Results 1 to 10 of about 5,020 (198)
ACVR1 Function in Health and Disease [PDF]
Cells, 2019 Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system
Francesc Ventura +2 more
exaly +9 more sources
Biomedicines, 2021 Activin receptor-like kinase 2 (ALK2), also known as Activin A receptor type 1 (ACVR1), is a transmembrane kinase receptor for members of the transforming growth factor-β family.
Takenobu Katagiri +2 more
exaly +4 more sources
Gut MicrobesHelicobacter pylori (H. pylori) infection plays a pivotal role in gastric carcinogenesis through inflammation-related mechanisms. Activin A receptor type I (ACVR1), known for encoding the type I receptor for bone morphogenetic proteins (BMPs), has been ...
Cong He, Xidong Wu, Xiao Fei
exaly +4 more sources
Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1 [PDF]
The Journal of Clinical Investigation, 2022 Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder whose most debilitating pathology is progressive and cumulative heterotopic ossification (HO) of skeletal muscles, ligaments, tendons, and fascia.
Senem Aykul +20 more
doaj +3 more sources
The role of the 3'UTR region in the regulation of the ACVR1/Alk-2 gene expression. [PDF]
PLoS ONE, 2012 BACKGROUND: The ACVR1/Alk-2 gene, encoding a BMP type I receptor, is mutated in Fibrodysplasia Ossificans Progressiva, a severe form of heterotopic ossification. Regulation of ACVR1/Alk-2 expression, still poorly understood, is likely to be controlled by
Marzia Mura +4 more
doaj +2 more sources
lncRNA-5583 Modulates Porcine Granulosa Cell Proliferation Through a miR-193a-5p/ACVR1-Associated Mechanism [PDF]
AnimalsOvarian follicular development is essential for reproductive performance in sows, with granulosa cells playing a central role in follicular growth and function.
Jingyang Dong +10 more
doaj +2 more sources
Heterotopic Ossification: Molecular Drivers, Subtype-Specific Mechanisms, and Translational Therapeutic Advances [PDF]
BiomoleculesHeterotopic ossification (HO), the pathological formation of mature bone in non-skeletal soft tissues (e.g., muscles, tendons), severely impairs patient mobility and quality of life.
Sihong Chen, Hui Lin
doaj +2 more sources
A closed-loop cell therapy engineered to autonomously secrete activin A inhibitor protects from fibrodysplasia ossificans progressiva [PDF]
iScienceSummary: Engineered cell therapies present an opportunity for endogenous, site-specific production of therapeutic agents. Fibrodysplasia ossificans progressiva (FOP) is a morbid condition in which patients develop extensive heterotopic bony lesions in ...
Pratik Koirala +9 more
doaj +2 more sources
npj Regenerative Medicine, 2022 Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease in which extraskeletal (heterotopic) bone forms within tissues such as skeletal muscles, often in response to injury.
Alexandra Stanley +5 more
doaj +1 more source
Biomolecules, 2023 Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by progressive disabling heterotopic ossification (HO) at extra-skeletal sites. Here, we developed adeno-associated virus (AAV)-based gene therapy that suppresses
Yeon-Suk Yang +6 more
doaj +1 more source