Results 1 to 10 of about 14,689 (206)

Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors [PDF]

iScience, 2022
Summary: The 30+ unique ligands of the TGFβ family signal by forming complexes using different combinations of type I and type II receptors. Therapeutically, the extracellular domain of a single receptor fused to an Fc molecule can effectively neutralize
Erich J. Goebel, Chandramohan Kattamuri, Gregory R. Gipson, Lavanya Krishnan, Moises Chavez, Magdalena Czepnik, Michelle C. Maguire, Rosa Grenha, Maria Håkansson, Derek T. Logan, Asya V. Grinberg, Dianne Sako, Roselyne Castonguay, Ravindra Kumar, Thomas B. Thompson   +14 more
doaj   +3 more sources

BMPR2 Dosage Gates BMP9/10 Signaling Output in Pulmonary Artery Endothelium [PDF]

Cells
Pulmonary arterial hypertension (PAH) is characterized by dysfunction and remodeling of the pulmonary artery endothelium and smooth muscle. In heritable PAH, heterozygous loss-of-function mutations in the type II Bone Morphogenetic Protein (BMP) receptor
Kit-Yee Chu, Vijayalakshmi Thamilselvan, Amberly N. Crawford, Paul B. Yu, Erik Martinez-Hackert   +4 more
doaj   +2 more sources

Loss of ALK4 promotes cancer progression through regulating TGF-β receptor N-glycosylation [PDF]

Nature Communications
The transforming growth factor-β (TGF-β) pathway typically inhibits tumorigenesis but can promote metastasis during cancer progression. Activin receptor-like kinase 4 (ALK4), a type I TGF-β family receptor, is frequently downregulated or mutated in ...
Manqi Zhang, Jian Chen, Mary C. Leupold, Jennifer Guo, Xiangfeng Shen, Carl A. Shirley, Christen A. Khella, Rushabh N. Mehta, Edward T. O’Brien, Michael L. Gatza, Gerard C. Blobe   +10 more
doaj   +2 more sources

Truncated Activin Type I Receptor Alk4 Isoforms Are Dominant Negative Receptors Inhibiting Activin Signaling [PDF]

Molecular Endocrinology, 2000
Activin, a member of the transforming growth factor beta (TGFbeta) superfamily of cytokines, inhibits cell proliferation in a variety of cell types. The functions of activin are mediated by type I and type II serine/threonine kinase receptors. The main type I receptor mediating activin signaling in human cells is ActRIB, also called Alk4.
Y, Zhou, H, Sun, D C, Danila, S R, Johnson, D P, Sigai, X, Zhang, A, Klibanski   +6 more
openaire   +3 more sources

Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways

BMC Biology, 2022
Background Activins and bone morphogenetic proteins (BMPs) play critical, sometimes opposing roles, in multiple physiological and pathological processes and diseases.
Szabina Szófia Szilágyi, Ayelet R. Amsalem-Zafran, Keren E. Shapira, Marcelo Ehrlich, Yoav I. Henis   +4 more
doaj   +1 more source

The orphan ligand, activin C, signals through activin receptor-like kinase 7

eLife, 2022
Activin ligands are formed from two disulfide-linked inhibin β (Inhβ) subunit chains. They exist as homodimeric proteins, as in the case of activin A (ActA; InhβA/InhβA) or activin C (ActC; InhβC/InhβC), or as heterodimers, as with activin AC (ActAC ...
Erich J Goebel, Luisina Ongaro, Emily C Kappes, Kylie Vestal, Elitza Belcheva, Roselyne Castonguay, Ravindra Kumar, Daniel J Bernard, Thomas B Thompson   +8 more
doaj   +1 more source

ACVR1 (activin A receptor, type I) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on ACVR1 (activin A receptor, type I), with data on DNA, on the protein encoded, and where the gene is implicated.
Rainho, CA, Rogatto, SR
openaire   +2 more sources

Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes).

PLoS ONE, 2023
Activin and Bone Morphogenetic Protein (BMP) signaling plays crucial roles in vertebrate organ formation, including osteo- and angiogenesis, and tissue homeostasis, such as neuronal maintenance.
Michael Trumpp, Wen Hui Tan, Wiktor Burdzinski, Yara Basler, Jerome Jatzlau, Petra Knaus, Christoph Winkler   +6 more
doaj   +1 more source

Myostatin/Activin-A Signaling in the Vessel Wall and Vascular Calcification

Cells, 2021
A current hypothesis is that transforming growth factor-β signaling ligands, such as activin-A and myostatin, play a role in vascular damage in atherosclerosis and chronic kidney disease (CKD).
Pasquale Esposito, Daniela Verzola, Daniela Picciotto, Leda Cipriani, Francesca Viazzi, Giacomo Garibotto   +5 more
doaj   +1 more source

Utilizing BMP-2 muteins for treatment of multiple myeloma. [PDF]

PLoS ONE, 2017
Multiple myeloma (MM) represents a haematological cancer characterized by the pathological hyper proliferation of antibody-producing B-lymphocytes. Patients typically suffer from kidney malfunction and skeletal disorders.
Axel Seher, Charlotte Lagler, Thorsten Stühmer, Urs Dietmar Achim Müller-Richter, Alexander Christian Kübler, Walter Sebald, Thomas Dieter Müller, Joachim Nickel   +7 more
doaj   +1 more source