Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage [PDF]
, 2009 We report a novel technology for the rapid healing of large osseous and chondral defects, based upon the genetic modification of autologous skeletal muscle and fat grafts.
A Walsh +15 more
core +4 more sources
Fibrodysplasia ossificans progressiva in Hong Kong—A case report series
Frontiers in Pediatrics, 2023 Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare condition. The diagnosis could be challenging due to its rarity and non-specific presenting symptoms.
Joshua Chun Ki Chan +10 more
doaj +1 more source
From variome to phenome : pathogenesis, diagnosis and management of ectopic mineralization disorders [PDF]
, 2015 Ectopic mineralization - inappropriate biomineralization in soft tissues - is a frequent finding in physiological aging processes and several common disorders, which can be associated with significant morbidity and mortality.
De Vilder, eva, Vanakker, Olivier
core +2 more sources
When Limb Surgery Has Become the Only Life-Saving Therapy in FOP: A Case Report and Systematic Review of the Literature [PDF]
, 2020 Fibrodysplasia ossificans progressiva (FOP) is a rare disease in which heterotopic ossification (HO) is formed in muscles, tendons and ligaments. Traumatic events, including surgery, are discouraged as this is known to trigger a flare-up with risk of ...
Botman, Esmée +20 more
core +2 more sources
Regenerative Therapy, 2019 The demand for development of new drugs remains on the upward trend because of the large number of patients suffering from intractable diseases for which effective treatment has not been established yet.
Taiki Nakajima, Makoto Ikeya
doaj +1 more source
New Spontaneous Model of Fibrodysplasia Ossificans Progressiva [PDF]
, 2008 We report the first known example of spontaneous, naturally occurring fibrodysplasia ossificans progressiva (FOP) in a mammal. The Southeast Asian mouse deer of the genus _Tragulus_ (Artiodactyla: Tragulidae) have an osseous sheath covering the lower ...
Bruce Rothschild +2 more
core +1 more source
Fibrodyslasia (Myositis) ossificans progressiva- A case report [PDF]
, 2016 We are presenting a case report of an 18yr old kenyan girl with big toe/ thumb anomalies and a 3 year history of heterotopic ossification of the temporo-mandibular joints, cervical spine, shoulders, elbows, lumbar spine and abdominal wall.
Mead, TC, Muteti, EN
core +2 more sources
Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1339-1351, May 2026.Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang +5 more
wiley +1 more source
Recent Topics in Fibrodysplasia Ossificans Progressiva [PDF]
Endocrinology and Metabolism, 2018 Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease that is characterized by the formation of heterotopic bone tissues in soft tissues, such as skeletal muscle, ligament, and tendon.
Takenobu Katagiri +3 more
doaj +1 more source
KoVariome: Korean National Standard Reference Variome database of whole genomes with comprehensive SNV, indel, CNV, and SV analyses [PDF]
, 2018 High-coverage whole-genome sequencing data of a single ethnicity can provide a useful catalogue of population-specific genetic variations, and provides a critical resource that can be used to more accurately identify pathogenic genetic variants.
A McKenna +59 more
core +2 more sources