Results 71 to 80 of about 988,166 (377)

HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2 [PDF]

, 2016
Hepatitis C virus (HCV) infection is a leading cause of liver fibrosis, especially in developing countries. The process is characterized by the excess accumulation of ECM that may lead, over time, to hepatic cirrhosis, liver failure and also to ...
ANTONELLI, Guido, CARDI, ANTONIO, CIRONE, Mara, FAGGIONI, Alberto, GRANATO, Marisa, MARCHESE, Cinzia, Rizzello, C, TORRISI, Maria Rosaria, Valia, S, Vescarelli, Enrica, Zompetta, C   +10 more
core   +1 more source

Phosphorylation of fibroblast myosin [PDF]

FEBS Letters, 1977
1. Introduction The fact that myosin might be phosphorylated has been known for more than a decade [l] . However, only recently have special kinases been described, in striated muscle [2] and in platelets [3] , which catalyze the phosphorylation of one of the light-chains of myosin.
Avraham Oplatka, Andras Muhlrad
openaire   +3 more sources

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Cancer associated fibroblasts: the architects of stroma remodelling [PDF]

, 2018
Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast amount of soluble factors, ECM components and extracellular vesicles. While in physiological conditions this makes fibroblasts master regulators of tissue homeostasis and ...
Acerbi, Aebersold, Albrengues, Alitalo, Asahara, Ausprunk, Azzi, Bagordakis, Baluk, Bandura, Barth, Bekker-Jensen, BelAiba, Bendall, Bergers, Bochet, Boeck, Boelens, Bonuccelli, Brew, Bronisz, Bronzert, Byron, Calvo, Castermans, Chang, Chaurand, Chen, Chevrier, Chiavarina, Chomarat, Chong, Cirri, Cleaver, Cline, Consortium, Cox, Debinski, di Tomaso, Direkze, Dranoff, Duda, Dudley, Edwards, Egeblad, Erez, Fan, Feig, Fiaschi, Fukumura, Gabbiani, Gabbiani, Gaggioli, Gascard, Gauthier, Giannoni, Gilkes, Gilkes, Groessl, Guido, Hanahan, Hanahan, Hanley, Hawsawi, Hernandez-Fernaud, Hillen, Hirata, Holash, Holmberg, Holmberg, Hoshida, Hsu, Jacob, Kalluri, Kalluri, Kalluri, Karpanen, Kim, Koczorowska, Kojima, Konerding, Kotake-Nara, Kuchnio, Kulak, Labernadie, Lamond, Lavin, Lavin, Leu, Liao, Lohr, Lu, Madsen, Mandriota, Maris, Marsh, Martinez-Outschoorn, Martinez-Outschoorn, Mayorca-Guiliani, McDonnell, McIntyre, Mercier, Murphy, Naba, Naba, Naba, Naba, Naba, Nabet, Nummer, Ogle, Ohlund, Ong, Orimo, Ozbek, Ozdemir, Padera, Papetti, Pavlides, Perryman, Petersen, Pickup, Pietras, Porter, Pouyssegur, Radisky, Rashid, Rechavi, Reid, Reymond, Rhim, Roach, Ronnov-Jessen, Ross, Rost, Rozario, Santi, Santos, Sanz-Moreno, Scheltema, Schoppmann, Serini, Shao, Sharma, Shetty, Shimoda, Shintani, Slany, Soon, Sousa, Spaeth, Speiser, Straussman, Strutz, Sugimoto, Szklarczyk, Tang, Tape, Tape, Torres, Toullec, Tremblay, Trimboli, Trimmer, Ullah, Vennin, Wang, Warren, Wever, Whatcott, Whitaker-Menezes, Wickstrom, Yang, Yang, Yu, Zaman, Zeisberg, Zhang, Zhao   +178 more
core   +1 more source

Synovial fibroblasts in 2017 [PDF]

RMD Open, 2017
Stromal cells like synovial fibroblasts gained great interest over the years, since it has become clear that they strongly influence their environment and neighbouring cells. The current review describes the role of synovial fibroblasts as cells of the innate immune system and expands on their involvement in inflammation and cartilage destruction in ...
openaire   +4 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Myofibroblasts: Functions, evolution, origins, and the role in disease

SRM Journal of Research in Dental Sciences, 2015
Fibroblasts are ubiquitous mesenchymal cells, normally present in the stroma of many tissues of the body. They exhibit spindle shape morphology. There is phenotypic heterogeneity among fibroblasts.
Rekha Bhaskar Chaudhari
doaj   +1 more source

GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]

, 2013
Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Andras Dinnyes, Csilla Nemes, Eszter Varga, Jalving M., Melinda K. Pirity, Nuttha Klincumhom, Zsuzsanna Polgar   +6 more
core   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Remodelling of the fibre-aggregate structure of collagen gels by cancer-associated fibroblasts: a time-resolved grey-tone image analysis based on stochastic modelling [PDF]

arXiv, 2022
In solid tumors, cells constantly interact with the surrounding extracellular matrix. In particular cancer-associated fibroblasts modulate the architecture of the matrix by exerting forces and contracting collagen fibres, creating paths that facilitate cancer cell migration.
arxiv