Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily
Scientific Reports, 2021 Ligands of the transforming growth factor-β (TGF-β) superfamily are important targets for therapeutic intervention but present challenges because they signal combinatorially and exhibit overlapping activities in vivo.
Ravindra Kumar +14 more
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Immunocytochemical study of activin type IB receptor (XALK4) in Xenopus oocytes [PDF]
Development, Growth & Differentiation, 2003 Studies have shown that the activin type IB receptor is specific for activin/nodal signaling. Activin is produced by follicle cells in the ovary, and is incorporated into the oocytes. Antisera against three peptides were prepared, encompassing the extracellular, intracellular and serine/threonine kinase domains of the Xenopus type IB activin receptor ...
Akimasa, Fukui +3 more
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Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction. [PDF]
PLoS ONE, 2014 Members of the TGF-β superfamily play numerous roles in nervous system development and function. In Drosophila, retrograde BMP signaling at the neuromuscular junction (NMJ) is required presynaptically for proper synapse growth and neurotransmitter ...
Myung-Jun Kim, Michael B O'Connor
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Activin B can signal through both ALK4 and ALK7 in gonadotrope cells
Reproductive Biology and Endocrinology, 2006 Background Activins stimulate pituitary FSH synthesis via transcriptional regulation of the FSHbeta subunit gene (Fshb). Like other members of the TGFbeta superfamily, these ligands signal through complexes of type I and type II receptor serine/threonine
Lee Katharine B +2 more
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Activin and Inhibin Have Antagonistic Effects on Ligand-Dependent Heteromerization of the Type I and Type II Activin Receptors and Human Erythroid Differentiation [PDF]
Molecular and Cellular Biology, 1997 Activins and inhibins belong to the transforming growth factor beta (TGF-beta)-like superfamily and exert their effects on a broad range of cellular targets by modulating cell differentiation and proliferation. Members of this family interact with two structurally related classes of receptors (type I and type II), both containing a serine/threonine ...
J J, Lebrun, W W, Vale
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Activin signaling as an emerging target for therapeutic interventions
Cell Communication and Signaling, 2009 After the initial discovery of activins as important regulators of reproduction, novel and diverse roles have been unraveled for them. Activins are expressed in various tissues and have a broad range of activities including the regulation of gonadal ...
Ageta Hiroshi +6 more
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ACVR1B ( ALK4 , activin receptor type 1B) gene mutations in pancreatic carcinoma [PDF]
Proceedings of the National Academy of Sciences, 2001 DPC4 is known to mediate signals initiated by type β transforming growth factor (TGFβ) as well as by other TGFβ superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGFβ receptors have been negative to date. Here we describe the gene structure and novel
G H, Su +6 more
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Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance Myostatin and activin A are secreted signaling molecules that act to limit skeletal muscle growth. Here, we show that myostatin and activin A utilize four receptor components to signal directly to muscle fibers. These findings have implications for strategies to target this signaling pathway for clinical applications to ...
Se-Jin Lee +11 more
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Induction of transforming growth factor beta receptors following focal ischemia in the rat brain. [PDF]
PLoS ONE, 2014 Transforming growth factor-βs (TGF-βs) regulate cellular proliferation, differentiation, and survival. TGF-βs bind to type I (TGF-βRI) and II receptors (TGF-βRII), which are transmembrane kinase receptors, and an accessory type III receptor (TGF-βRIII ...
Gabriella Pál +2 more
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The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy. [PDF]
PLoS ONE, 2015 Myostatin, a muscle-specific transforming growth factor-β (TGF-β), negatively regulates skeletal muscle mass. The N-terminal prodomain of myostatin noncovalently binds to and suppresses the C-terminal mature domain (ligand) as an inactive circulating ...
Yutaka Ohsawa +11 more
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