the oral cavity, primarily driven by periodontopathogens such as Porphyromonas gingivalis (Pg)."Objective We investigated the therapeutic potential of BTK and SYK inhibitors on the pathological
Alicja Plonczynska, Aureliusz Schuster, Dominika M. Drapala, Tomasz Kaczmarzyk, Magdalena Nowak, Jan Potempa, Aleksander M. Grabiec, Maja Sochalska   +7 more
doaj   +1 more source

Expression of Programmed Death-Ligand 1 by Human Colonic CD90+ Stromal Cells Differs Between Ulcerative Colitis and Crohn’s Disease and Determines Their Capacity to Suppress Th1 Cells

Frontiers in Immunology, 2018
Background and AimsThe role of programmed cell death protein 1 (PD-1) and its ligands in the dysregulation of T helper immune responses observed in the inflammatory bowel disease (IBD) is unclear. Recently, a novel concept emerged that CD90+ colonic (myo)
Ellen J. Beswick, Carl Grim, Abinav Singh, Jose E. Aguirre, Marissa Tafoya, Suimin Qiu, Gerhard Rogler, Rohini McKee, Von Samedi, Thomas Y. Ma, Victor E. Reyes, Victor E. Reyes, Don W. Powell, Irina V. Pinchuk, Irina V. Pinchuk   +14 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source