Results 61 to 70 of about 2,003 (162)
Rheumatology &Autoimmunity, Volume 5, Issue 1, Page 28-36, March 2025.Fibrodysplasia ossificans progressiva, a rare genetic disorder caused by ACVR1 mutations, leads to soft tissue ossification. Recent advancements, including food and drug administration‐approved palovarotene, show promise despite safety concerns. Therapies like tofacitinib and imatinib demonstrate potential, but larger, controlled trials are essential ...
Muhammad Ikrama +6 more
wiley +1 more source
Advanced Science, Volume 12, Issue 8, February 24, 2025.ECSIT‐X4 is the predominant cardiac isoform of ECSIT, encoded by the Ecsit‐X4 transcript variant in adult cardiomyocytes. The splicing junction of exon 9 generates the mouse Ecsit‐X4 isoform, resulting in a recognizable C‐terminal sequence. It is shown that ECSIT‐X4 interacts with STAT3, enhancing the activity of complex I, thereby promoting ...
Xia Lu +13 more
wiley +1 more source
Fibrodysplasia ossificans progressiva-like in a cat
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2012 Fibrodysplasia ossificans progressiva-like (FOP-like) was diagnosed in a young Brazilian cat presenting progressive lameness, pain upon manipulation and inability to extend the hind limbs.
L.Z. Crivelenti +3 more
doaj +1 more source
Fibrodysplasia Ossificans Progressiva: Clinical and Genetic Aspects
Orphanet Journal of Rare Diseases, 2011 Fibrodysplasia ossificans progressiva (FOP) is a severely disabling heritable disorder of connective tissue characterized by congenital malformations of the great toes and progressive heterotopic ossification that forms qualitatively normal bone in ...
Pignolo Robert J +2 more
doaj +1 more source
Fibrodysplasia Ossificans Progressiva in an Adult Indian Male
Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2014 Following its first description by Guy Patin in 1692 as a disease that turned a woman into wood, Fibrodysplasia Ossificans Progressiva has maintained its low profile that too mainly in textbooks and rarely does one encounter a live walking individual ...
Rachit Harjai, Sushil Ghanshyam Kachewar
doaj
Arquivos de Neuro-Psiquiatria, 2005 Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by postnatal progressive heterotopic ossification of the connective tissue and congenital malformation of the big toes. We report on a nine-year-old girl with
Andre Leite Gonçalves +4 more
doaj +1 more source
Fibrodysplasia ossificans progressiva [PDF]
The Indian Journal of Pediatrics, 1994 S, Ganguly +3 more
openaire +3 more sources
The role of miRNAs as biomarkers in heterotopic ossification
EFORT Open ReviewsFibrodysplasia ossificans progressiva and progressive osseous heteroplasia are genetic forms of heterotopic ossification (HO). Fibrodysplasia ossificans progressiva is caused by ACVR1 gene mutations, while progressive osseous heteroplasia is caused by ...
Chen Xie +5 more
doaj +1 more source
The Fibrodysplasia Ossificans Progressiva and Bone Scintigraphy
Swiss Journal of Radiology and Nuclear MedicineFibrodysplasia ossificans progressiva (FOP) is an exceptionally rare autosomal dominant condition characterized by malformations of the big toes and progressive extra-skeletal ossifications in distinct anatomical patterns.
Sofia CHKIKAR +2 more
doaj +1 more source
Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva
Life Science AllianceOxidative phosphorylation plays a pivotal role in heterotopic ossification associated with fibrodysplasia ossificans progressiva, underscoring its potential as a significant therapeutic target.
Liping Sun +10 more
doaj +1 more source