Results 61 to 70 of about 6,796 (211)
Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling
Cell Proliferation, EarlyView.BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou +8 more
wiley +1 more source
Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma [PDF]
, 2017 Recent exciting work partly through The Cancer Genome Atlas has implicated epigenetic mechanisms including histone modifications in the development of both pediatric and adult high-grade glioma (HGG).
Kurian, Kathreena M +4 more
core +1 more source
Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1339-1351, May 2026.Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang +5 more
wiley +1 more source
Clinical, radiological, and molecular diagnosis of progressive fibrodysplasia ossificans
Boletín Médico del Hospital Infantil de México, 2021 Background: Progressive fibrodysplasia ossificans is a rare genetic disease with heterozygous mutations (autosomal dominant inheritance) in the ACVR1 gene, which causes progressive heterotopic ossification in muscles, tendons, and ligaments, usually ...
Vianey Ordóñez-Labastida +6 more
doaj +1 more source
Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]
, 2017 Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita +5 more
core +3 more sources
Brain and Behavior, Volume 16, Issue 4, April 2026.Can invasive suckermouth catfish, Hypostomus plecostomus, be used as fishmeal? A potential solution to eradicate it from the Buriganga River, Bangladesh ABSTRACT Background and objective: Sarcoidosis, characterized by granulomatous inflammation across multiple systems, has an unclear connection with ischemic stroke and shared molecular pathways.
Zihong Bai +7 more
wiley +1 more source
Virus Titration And Test Expression Of Acvr1
, 2018 Test expression of ACVR1 using different virus levels to infect the insect cells. Purification of tests.
Adamson, Roslin +3 more
openaire +1 more source
Intersection of brain development and paediatric diffuse midline gliomas: potential role of microenvironment in tumour growth [PDF]
, 2018 Diffuse intrinsic pontine glioma (DIPG) is a devastating and incurable paediatric brain tumour with a median overall survival of 9 months. Until recently, DIPGs were treated similarly to adult gliomas, but due to the advancement in molecular and imaging ...
Fillmore, Helen, Loveson, Katie
core +1 more source
Advanced Science, Volume 13, Issue 13, 3 March 2026.Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang +16 more
wiley +1 more source
Pediatric Rheumatology Online Journal, 2023 Fibrodysplasia ossificans progressive (FOP) is an ultra-rare genetic disorder that is caused by a mutation in the ACVR1 gene and provokes severe heterotopic ossification.
Irina P. Nikishina +7 more
doaj +1 more source