Results 71 to 80 of about 6,796 (211)

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism [PDF]

, 2019
A major target of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation.
Albrechtsen, N., Araki, E., Batista, T., Cai, W., Cederquist, C., Damasio, M., Enerback, S., Gupta, M., Homan, E., Kahn, C., Mann, M., Ramirez, A., Sakaguchi, M., Singh, S., Steger, M., Wang, C.   +15 more
core   +2 more sources

Population Pharmacokinetics and Exposure–Response Analyses of Momelotinib, Its Active Metabolite (M21), and Total Active Moiety in Myelofibrosis

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 629-640, March 2026.
Momelotinib, a Janus kinase (JAK) 1/JAK2/activin A receptor type 1 inhibitor, is approved for the treatment of myelofibrosis with anemia. These analyses characterized the population pharmacokinetics of momelotinib and its active metabolite M21 following administration of the commercial tablet formulation in patients with myelofibrosis from phase II/III
Benjamin Rich, Meenakshi Srinivasan, Yu Liu Ho, Sandra A.G. Visser, Geraldine Ferron‐Brady, Georgios Vlasakakis   +5 more
wiley   +1 more source

BMP‐ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B‐Cell Lymphoma

Advanced Science
EZH2 is the catalytic subunit of the histone methyltransferase Polycomb Repressive Complex 2 (PRC2), and its somatic activating mutations drive lymphoma, particularly the germinal center B‐cell type.
Dongdong Liu, Zhen Li, Dongxia Tan, Yang An, Liping Chu, Tiancheng Chen, Weijia Li, Ailin Zhou, Ruijie Xiang, Liye Zhang, Yuxiu Qu, Wei Qi   +11 more
doaj   +1 more source

KoVariome: Korean National Standard Reference Variome database of whole genomes with comprehensive SNV, indel, CNV, and SV analyses [PDF]

, 2018
High-coverage whole-genome sequencing data of a single ethnicity can provide a useful catalogue of population-specific genetic variations, and provides a critical resource that can be used to more accurately identify pathogenic genetic variants.
A McKenna, A Scally, A Telenti, AA Alshatwi, B Charlesworth, C Dong, C Genomes Project, C Loveday, D Hong, D Lakich, D Pinto, D Welter, DE Reich, DG MacArthur, DI Boomsma, EM Shore, FS Collins, GH Perry, H Li, H Stefansson, HP-AS Consortium, J Huddleston, J Jakobsson, J Wang, JI Kim, JR MacDonald, K Chen, K Ye, L Feuk, LP Wong, LT Chen, M Lek, M Nagasaki, MC Hunt, MJ Bamshad, MJ Landrum, ML Bondeson, P Cingolani, P Kraft, PH Sudmant, PH Sudmant, R Ihaka, R Redon, RE Mills, S Besenbacher, S Lee, S Malik, S Purcell, S Tunaru, SA McCarroll, SH Kwak, SM Ahn, ST Sherry, T Mimori, TL Yang, V Boeva, W Zhang, X Wang, YS Cho, YS Ju   +59 more
core   +2 more sources

Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia

Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.
This study shows that the blood‐derived molecule, Fibrinogen, has a differential effect on human Oligodendroglial (OL) cells. Fibrinogen, when added in vitro, leads to aberrant differentiation of OL‐precursors towards an astrocytic fate. On the other hand, when added into the culture of mature OLs, fibrinogen increases myelination capacity.
Gabriela J. Blaszczyk, Chao Weng, Abdulshakour Mohammadnia, Qiao‐Ling Cui, Arianna Giurleo, Adam M. R. Groh, Chloe Plouffe, Julien Sirois, Valerio E. C. Piscopo, Moein Yaqubi, Asad Taqvi, Erin Cassidy, Liam Callahan Martin, Jeffery A. Hall, Roy W. R. Dudley, Myriam Srour, Stephanie E. J. Zandee, Wendy Klement, Sandra Larouche, Alexandre Prat, Thomas M. Durcan, Jo Anne Stratton, Jack P. Antel, G. R. Wayne Moore   +23 more
wiley   +1 more source

Fibrodysplasia ossificans progressiva with minor unilateral hallux anomaly in a sporadic case from Northern Tanzania with the common ACVR1c.617G A mutation

The Pan African Medical Journal, 2015
Fibrodysplasia ossificans progressiva is a rare autosomal dominantly inherited disorder of connective tissue caused by mutations in the gene encoding for ACVR1/ALK2, a bone morphogenetic protein type I receptor.
Mohammed Saleh, Joost Commandeur, Renata Bocciardi, Grace Kinabo, Ben Hamel   +4 more
doaj   +1 more source

Endogenous bioelectric currents promote differentiation of the mammalian lens [PDF]

, 2018
Acknowledgements We are grateful to Kevin S. Mackenzie in our imaging core facility. This work was supported by the University of Aberdeen (at which the majority of the experimental work was conducted).
Andley, Banno, Barrett, Bassnett, Bhat, Bhuyan, Blackiston, Bortner, Call, Cao, Chen, Chen, Chen, Eperon, Franco, Gwon, Gwon, Ibaraki, Kalous, Kolosova, Korlimbinis, Lampi, Lampi, Lee, Liu, Lois, Lovicu, Mathias, McCaig, Park, Patterson, Piatigorsky, Rajagopal, Robinson, Robinson, Sanderson, Sellitto, Shestopalov, Shestopalov, Sundelacruz, Sundelacruz, Sundelacruz, Thylefors, Ueda, Vaghefi, Wang, Wang, Wang, White, Wind, Wormstone, Yang, Zhao   +52 more
core   +1 more source

A Transcriptomic Analysis of Cancer‐Stromal Interactome in Lung Cancer Xenograft Models

Cancer Science, Volume 117, Issue 3, Page 841-851, March 2026.
We conducted a comprehensive analysis of the lung cancer interactome to identify key ligand–receptor pairs involved in the aggressiveness of lung adenocarcinoma. Tumor necrosis factor superfamily member 12 and its receptor tumor necrosis factor receptor superfamily member 12A signaling axis may be potential candidates for therapeutic intervention for ...
Yuriko Takayama‐Isagawa, Daisuke Komura, Takayuki Isagawa, Yusuke Amano, Atsushi Kihara, Tamaki Miura, Taichiro Yoshimoto, Hiroyoshi Tsubochi, Kazutaka Fujita, Koichi Hagiwara, Makoto Maemondo, Tetsuo Ushiku, Shumpei Ishikawa, Noriyoshi Fukushima, Kentaro Inamura, Daisuke Matsubara, Toshiro Niki   +16 more
wiley   +1 more source

Acvr1 And Tgfbr1 Purification, And Composite Screen Design

, 2018
Purification of ACVR1 as well as TGFBR1, and design of a super screen for ...
Adamson, Roslin, Brennan, Paul, Mateucci, Mizio, Bullock, Alex   +3 more
openaire   +1 more source

Survival and quality‐of‐life implications of cytopenia trajectories in ruxolitinib‐treated myelofibrosis

Cancer, Volume 132, Issue 4, 15 February 2026.
Abstract Background Cytopenia is a common complication in patients with myelofibrosis and may worsen during treatment with ruxolitinib. Methods The RUX‐MF multicenter study evaluated 879 patients treated with ruxolitinib for at least 6 months, categorizing them into four groups based on the evolution of cytopenia: never cytopenic, treatment‐emergent ...
Francesca Palandri, Giovanni Caocci, Elisabetta Abruzzese, Mario Tiribelli, Erika Morsia, Mirko Farina, Giulia Benevolo, Eloise Beggiato, Bruno Martino, Novella Pugliese, Alessia Tieghi, Monica Crugnola, Gianni Binotto, Francesco Cavazzini, Alessandra Iurlo, Alessandro Isidori, Alessandra Dedola, Emilia Scalzulli, Andrea Duminuco, Daniele Cattaneo, Roberto M. Lemoli, Costanza Bosi, Daniela Cilloni, Monica Bocchia, Fabrizio Pane, Chiara Sartor, Florian H. Heidel, Massimo Breccia, Filippo Branzanti, Giuseppe A. Palumbo, Massimiliano Bonifacio, Elena M. Elli   +31 more
wiley   +1 more source