Results 41 to 50 of about 6,796 (211)

Brown Fat Paucity Due to Impaired BMP Signaling Induces Compensatory Browning of White Fat [PDF]

, 2014
Summary Maintenance of body temperature is essential for survival of homeotherms. Brown adipose tissue (BAT) is a specialized fat tissue that is dedicated to thermoregulation1.
Cypess, Aaron M., Gussoni, Emanuela, Huang, Ping, Huang, Tian Lian, McDougall, Lindsay E., Mishina, Yuji, Schulz, Tim J., Townsend, Kristy L., Tseng, Yu-Hua, Xue, Ruidan   +9 more
core   +1 more source

Fibrodisplasia Osificante Progresiva: Reporte de Primer Caso Guatemalteco

Revista de la Facultad de Medicina, 2023
La Fibrodisplasia Osificante Progresiva (FOP) es una enfermedad rara, compleja, de herencia autosómica dominante, causada por una mutación heterocigota del gen ACVR1 en el cromosoma 2q24 (OMIM 135100), con una prevalencia de 1 en 2 millones en todo el ...
Marcela Elizabeth Orozco Orozco, Anna Yurrita Pocasangre, María Antonieta Sandoval Vargas, Julio Rafael Cabrera Valverde   +3 more
doaj   +1 more source

Approaches Toward Improving the Prognosis of Pediatric Patients With Glioma: Pursuing Mutant Drug Targets With Emerging Small Molecules [PDF]

, 2014
Gliomas represent approximately 70% of all pediatric brain tumors and most of these are of astrocytic lineage, furthermore, malignant or high-grade astrocytoma account for approximately 20% of pediatric astrocytoma. Treatment options for pediatric glioma
Snape, Timothy J., Warr, Tracy
core   +1 more source

High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva

Disease Models & Mechanisms, 2016
The ACVR1 gene encodes a type I receptor of bone morphogenetic proteins (BMPs). Activating mutations in ACVR1 are responsible for fibrodysplasia ossificans progressiva (FOP), a rare disease characterized by congenital toe malformation and progressive ...
Serena Cappato, Laura Tonachini, Francesca Giacopelli, Mario Tirone, Luis J. V. Galietta, Martina Sormani, Anna Giovenzana, Antonello E. Spinelli, Barbara Canciani, Silvia Brunelli, Roberto Ravazzolo, Renata Bocciardi   +11 more
doaj   +1 more source

MicroRNA bta-miR-365-3p inhibits proliferation but promotes differentiation of primary bovine myoblasts by targeting the activin A receptor type I

Journal of Animal Science and Biotechnology, 2021
Background MicroRNAs act as post-transcriptional regulators that repress translation or degrade mRNA transcripts. Each microRNA has many mRNA targets and each mRNA may be targeted by several microRNAs.
Dan Hao, Xiaogang Wang, Xiao Wang, Bo Thomsen, Yu Yang, Xianyong Lan, Yongzhen Huang, Hong Chen   +7 more
doaj   +1 more source

The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens

Disease Models & Mechanisms, 2011
SUMMARY We previously found that lenses lacking the Acvr1 gene, which encodes a bone morphogenetic protein (BMP) receptor, had abnormal proliferation and cell death in epithelial and cortical fiber cells.
Luke A. Wiley, Ramya Rajagopal, Lisa K. Dattilo, David C. Beebe   +3 more
doaj   +1 more source

ACVR1 mutation and Fibrodysplasia Ossificans Progressiva in Chinese children [PDF]

Pediatric Rheumatology, 2011
Fibrodysplasia Ossificans Progressiva (FOP) is a rare autosomal dominant connective tissue disorder characterized by congenital great toes malformation and progressive heterotopic osteogenesis leading to progressive debilitating ankylosis of the body.
Ng Bobby KW, Liu KL, Chan KH, Hui Joannie, Ho Assunta CH, Lo Ivan FM, Lam STS   +6 more
openaire   +2 more sources

Cross-talk among AFAP1-AS1, ACVR1 and microRNA-384 regulates the stemness of pancreatic cancer cells and tumorigenicity in nude mice

Journal of Experimental & Clinical Cancer Research, 2019
Background Pancreatic cancer (PC) represents one of the most aggressive forms of cancer. The role of long non-coding RNAs (lncRNAs) has been highlighted in various malignancies including PC.
Xu-Bo Wu, Xia Feng, Qi-Meng Chang, Cheng-Wu Zhang, Zhi-Fei Wang, Jie Liu, Zhi-Qiu Hu, Jia-Zhe Liu, Wei-Ding Wu, Zi-Ping Zhang, Xi-Qiang Liu   +10 more
doaj   +1 more source

Myositis ossificans circumscripta of the buccinator muscle: first report of a rare complication of mandibular third molar extraction. [PDF]

, 2008
Myositis ossificans is a self-limiting ossifying process that most often develops following mechanical trauma to skeletal musculature. It chiefly affects the skeletal muscles of extremities of young athletically active adult males. Myositis ossificans is
Abramovitch, Kenneth, Bouquot, Jerry, Thurber, David, Vigneswaran, Nadarajah, Wiggins, Raymond L   +4 more
core   +1 more source

Twists in the fibrodysplasia ossificans progressiva story challenge and expand our understanding of BMP biology

The Journal of Clinical Investigation, 2022
Fibrodysplasia ossificans progressiva (FOP) is an ultrarare, debilitating disease in which heterotopic bone is formed in certain soft tissues. A gain-of-function variant in the cytoplasmic domain of the activin A receptor type I (ACVR1) exists in all ...
Michael T. Collins
doaj   +1 more source