Results 31 to 40 of about 17,987 (225)

Mesenchymal Stem Cell-Derived Exosomes Protect Muscle Loss by miR-145-5p Activity Targeting Activin A Receptors

Cells, 2021
Skeletal muscle mass is decreased under a wide range of pathologic conditions. In particular, chemotherapy is well known for inducing muscle loss and atrophy.
Kyung-Ah Cho, Da-Won Choi, Yu-Hee Kim, Jungwoo Kim, Kyung-Ha Ryu, So-Youn Woo   +5 more
doaj   +1 more source

TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass

Frontiers in Physiology, 2020
Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting propeptides and antibodies, or follistatin can increase skeletal muscle mass in healthy mice and ameliorate wasting in models ...
Adam Hagg, Adam Hagg, Adam Hagg, Swati Kharoud, Swati Kharoud, Georgia Goodchild, Craig A. Goodman, Craig A. Goodman, Justin L. Chen, Justin L. Chen, Rachel E. Thomson, Rachel E. Thomson, Hongwei Qian, Hongwei Qian, Paul Gregorevic, Paul Gregorevic, Paul Gregorevic, Paul Gregorevic, Craig A. Harrison, Craig A. Harrison, Kelly L. Walton, Kelly L. Walton   +21 more
doaj   +1 more source

Identification of a Binding Site on the Type II Activin Receptor for Activin and Inhibin [PDF]

Journal of Biological Chemistry, 2000
Type II activin receptors (ActRII and ActRIIB) are single-transmembrane domain serine/threonine kinase receptors that bind activin to initiate the signaling and cellular responses triggered by this hormone. Inhibin also binds type II activin receptors and antagonizes many activin effects.
P C, Gray, J, Greenwald, A L, Blount, K S, Kunitake, C J, Donaldson, S, Choe, W, Vale   +6 more
openaire   +2 more sources

Maximal expression of Foxl2 in pituitary gonadotropes requires ovarian hormones. [PDF]

PLoS ONE, 2015
Gonadotropin-releasing hormone (GnRH) and activin regulate synthesis of FSH and ultimately fertility. Recent in vivo studies cast SMAD4 and FOXL2 as master transcriptional mediators of activin signaling that act together and independently of GnRH to ...
Maria K Herndon, John H Nilson
doaj   +1 more source

15-deoxy-Δ12,14-prostaglandin J2 Down-Regulates Activin-Induced Activin Receptor, Smad, and Cytokines Expression via Suppression of NF-κB and MAPK Signaling in HepG2 Cells

PPAR Research, 2013
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) and activin are implicated in the control of apoptosis, cell proliferation, and inflammation in cells. We examined both the mechanism by which 15d-PGJ2 regulates the transcription of activin-induced activin ...
Seung-Won Park, Chunghee Cho, Byung-Nam Cho, Youngchul Kim, Tae Won Goo, Young Il Kim   +5 more
doaj   +1 more source

Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.

PLoS ONE, 2015
The use of human pluripotent cell progeny for cardiac disease modeling, drug testing and therapeutics requires the ability to efficiently induce pluripotent cells into the cardiomyogenic lineage.
Min-Su Kim, Audrey Horst, Steven Blinka, Karl Stamm, Donna Mahnke, James Schuman, Rebekah Gundry, Aoy Tomita-Mitchell, John Lough   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Stepwise release of Activin-A from its inhibitory prodomain is modulated by cysteines and requires furin coexpression to promote melanoma growth

Communications Biology
The Activin-A precursor dimer can be cleaved by furin, but how this proteolytic maturation is regulated in vivo and how it facilitates access to signaling receptors is unclear.
Katarina Pinjusic, Manon Bulliard, Benjamin Rothé, Saeid Ansaryan, Yeng-Cheng Liu, Pierpaolo Ginefra, Céline Schmuziger, Hatice Altug, Daniel B. Constam   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Identification of a Drosophila activin receptor. [PDF]

Proceedings of the National Academy of Sciences, 1993
Activins are cytokines of the transforming growth factor beta superfamily that control various events during vertebrate embryo development and cell differentiation in the adult, and act through transmembrane receptors that contain a cytoplasmic protein-serine/threonine kinase domain.
S R, Childs, J L, Wrana, K, Arora, L, Attisano, M B, O'Connor, J, Massagué   +5 more
openaire   +2 more sources