Results 61 to 70 of about 4,120 (178)
Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
Scientific Reports, 2021 The objective of the present study was to discover the genetic variants, functional candidate genes, biological processes and molecular functions underlying the negative genetic correlation observed between body weight (BW) and egg number (EN) traits in ...
Eirini Tarsani +4 more
doaj +1 more source
Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.ABSTRACT Liquid biopsy has emerged as an important diagnostic paradigm impacting care across multiple cancer indications. This is also an area of great interest in pediatric solid tumours, including those affecting the central nervous system (CNS). Of special concern are pediatric high‐grade gliomas (pHGGs) due to the associated diagnostic complexities,
Samia Jahouri +6 more
wiley +1 more source
Cancer, Volume 132, Issue 10, 15 May 2026.Momelotinib demonstrated robust real‐world activity after ruxolitinib failure, with clinically meaningful improvements in spleen (≥50% spleen length reduction, 30.0%), symptoms (≥50% total symptoms score reduction, 39.2%), and anemia (major response, 35.7%) at 6 months.
Francesca Palandri +41 more
wiley +1 more source
Purification Of Acvr1 For Co_Crystallisation With Ldn_193189 And Other Compounds
, 2018 Purification protocol for ACVR1 and crystallisation with different compounds.
Adamson, Roslin +3 more
openaire +2 more sources
MicroRNA-384 inhibits the progression of breast cancer by targeting ACVR1
Oncology Reports, 2018 Breast cancer is the leading cause of cancer-related deaths in females worldwide. Triple-negative breast cancer (TNBC) accounts for 15% of all breast cancer cases and has a poorer prognosis than other subtypes. Moreover, the treatment for breast cancer, especially for TNBC, remains unsatisfactory.
Wang, Yongxia +2 more
openaire +3 more sources
BiomedicinesFibrodysplasia ossificans progressiva (FOP) is a debilitating genetic disorder characterized by recurrent episodes of heterotopic ossification (HO) formation in muscles, tendons, and ligaments.
Loreilys Mejias Rivera +2 more
doaj +1 more source
Clinical Aspects and Current Therapeutic Approaches for FOP
Biomedicines, 2020 Fibrodysplasia ossificans progressiva (FOP) is an extremely rare heritable disorder of connective tissues characterized by progressive heterotopic ossification in various skeletal sites.
Hiroshi Kitoh
doaj +1 more source
Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1339-1351, May 2026.Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang +5 more
wiley +1 more source
Purification of ACVR1 for fine screening with M4K compounds_Nov_2018
, 2018 The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada, Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no.
Adamson, Roslin +3 more
openaire +2 more sources
Brain and Behavior, Volume 16, Issue 4, April 2026.Can invasive suckermouth catfish, Hypostomus plecostomus, be used as fishmeal? A potential solution to eradicate it from the Buriganga River, Bangladesh ABSTRACT Background and objective Sarcoidosis, characterized by granulomatous inflammation across multiple systems, has an unclear connection with ischemic stroke and shared molecular pathways.
Zihong Bai +7 more
wiley +1 more source