Results 1 to 10 of about 17,987 (225)

Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes). [PDF]

PLoS ONE, 2023
Activin and Bone Morphogenetic Protein (BMP) signaling plays crucial roles in vertebrate organ formation, including osteo- and angiogenesis, and tissue homeostasis, such as neuronal maintenance.
Michael Trumpp, Wen Hui Tan, Wiktor Burdzinski, Yara Basler, Jerome Jatzlau, Petra Knaus, Christoph Winkler   +6 more
doaj   +2 more sources

Localization of activin and activin receptors in rat spinal motoneurons

Journal of Biomedical Science, 1996
The purpose of this experiment was to determine whether rat spinal motoneurons (a) produce activin protein and (b) transcribe mRNAs coding for the betaA-subunit of activin and activin receptors II and IIB. The production of activin was determined by immunocytochemistry.
Shao-Yao Ying, Ying Shao-Yao
exaly   +3 more sources

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors

Biomolecules, 2020
Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway.
Oddrun Elise Olsen, Hanne Hella, Samah Elsaadi, Carsten Jacobi, Erik Martinez-Hackert, Toril Holien   +5 more
doaj   +3 more sources

Loss of ALK4 promotes cancer progression through regulating TGF-β receptor N-glycosylation [PDF]

Nature Communications
The transforming growth factor-β (TGF-β) pathway typically inhibits tumorigenesis but can promote metastasis during cancer progression. Activin receptor-like kinase 4 (ALK4), a type I TGF-β family receptor, is frequently downregulated or mutated in ...
Manqi Zhang, Jian Chen, Mary C. Leupold, Jennifer Guo, Xiangfeng Shen, Carl A. Shirley, Christen A. Khella, Rushabh N. Mehta, Edward T. O’Brien, Michael L. Gatza, Gerard C. Blobe   +10 more
doaj   +2 more sources

Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways

BMC Biology, 2022
Background Activins and bone morphogenetic proteins (BMPs) play critical, sometimes opposing roles, in multiple physiological and pathological processes and diseases.
Szabina Szófia Szilágyi, Ayelet R. Amsalem-Zafran, Keren E. Shapira, Marcelo Ehrlich, Yoav I. Henis   +4 more
doaj   +1 more source

Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease

Neurobiology of Disease, 2023
Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD).
Wissam B. Nassrallah, Daniel Ramandi, Judy Cheng, Jean Oh, James Mackay, Marja D. Sepers, David Lau, Hilmar Bading, Lynn A. Raymond   +8 more
doaj   +1 more source

Activin a suppresses peripheral CD8+ T lymphocyte activity in acute-phase Kawasaki disease

BMC Immunology, 2021
Background Kawasaki disease is an autoimmune disease characterized by systemic vasculitis of unknown aetiology and most commonly occurs in children under 5 years old.
Qian Wu, Ruohang Weng, Yongbin Xu, Linlin Wang, Yanyan Huang, Jun Yang   +5 more
doaj   +1 more source

Utilizing BMP-2 muteins for treatment of multiple myeloma. [PDF]

PLoS ONE, 2017
Multiple myeloma (MM) represents a haematological cancer characterized by the pathological hyper proliferation of antibody-producing B-lymphocytes. Patients typically suffer from kidney malfunction and skeletal disorders.
Axel Seher, Charlotte Lagler, Thorsten Stühmer, Urs Dietmar Achim Müller-Richter, Alexander Christian Kübler, Walter Sebald, Thomas Dieter Müller, Joachim Nickel   +7 more
doaj   +1 more source

R-Smad competition controls activin receptor output in Drosophila. [PDF]

PLoS ONE, 2012
Animals use TGF-β superfamily signal transduction pathways during development and tissue maintenance. The superfamily has traditionally been divided into TGF-β/Activin and BMP branches based on relationships between ligands, receptors, and R-Smads ...
Aidan J Peterson, Philip A Jensen, MaryJane Shimell, Ray Stefancsik, Ranjula Wijayatonge, Rachel Herder, Laurel A Raftery, Michael B O'Connor   +7 more
doaj   +1 more source

Different Immunoregulation Roles of Activin A Compared With TGF-β

Frontiers in Immunology, 2022
Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also
Fanglin Li, Fanglin Li, Yiru Long, Yiru Long, Xiaolu Yu, Xiaolu Yu, Yongliang Tong, Yongliang Tong, Likun Gong, Likun Gong, Likun Gong   +10 more
doaj   +1 more source