Results 11 to 20 of about 14,689 (206)

R-Smad competition controls activin receptor output in Drosophila. [PDF]

PLoS ONE, 2012
Animals use TGF-β superfamily signal transduction pathways during development and tissue maintenance. The superfamily has traditionally been divided into TGF-β/Activin and BMP branches based on relationships between ligands, receptors, and R-Smads ...
Aidan J Peterson, Philip A Jensen, MaryJane Shimell, Ray Stefancsik, Ranjula Wijayatonge, Rachel Herder, Laurel A Raftery, Michael B O'Connor   +7 more
doaj   +1 more source

Regulation of Nodal signaling propagation by receptor interactions and positive feedback

eLife, 2022
During vertebrate embryogenesis, the germ layers are patterned by secreted Nodal signals. In the classical model, Nodals elicit signaling by binding to a complex comprising Type I/II Activin receptors (Acvr) and the co-receptor Tdgf1.
Hannes Preiß, Anna C Kögler, David Mörsdorf, Daniel Čapek, Gary H Soh, Katherine W Rogers, Hernán Morales-Navarrete, María Almuedo-Castillo, Patrick Müller   +8 more
doaj   +1 more source

Activin A promotes neuronal differentiation of cerebrocortical neural progenitor cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Activin A is a protein that participates principally in reproductive functions. In the adult brain, Activin is neuroprotective, but its role in brain development is still elusive.
Griselda Rodríguez-Martínez, Anayansi Molina-Hernández, Iván Velasco   +2 more
doaj   +1 more source

Identification of a Functional Binding Site for Activin on the Type I Receptor ALK4 [PDF]

Journal of Biological Chemistry, 2003
Activins, like other members of the transforming growth factor-beta (TGF-beta) superfamily, initiate signaling by assembling a complex of two types of transmembrane serine/threonine receptor kinases classified as type II (ActRII or ActRIIB) and type I (ALK4).
Craig A, Harrison, Peter C, Gray, Steven C, Koerber, Wolfgang, Fischer, Wylie, Vale   +4 more
openaire   +2 more sources

Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity

Biomolecules, 2023
Although structurally similar to type II counterparts, type I or activin receptor-like kinases (ALKs) are set apart by a metastable helix–loop–helix (HLH) element preceding the protein kinase domain that, according to a longstanding paradigm, serves ...
Jay C. Groppe, Guorong Lu, Mary R. Tandang-Silvas, Anupama Pathi, Shruti Konda, Jingfeng Wu, Viet Q. Le, Andria L. Culbert, Eileen M. Shore, Kristi A. Wharton, Frederick S. Kaplan   +10 more
doaj   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Endoglin-mediated suppression of prostate cancer invasion is regulated by activin and bone morphogenetic protein type II receptors. [PDF]

PLoS ONE, 2013
Mortality from prostate cancer (PCa) is due to the formation of metastatic disease. Understanding how that process is regulated is therefore critical. We previously demonstrated that endoglin, a type III transforming growth factor β (TGFβ) superfamily ...
Michael J Breen, Diarmuid M Moran, Wenzhe Liu, Xiaoke Huang, Calvin P H Vary, Raymond C Bergan   +5 more
doaj   +1 more source

Estradiol Upregulates the Expression of the TGF-β Receptors ALK5 and BMPR2 during the Gonadal Development of Schizothorax prenanti

Animals, 2021
TGF-β receptors play important roles in mediating TGF-β signals during gonadal development. To identify the functions of TGF-β receptors, including the type I receptor (activin receptor-like kinase 5, ALK5) and type II receptor (bone morphogenetic ...
Taiming Yan, Songpei Zhang, Yueping Cai, Zhijun Ma, Jiayang He, Qian Zhang, Faqiang Deng, Lijuan Ye, Hongjun Chen, Liang He, Jie Luo, Deying Yang, Zhi He   +12 more
doaj   +1 more source

FKBP12 functions as an adaptor of the Smad7–Smurf1 complex on activin type I receptor [PDF]

Journal of Molecular Endocrinology, 2006
The cytoplasmic immunophilin FKBP12, a 12 kDa FK506-binding protein, has been shown to act as an inhibitor for transforming growth factor-β (TGF-β) signaling. FKBP12 binds to the glycine- and serine-rich motif (GS motif) of the TGF-β type I receptor, and functions as a secure switch to prevent the leaky signal.
T, Yamaguchi, A, Kurisaki, N, Yamakawa, K, Minakuchi, H, Sugino   +4 more
openaire   +2 more sources

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source