Results 31 to 40 of about 5,020 (198)

Inhibition of ACVR1 in Cancer-Associated Fibroblasts Suppresses Colorectal Cancer Cell Growth. [PDF]

Ann Surg Oncol
The version of record of this article, first published in Annals of Surgical Oncology (2025), is available online at Publisher’s website: https://doi.org/10.1245/s10434-025-17765-0.Background: Colorectal cancer (CRC) is the third most common malignancy ...
Kato S, Miyoshi N, Fujino S, Horie M, Yachida S, Takeda M, Sekido Y, Hata T, Hamabe A, Ogino T, Uemura M, Yamamoto H, Yasui M, Ohue M, Doki Y, Eguchi H.   +15 more
europepmc   +2 more sources

Variable signaling activity by FOP ACVR1 mutations [PDF]

Bone, 2018
Most patients with fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder of heterotopic ossification, have the same causative mutation in ACVR1, R206H. However, additional mutations within the ACVR1 BMP type I receptor have been identified in a small number of FOP cases, often in patients with disease of lesser or greater severity than ...
Julia, Haupt, Meiqi, Xu, Eileen M, Shore
openaire   +2 more sources

Intracellular metabolomics of control and ca-Acvr1(A11) mutant nasal process cells

, 2023
To probe for possible effects of elevated BMP signaling in CNCCs through constitutively activated ACVR1 (ca-ACVR1) at the metabolite level, we performed quantitative metabolomic profiling of control and ca-Acvr1(A11) mutant nasal process cells.THIS ...
Zhu, L (via Mendeley Data), Zhu, Lingxin
core   +1 more source

Pacritinib is a potent ACVR1 inhibitor with significant anemia benefit in patients with myelofibrosis [PDF]

, 2023
In patients with cytopenic myelofibrosis, treatment with the JAK2/IRAK1 inhibitor pacritinib was associated with anemia benefit in the phase 3 PERSIST-2 study.
Oh, Stephen T, et al.,, Kong, Tim
core   +1 more source

Fibrodysplasia ossificans progressiva: current concepts from bench to bedside

Disease Models & Mechanisms, 2020
Heterotopic ossification (HO) is a disorder characterised by the formation of ectopic bone in soft tissue. Acquired HO typically occurs in response to trauma and is relatively common, yet its aetiology remains poorly understood.
Arun-Kumar Kaliya-Perumal, Tom J. Carney, Philip W. Ingham   +2 more
doaj   +1 more source

Single-cell omics reveals the role of ACVR1 in odontoblastic differentiation [PDF]

口腔疾病防治
Objective To investigate the impact of activin receptor type-1 (ACVR1) on odontoblastic differentiation and dentin formation based on single-cell RNA sequencing. Methods A correlation analysis of ACVR1 with odontogenesis-related transcription factors was
SONG Shaoyi, LIU Cangwei, SHI CE, LIU Qilin, SUN Hongchen
doaj   +1 more source

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

eLife, 2020
Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC).
Senem Aykul, Richard A Corpina, Erich J Goebel, Camille J Cunanan, Alexandra Dimitriou, Hyon Jong Kim, Qian Zhang, Ashique Rafique, Raymond Leidich, Xin Wang, Joyce McClain, Johanna Jimenez, Kalyan C Nannuru, Nyanza J Rothman, John B Lees-Shepard, Erik Martinez-Hackert, Andrew J Murphy, Thomas B Thompson, Aris N Economides, Vincent Idone   +19 more
doaj   +1 more source

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice

The Journal of Clinical Investigation, 2022
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive and catastrophic heterotopic ossification (HO) of skeletal muscle and associated soft tissues.
John B. Lees-Shepard, Sean J. Stoessel, Julian T. Chandler, Keith Bouchard, Patricia Bento, Lorraine N. Apuzzo, Parvathi M. Devarakonda, Jeffrey W. Hunter, David J. Goldhamer   +8 more
doaj   +1 more source

Influence on proliferation and apoptosis of intestinal epithelial cells and expression of ACVR1 by Helicobacter pylori

European Journal of Inflammation, 2021
To discuss the influence on proliferation and apoptosis of human intestinal epithelial cells by Helicobacter pylori (Hp). CCK-8 method and flow cytometry to test the influence on proliferation and apoptosis of intestinal epithelial cells by Hp and cell ...
Yunfeng Lin, Min Chen, Shuyu Zhang, Zhichun Feng, Jingwen Wang   +4 more
doaj   +1 more source

Modeling the ACVR1R206H mutation in human skeletal muscle stem cells

eLife, 2021
Abnormalities in skeletal muscle repair can lead to poor function and complications such as scarring or heterotopic ossification (HO). Here, we use fibrodysplasia ossificans progressiva (FOP), a disease of progressive HO caused by ACVR1R206H (Activin ...
Emilie Barruet, Steven M Garcia, Jake Wu, Blanca M Morales, Stanley Tamaki, Tania Moody, Jason H Pomerantz, Edward C Hsiao   +7 more
doaj   +1 more source