Results 41 to 50 of about 14,512 (220)

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

A Clinical Study of Decellularized Tissue Engineering Hyaline Cartilage Graft (dLhCG) for Articular Cartilage Repair

Advanced Science, EarlyView.
ABSTRACT Current clinical approaches for knee cartilage repair are often limited by hypertrophy and fibrosis in the regenerated tissues. A decellularized tissue‐engineered hyaline cartilage graft (dLhCG), composed of a type II collagen‐based extracellular matrix, has been developed to overcome this limitation.
Zhen Zhang, Gong Cheng, Wenyong Fei, Qiuzhen Liang, Liang Zhang, Kegui Liu, Jihang Dai, Bo Cong, Xu Hu, Zhonglian Wu, Jialu Zhang, Jinlan Cui, Hang Yao, Dong‐An Wang, Jingcheng Wang, Tao Sun, Jiang Zheng   +16 more
wiley   +1 more source

Meniscal repair by fibrocartilage in the dog:Characterization of the repair tissue and the role of vascularity

, 1996
Lesions in the avascular part of 20 canine menisci were repaired by implantation of a porous polyurethane. Seven menisci were not repaired and served as controls. The repair tissue was characterized by biochemical and immunological analysis.
Nielsen, HKL, Veth, RPH, Pennings, AJ, Jansen, HWB, deGroot, JH, Kuijer, R   +5 more
core   +2 more sources

Influence of interleukin-1 beta and hyaluronan on proteoglycan release from equine navicular hyaline cartilage and fibrocartilage

, 2000
Proteoglycan (PG) release, in response to recombinant human interleukin-1β (rh-IL-1β), was measured in cartilage explants obtained from the equine distal sesamoid bone (navicular bone).
Frean, S.P., Lees, P., May, S.A., Gettinby, G.   +3 more
core   +3 more sources

SR-FTIR as a tool for quantitative mapping of the content and distribution of extracellular matrix in decellularized book-shape bioscaffolds

BMC Musculoskeletal Disorders, 2018
Background To evaluate synchrotron radiation-based Fourier transform infrared microspectroscopy (SR-FTIR) as a tool for quantitative mapping of the content and distribution of the extracellular matrix in decellularized fibrocartilage bioscaffolds, and to
Yongchun Zhou, Can Chen, Zhu Guo, Shanshan Xie, Jianzhong Hu, Hongbin Lu   +5 more
doaj   +1 more source

Evolution and mechanistic insights of platelet-derived products in temporomandibular joint regeneration

Frontiers in Cell and Developmental Biology
Temporomandibular disorders (TMDs) and end-stage osteoarthritis are among the most common disabling diseases of the oral and maxillofacial region. Due to its unique fibrocartilaginous structure and limited vascularization, the temporomandibular joint ...
Cong Lin, Yutong Jin, Dan Li, Quanquan Yang, Tingyao Chen, Quan Chen, Mubin Zhang, Zhangbiao Long, Dongdong Fang   +8 more
doaj   +1 more source

Radioulnar joint reconstruction: a novel surgical technique and biomechanical assessment for chronic instability

Journal of Experimental Orthopaedics, 2020
Purpose This study aims to describe and biomechanically evaluate a novel technique using a strip of the flexor carpi ulnaris tendon for distal radioulnar joint reconstruction.
Gustavo Pacheco Martins Ferreira, Marcella Rodrigues Costa Simões, Haroldo Oliveira de Freitas Junior, Ubiratan Brum de Castro, Robinson Esteves Pires, Marco Antonio Percope de Andrade   +5 more
doaj   +1 more source

Liquid‐Responsive Shape‐Memory Nanofiber‐Reinforced Scaffolds for Cartilage Repair

Advanced Science, EarlyView.
A liquid‐responsive shape‐memory, nanofiber‐reinforced QCG scaffold combines conformal defect filling, an aligned architecture that is structurally permissive for endogenous cell infiltration, and sustained KGN release. This integrated design enhances BMSC viability, migratory activity, and chondrogenic differentiation and promotes hyaline cartilage ...
Jiyang Zeng, Wei Li, Yawei Li, Zhiming Tu, Hong Ma, Yuliang Dai, Zhaoling Ma, Tao Yuan, Bing Wang   +8 more
wiley   +1 more source

siRNA Treatment Enhances Collagen Fiber Formation in Tissue-Engineered Meniscus via Transient Inhibition of Aggrecan Production

Bioengineering
The complex collagen network of the native meniscus and the gradient of the density and alignment of this network through the meniscal enthesis is essential for the proper mechanical function of these tissues.
Serafina G. Lopez, Lara A. Estroff, Lawrence J. Bonassar   +2 more
doaj   +1 more source