Results 31 to 40 of about 14,689 (206)
Regulation of activin type I receptor function by phosphorylation of residues outside the GS domain [PDF]
FEBS Letters, 1997 Activin signals through a heteromeric complex of receptor serine kinases by inducing type II receptor‐mediated phosphorylation, and consequent activation, of the type I receptor. Type I receptor phosphorylation occurs at a glycine‐ and serine‐rich site in the juxtamembrane domain; phosphorylation at that site correlates with signaling. Investigation of
Willis, Susan A, Mathews, Lawrence S
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Accelerated reendothelialization, increased neovascularization and erythrocyte extravasation after arterial injury in BAMBI-/- mice. [PDF]
PLoS ONE, 2013 Intimal injury rapidly activates TGFβ and enhances vascular repair by the growth of endothelial (EC) and vascular smooth muscle cells (VSMC). The response to the TGFβ family of growth factors can be modified by BAMBI (BMP, Activin, Membrane Bound ...
Nicolas Guillot +4 more
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The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse [PDF]
Genes & Development, 1998 ActRIB is a type I transmembrane serine/threonine kinase receptor that has been shown to form heteromeric complexes with the type II activin receptors to mediate activin signal. To investigate the function of ActRIB in mammalian development, we generated ActRIB-deficient ES cell lines and mice by gene targeting. Analysis of the ActRIB-/- embryos showed
Z, Gu +7 more
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The Journal of Reproduction and Development, 2020 Previous studies in the 1960s and 1970s have reported that both gonadotropin-releasing hormone (GnRH) and estradiol-activated nuclear estrogen receptors regulate gonadotropin secretion in women.
Hiroya KADOKAWA
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Phosphorylation regulation of the interaction between Smad7 and activin type I receptor
FEBS Letters, 2002 Signal transduction of activin, one of the members in the transforming growth factor‐β superfamily, is initiated by ligand binding with two distinct membrane receptors (type II and type I) followed by activation of Smad2 or Smad3. We report here that activin‐induced signaling is negatively regulated by another Smad molecule, Smad7.
Liu, Xubao +3 more
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Reproductive Biology and Endocrinology, 2005 Background Activins stimulate the synthesis of follicle stimulating hormone (FSH) in pituitary gonadotropes, at least in part, by inducing transcription of its beta subunit (Fshb).
Miller William L +3 more
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Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells. [PDF]
Reproductive Biology and Endocrinology, 2003 Activin is known to play an important regulatory role in reproduction, including pregnancy. To further examine the role and signaling mechanism of activin in regulating placental function, the steady-state level of activin type I receptor (ActRI) mRNA in immortalized extravillous trophoblasts (IEVT) cells was measured using competitive PCR (cPCR).
Chen, Victor T +2 more
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Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor. [PDF]
Proceedings of the National Academy of Sciences, 1993 Activin type II receptors are transmembrane protein-serine/threonine kinases. By using a reverse-transcription PCR assay to screen for protein kinase sequences, we isolated a cDNA clone, activin X1 receptor, from rat brain that encodes a 55-kDa transmembrane protein-serine kinase which is structurally related to other receptors in this kinase subfamily.
K, Tsuchida, L S, Mathews, W W, Vale
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Growth Differentiation Factor-9 Signaling Is Mediated by the Type I Receptor, Activin Receptor-Like Kinase 5 [PDF]
Molecular Endocrinology, 2004 Growth differentiation factor-9 (GDF-9) is an oocyte-derived growth factor and a member of the TGF-beta superfamily that includes TGF-beta, activin, and bone morphogenetic proteins (BMPs). GDF-9 is indispensable for the development of ovarian follicles from the primary stage, and treatment with GDF-9 enhances the progression of early follicles into ...
Mazerbourg, S. +7 more
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Soluble activin receptor type IIB increases forward pulling tension in the mdx mouse [PDF]
Muscle & Nerve, 2011 AbstractIntroduction: In this study we investigated the action of RAP‐031, a soluble activin receptor type IIB (ActRIIB) comprised of a form of the ActRIIB extracellular domain linked to a murine Fc, and the NF‐κB inhibitor, ursodeoxycholic acid (UDCA), on the whole body strength of mdx mice.
C, George Carlson +7 more
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